Výsledky vyhledávání - "Tracy Saxton"

Abstract 3332: LNG-451 is a potent, CNS-penetrant, wild-type EGFR sparing inhibitor of EGFR exon 20 insertion mutations

Autor: Brion W. Murray, Anjali Pandey, Bruce Roth, Tracy Saxton, Daniel J. Estes, Himanshu Agrawal, Santosh Vishwakarma, Gurulingappa Hallur, Ishtiyaque Ahmad, Ravi Trivedi, Helen Jenkins, Paul G. Pearson

Publikováno v: Cancer Research. 82:3332-3332

Exon 20 insertion mutations (Ex20ins) are the third most common type of EGFR oncogenic mutation in lung cancer patients. While several small molecules have been approved (mobocertinib) or are in clinical development (e.g. CLN-081, BDTX-189) none have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c98fba1e1834e4220525f131f5f82db
https://doi.org/10.1158/1538-7445.am2022-3332

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Abstract 3261: LNG-451, a potent inhibitor of EGFR exon 20 insertion mutations with high CNS exposure

Autor: Paul G. Pearson, Anjali Pandey, Bruce Roth, Tracy Saxton, Daniel J. Estes, Ravi Trivedi, Himanshu Agrawal, Gurulingappa Hallur, Ishtiyaque Ahmad, Helen Jenkins, Brion W. Murray

Publikováno v: Cancer Research. 82:3261-3261

Exon 20 insertion mutations (Ex20ins) are the 3rd most common type of EGFR oncogenic mutation in lung cancer patients and are often associated with brain metastases. While several small molecules have been approved (mobocertinib) or are in clinical d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4554fcb2ad8096165b4f8e4ac43d1dd8
https://doi.org/10.1158/1538-7445.am2022-3261

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