Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Tracy M. Brown"'
Autor:
Douglas E. Wood, Robert B. Nelson, Barbara G. Sahagan, Xingrong Liu, Lei Zhang, Nikolay Pozdnyakov, Jeffrey Van Deusen, Karl E.G. Richter, James E. Finley, Christine P. Parker, Karen J. Coffman, Michael Aaron Brodney, Barbara-Anne Martin, David D. Auperin, Joel B. Schachter, Dane R. Liston, Michael J. Karmilowicz, Tracy M. Brown, Barbara Tate, Christine E. Oborski, Sharon A. Sokolowski, Stacey L. Becker, Bronk Brian Scott, Thomas A. Lanz, Carol D. Hicks, Charles E. Nolan, Kathleen M. Wood
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2637-2640
A novel series of tetralin containing amino imidazoles, derived from modification of the corresponding phenyl acetic acid derivatives is described. Replacement of the amide led to identification of a potent series of tetralin-amino imidazoles with ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecedc3d6dd0ae90f3f64245736a002bc
https://doi.org/10.1016/j.bmcl.2010.12.118
https://doi.org/10.1016/j.bmcl.2010.12.118
Autor:
Kathleen M. Wood, Ping Du, Karen J. Coffman, Karl E.G. Richter, Sharon A. Sokolowski, Barbara-Anne Martin, Dane R. Liston, Barbara Tate, Douglas E. Wood, Tracy M. Brown, Michael Aaron Brodney, Carol D. Hicks, Charles E. Nolan, Nikolay Pozdnyakov, James E. Finley, Christine E. Oborski, Stacey L. Becker, Thomas A. Lanz, Kieran F. Geoghegan
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 334:269-277
PF-3084014 [(S)-2-((S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-3-ylamino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide] is a novel gamma-secretase inhibitor that reduces amyloid-beta (Abeta) production with an in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe3da18b952deeed900e3aece6d23d62
https://doi.org/10.1124/jpet.110.167379
https://doi.org/10.1124/jpet.110.167379
Autor:
Nikolay Pozdnyakov, Karen J. Coffman, Bronk Brian Scott, Douglas E. Wood, Xingrong Liu, Karl E.G. Richter, Dane R. Liston, James E. Finley, Sharon A. Sokolowski, Barbara Tate, Thomas A. Lanz, Michael Aaron Brodney, Christine E. Oborski, Jeffrey Van Deusen, Stacey L. Becker, Carol D. Hicks, Charles E. Nolan, Kathleen M. Wood, Michael J. Karmilowicz, Barbara-Anne Martin, Joel B. Schachter, Christine P. Parker, Robert B. Nelson, David D. Auperin, Barbara G. Sahagan, Tracy M. Brown
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(9)
The synthesis and structure–activity relationship (SAR) of a novel series of di-substituted imidazoles, derived from modification of DAPT, are described. Subsequent optimization led to identification of a highly potent series of inhibitors that con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf5ef01d39846e8c2950263ae44f3e4b
https://pubmed.ncbi.nlm.nih.gov/21269825
https://pubmed.ncbi.nlm.nih.gov/21269825
Publikováno v:
Alzheimer's & Dementia. 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1690bdb01b8962ad5f3440d8a3c12476
https://doi.org/10.1016/j.jalz.2010.05.695
https://doi.org/10.1016/j.jalz.2010.05.695
Autor:
Tracy M. Brown, Snehal Naik, Carol D. Hicks, Robert M. Peitzsch, Thomas T. Kawabe, Anthony J. Milici, Panayiotis Zagouras, Bradley W. Poland
Publikováno v:
Alzheimer's & Dementia. 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fb2bb23acfe578b3de0a9f128859286
https://doi.org/10.1016/j.jalz.2010.05.689
https://doi.org/10.1016/j.jalz.2010.05.689
Autor:
Anthony J. Milici, David Caouette, Tracy M. Brown, JoAnn Dumin, Holly Soares, Ashley Robshaw, Thomas T. Kawabe, Carol D. Hicks
Publikováno v:
Alzheimer's & Dementia. 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ede8a23fcf74062cd162e4930e070142
https://doi.org/10.1016/j.jalz.2010.05.713
https://doi.org/10.1016/j.jalz.2010.05.713
Autor:
Tracy M. Brown, Lida H. Kimmel, Carol D. Hicks, Paula Loos, Karl E.G. Richter, Robin J. Kleiman
Publikováno v:
Alzheimer's & Dementia. 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::646c9b1313636fab5c343e5dd74dfd91
https://doi.org/10.1016/j.jalz.2010.05.890
https://doi.org/10.1016/j.jalz.2010.05.890
Autor:
Zhiyong Xie, Tracy M. Brown, Carol D. Hicks, Thomas M.A. Bocan, Renuka Sriram, Daniel Morton, Dewen Yang, David Raunig, Diane Stephenson, Sharon M. O’Neill
Publikováno v:
NeuroImage. 54(4)
The purpose of this study was to determine if in vivo high resolution 3D MRI and localized (1)H MR spectroscopy (MRS) can detect brain findings resembling Alzheimer's disease in a transgenic mouse model of Tau pathology. Seven double transgenic rTg45
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f90e9e63640d61039becdcdc90501227
https://pubmed.ncbi.nlm.nih.gov/21035554
https://pubmed.ncbi.nlm.nih.gov/21035554
Autor:
Dewen Yang, Thomas M.A. Bocan, Zhiyong Xie, Diane Stephenson, Tracy M. Brown, Daniel Morton, Carol D. Hicks
Publikováno v:
Medical Image Computing and Computer-Assisted Intervention – MICCAI 2010 ISBN: 9783642157042
MICCAI (1)
MICCAI (1)
rTg4510 transgenic mouse model demonstrates features resembling Alzheimer's disease including neurofibrillary degeneration and progressive neuronal loss. We investigated the volumetric differences of brain structures between transgenic and wild-type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f80f4a3452a08362aed233eed336f34a
https://doi.org/10.1007/978-3-642-15705-9_38
https://doi.org/10.1007/978-3-642-15705-9_38
Autor:
Michael Marconi, Karl E.G. Richter, Christopher T. Salatto, Anthony R. Semproni, Frederick R. Nelson, Kari Schmidt, Thomas A. Lanz, Joel B. Schachter, Tracy M. Brown
Publikováno v:
Biochemical pharmacology. 75(5)
Increasing beta-amyloid (Abeta) clearance may alter the course of Alzheimer's disease progression and attenuate amyloid plaque pathology. Insulin-like growth factor I (IGF-1) augmentation has been suggested to increase Abeta clearance by facilitating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b80e59edc3bbbfd0694eb073e3727e42
https://pubmed.ncbi.nlm.nih.gov/18076866
https://pubmed.ncbi.nlm.nih.gov/18076866