Výsledky vyhledávání - "Tracy Riddell"

Elucidation of a Structural Basis for the Inhibitor-Driven, p62 (SQSTM1)-Dependent Intracellular Redistribution of cAMP Phosphodiesterase-4A4 (PDE4A4)

Autor: Jana Bogum, Robert W. Allcock, Elisabeth K. Martin, Elaine Huston, Tracy Riddell, Daniel M. Houslay, Frank Christian, Miles D. Houslay, Zhong Jiang, Barbara Lindsay, Achamma Abraham, Enno Klussmann, George S. Baillie, David R. Adams, Jonathan P. Day, Sebastian Sookup, Georgina M. Rosair, Robert L. Rae, Diana F. Anthony

Publikováno v: Journal of Medicinal Chemistry. 54:3331-3347

A survey of PDE4 inhibitors reveals that some compounds trigger intracellular aggregation of PDE4A4 into accretion foci through association with the ubiquitin-binding scaffold protein p62 (SQSTM1). We show that this effect is driven by inhibitor occu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8fb40712efded0dfb998a6028221ddc
https://doi.org/10.1021/jm200070e

Zobrazit plný text záznamu

p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways

Autor: Suryakiran Vadrevu, Diana F. Anthony, Tracy Riddell, Ruth McLeod, Jonathan P. Day, Miles D. Houslay, David R. Adams, Frank Christian, George S. Baillie

Publikováno v: Cellular signalling. 22(10)

Chronic challenge of cyclic AMP phosphodiesterase-4A4 (PDE4A4) with certain PDE4 selective inhibitors causes it to reversibly form intracellular aggregates that are not membrane-encapsulated. These aggregates are neither stress granules (SGs) nor pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5011141c6524491b37e654d9dfdbf171
https://pubmed.ncbi.nlm.nih.gov/20600853

Zobrazit plný text záznamu

Psc3 cohesin of Schizosaccharomyces pombe: cell cycle analysis and identification of three distinct isoforms

Autor: Tracy Riddell, Dawid Walerych, Ramsay J. McFarlane, Jane A. Wakeman, David W. Pryce, Christopher J. McInerny, Eduard Ilyushik

Publikováno v: Biological chemistry. 386(7)

Cohesins are a group of proteins that function to mediate correct chromosome segregation, DNA repair and meiotic recombination. This report presents the amino acid sequence for theSchizosaccharomyces pombecohesin Psc3 based on the translation of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a387da5608cf29a2b58e65db4e8c2d5
https://pubmed.ncbi.nlm.nih.gov/16207082

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání