Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Tracy S. Mann"'
Autor:
Graham M. Donovan, Kimberley C. W. Wang, Danial Shamsuddin, Tracy S. Mann, Peter J. Henry, Alexander N. Larcombe, Peter B. Noble
Publikováno v:
Physiological Reports, Vol 8, Iss 11, Pp n/a-n/a (2020)
Abstract Airway smooth muscle (ASM) plays a major role in acute airway narrowing and reducing ASM thickness is expected to attenuate airway hyper‐responsiveness and disease burden. There are two therapeutic approaches to reduce ASM thickness: (a) a
Externí odkaz:
https://doaj.org/article/d28c9ca633974fb586e1904a6b151293
Autor:
Tracy S. Mann, Alexander N. Larcombe, Kimberley C. W. Wang, Danial Shamsuddin, Katherine R. Landwehr, Peter B. Noble, Peter J. Henry
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 322:L683-L698
Excessive production, secretion, and retention of abnormal mucus is a pathological feature of many obstructive airways diseases including asthma. Azithromycin is an antibiotic that also possesses immunomodulatory and mucoregulatory activities, which
Autor:
Alexander N. Larcombe, Graham M. Donovan, Peter J. Henry, Danial Shamsuddin, Kimberley C. W. Wang, Tracy S. Mann, Peter B. Noble
Publikováno v:
Physiological Reports
Physiological Reports, Vol 8, Iss 11, Pp n/a-n/a (2020)
Physiological Reports, Vol 8, Iss 11, Pp n/a-n/a (2020)
Airway smooth muscle (ASM) plays a major role in acute airway narrowing and reducing ASM thickness is expected to attenuate airway hyper‐responsiveness and disease burden. There are two therapeutic approaches to reduce ASM thickness: (a) a direct a
Autor:
Jacob Kenny, Grant Morahan, Gary J. Hoffman, Tracy S. Mann, J. Boutilier, Nigel G. Laing, Peter J. Henry, Kristen J. Nowak, Elyshia McNamara, Rodney J. Dilley, Rhonda L. Taylor
Publikováno v:
G3: Genes|Genomes|Genetics
G3: Genes, Genomes, Genetics, Vol 7, Iss 9, Pp 2999-3017 (2017)
G3: Genes, Genomes, Genetics, Vol 7, Iss 9, Pp 2999-3017 (2017)
The pulmonary myocardium is a muscular coat surrounding the pulmonary and caval veins. Although its definitive physiological function is unknown, it may have a pathological role as the source of ectopic beats initiating atrial fibrillation. How the p
Publikováno v:
Biochemical Pharmacology. 93:519-526
The airway epithelium is an important source of relaxant mediators, and damage to the epithelium caused by respiratory tract viruses may contribute to airway hyperreactivity. The aim of this study was to determine whether influenza A-induced epitheli
Publikováno v:
Biochemical Pharmacology. 89:148-156
Airway sensory C-fibres express TRPA1 channels which have recently been identified as a key chemosensory receptor for acrolein, a toxic and highly prevalent component of smoke. TRPA1 likely plays an intermediary role in eliciting a range of effects i
Early induction of uncoupling protein-2 in pulmonary macrophages in hyperoxia-associated lung injury
Autor:
Julia J Inglis, James H. Steer, David A. Joyce, Huey S Yap, Tracy S. Mann, Susan Z.Y. Lo, Peter J. Henry
Publikováno v:
Inhalation Toxicology. 25:544-552
High concentrations of inspired oxygen contribute to the pathogenesis of neonatal bronchopulmonary dysplasia and adult acute respiratory distress syndrome. Animal models of hyperoxia-associated lung injury (HALI) are characterized by enhanced generat
Publikováno v:
Respiratory Research
The hexapeptide SLIGRL-amide activates protease-activated receptor-2 (PAR-2) and mas-related G protein-coupled receptor C11 (MRGPRC11), both of which are known to be expressed on populations of sensory nerves. SLIGRL-amide has recently been reported
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 314:995-1001
Stimulants of protease-activated receptor-2 (PAR(2)), such as Ser-Leu-Ile-Gly-Arg-Leu-NH(2) (SLIGRL), cause airway smooth muscle relaxation via the release of the bronchodilatory prostanoid prostaglandin E(2) (PGE(2)). The principal aim of the curren
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 18:67-74
Asthma is a complex inflammatory disorder involving obstruction, constriction, oedema, remodelling and hyperresponsiveness of the airways. These effects are induced by a raft of mediators, many of which exert their actions by stimulating specific G-p