Zobrazeno 1 - 10 of 660 pro vyhledávání: '"Tracy T, Batchelor"'
1
Akademický článek
Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants
Autor: Tikvah K. Hayes, Elisa Aquilanti, Nicole S. Persky, Xiaoping Yang, Erica E. Kim, Lisa Brenan, Amy B. Goodale, Douglas Alan, Ted Sharpe, Robert E. Shue, Lindsay Westlake, Lior Golomb, Brianna R. Silverman, Myshal D. Morris, Ty Running Fisher, Eden Beyene, Yvonne Y. Li, Andrew D. Cherniack, Federica Piccioni, J. Kevin Hicks, Andrew S. Chi, Daniel P. Cahill, Jorg Dietrich, Tracy T. Batchelor, David E. Root, Cory M. Johannessen, Matthew Meyerson
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The epidermal growth factor receptor, EGFR, is frequently activated in lung cancer and glioblastoma by genomic alterations including missense mutations. The different mutation spectra in these diseases are reflected in divergent responses to
Externí odkaz: https://doaj.org/article/0edde2f4b771457398e829246efe16d1
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3
Akademický článek
PIK3CA activating mutations are associated with more disseminated disease at presentation and earlier recurrence in glioblastoma
Autor: Shota Tanaka, Tracy T. Batchelor, A. John Iafrate, Dora Dias-Santagata, Darrell R. Borger, Leif W. Ellisen, Daniel Yang, David N. Louis, Daniel P. Cahill, Andrew S. Chi
Publikováno v: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-8 (2019)
Abstract Phosphatidylinositol 3-kinase signaling promotes cell growth and survival and is frequently activated in infiltrative gliomas. Activating mutations in PIK3CA gene are observed in 6–15% of glioblastomas, although their clinical significance
Externí odkaz: https://doaj.org/article/9b32b0e049694cab8a5749e82076e225
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5
Akademický článek
Pharmacodynamics of mutant-IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate
Autor: Ovidiu C. Andronesi, Isabel C. Arrillaga-Romany, K. Ina Ly, Wolfgang Bogner, Eva M. Ratai, Kara Reitz, A. John Iafrate, Jorg Dietrich, Elizabeth R. Gerstner, Andrew S. Chi, Bruce R. Rosen, Patrick Y. Wen, Daniel P. Cahill, Tracy T. Batchelor
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1) entered recently clinical trials for treatment of gliomas. Here, the authors apply a MRS imaging method for 2HG detection and assessement of the pharmacodynamic effects of the mutant IDH1 inhibit
Externí odkaz: https://doaj.org/article/b6420b3093174f1f828f783b189caae2
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7
Akademický článek
Early changes in glioblastoma metabolism measured by MR spectroscopic imaging during combination of anti-angiogenic cediranib and chemoradiation therapy are associated with survival
Autor: Ovidiu C. Andronesi, Morteza Esmaeili, Ronald J. H. Borra, Kyrre Emblem, Elizabeth R. Gerstner, Marco C. Pinho, Scott R. Plotkin, Andrew S. Chi, April F. Eichler, Jorg Dietrich, S. Percy Ivy, Patrick Y. Wen, Dan G. Duda, Rakesh Jain, Bruce R. Rosen, Gregory A. Sorensen, Tracy T. Batchelor
Publikováno v: npj Precision Oncology, Vol 1, Iss 1, Pp 1-9 (2017)
Metabolic imaging reveals anti-angiogenic (AA) therapy mechanisms in glioblastoma (GBM) GBM is the most common and aggressive type of malignant primary brain tumors (glioma). Patients with GBM have less than 5% survival at 5 years with the best exist
Externí odkaz: https://doaj.org/article/cff8891abc634b19b196fe665c1e1ac0
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8
Akademický článek
Clinical and radiographic response following targeting of BCAN-NTRK1 fusion in glioneuronal tumor
Autor: Christopher Alvarez-Breckenridge, Julie J. Miller, Naema Nayyar, Corey M. Gill, Andrew Kaneb, Megan D’Andrea, Long P. Le, Jesse Lee, Ju Cheng, Zongli Zheng, William E. Butler, Pratik Multani, Edna Chow Maneval, Sun Ha Paek, Brian D. Toyota, Dora Dias-Santagata, Sandro Santagata, Javier Romero, Alice T. Shaw, Anna F. Farago, Stephen Yip, Daniel P. Cahill, Tracy T. Batchelor, A. John Iafrate, Priscilla K. Brastianos
Publikováno v: npj Precision Oncology, Vol 1, Iss 1, Pp 1-5 (2017)
Abstract Glioneuronal tumors constitute a histologically diverse group of primary central nervous system neoplasms that are typically slow-growing and managed conservatively. Genetic alterations associated with glioneuronal tumors include BRAF mutati
Externí odkaz: https://doaj.org/article/566d486d09384fbf8d3ccde6c3b6828b
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