Zobrazeno 1 - 10
of 192
pro vyhledávání: '"Tracy M, Handel"'
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102460- (2023)
Summary: Chemokine receptors, a subfamily of G-protein-coupled receptors (GPCRs), are responsible for cell migration during physiological processes as well as in diseases like inflammation and cancers. Here, we present a protocol for solubilizing, pu
Externí odkaz:
https://doaj.org/article/950cdfaea13d4eb6a7ac42d7d6ef23eb
Autor:
Anna L. Gray, Richard Karlsson, Abigail R.E. Roberts, Amanda J.L. Ridley, Nabina Pun, Bakhtbilland Khan, Craig Lawless, Rafael Luís, Martyna Szpakowska, Andy Chevigné, Catherine E. Hughes, Laura Medina-Ruiz, Holly L. Birchenough, Iashia Z. Mulholland, Catherina L. Salanga, Edwin A. Yates, Jeremy E. Turnbull, Tracy M. Handel, Gerard J. Graham, Thomas A. Jowitt, Ingo Schiessl, Ralf P. Richter, Rebecca L. Miller, Douglas P. Dyer
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111930- (2023)
Summary: Leukocyte recruitment from the vasculature into tissues is a crucial component of the immune system but is also key to inflammatory disease. Chemokines are central to this process but have yet to be therapeutically targeted during inflammati
Externí odkaz:
https://doaj.org/article/a86b22d342b64eea907a81850c7c8b16
Autor:
Tony Ngo, Bryan S Stephens, Martin Gustavsson, Lauren G Holden, Ruben Abagyan, Tracy M Handel, Irina Kufareva
Publikováno v:
PLoS Biology, Vol 18, Iss 4, p e3000656 (2020)
Chemokines and their receptors are orchestrators of cell migration in humans. Because dysregulation of the receptor-chemokine system leads to inflammation and cancer, both chemokines and receptors are highly sought therapeutic targets. Yet one of the
Externí odkaz:
https://doaj.org/article/d76fb27ba6414350aa8acc676fb407bc
Autor:
Martin Gustavsson, Liwen Wang, Noortje van Gils, Bryan S. Stephens, Penglie Zhang, Thomas J. Schall, Sichun Yang, Ruben Abagyan, Mark R. Chance, Irina Kufareva, Tracy M. Handel
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
The atypical chemokine receptor 3 (ACKR3) is important for cell migration in development and cancer. Here the authors combine radiolytic footprinting, disulfide trapping, mutagenesis and molecular modelling to characterize the ligand interactions and
Externí odkaz:
https://doaj.org/article/dd25b21c34a34084a772b436c75162ce
Publikováno v:
bioRxiv
Atypical chemokine receptor 3 (ACKR3) is an arrestin-biased receptor that regulates extracellular chemokine levels through scavenging. The scavenging action mediates the availability of the chemokine CXCL12 for the G protein-coupled receptor (GPCR) C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676638fcf1095a466d9f3d5af5fad1c1
https://europepmc.org/articles/PMC9980177/
https://europepmc.org/articles/PMC9980177/
Autor:
Neil J. Grimsey, Rachan Narala, Cara C. Rada, Sohum Mehta, Bryan S. Stephens, Irina Kufareva, John Lapek, David J. Gonzalez, Tracy M. Handel, Jin Zhang, JoAnn Trejo
Publikováno v:
Cell Reports, Vol 24, Iss 12, Pp 3312-3323.e5 (2018)
Summary: Ubiquitination is essential for protein degradation and signaling and pivotal to many physiological processes. Ubiquitination of a subset of G-protein-coupled receptors (GPCRs) by the E3 ligase NEDD4-2 is required for p38 activation, but how
Externí odkaz:
https://doaj.org/article/82640e8206af4d0dadef32fb621a95fe
Autor:
Douglas P. Dyer, Elisa Migliorini, Catherina L. Salanga, Dhruv Thakar, Tracy M. Handel, Ralf P. Richter
Publikováno v:
Open Biology, Vol 7, Iss 1 (2017)
Chemokines control the migration of cells in normal physiological processes and in the context of disease such as inflammation, autoimmunity and cancer. Two major interactions are involved: (i) binding of chemokines to chemokine receptors, which acti
Externí odkaz:
https://doaj.org/article/cc1a6b8bf7fb45bf82682573b6d6be1d
Autor:
Yu-Chen Yen, Christopher T. Schafer, Martin Gustavsson, Stefanie A. Eberle, Pawel K. Dominik, Dawid Deneka, Penglie Zhang, Thomas J. Schall, Anthony A. Kossiakoff, John J. G. Tesmer, Tracy M. Handel
Publikováno v:
Yen, Y-C, Schafer, C T, Gustavsson, M, Eberle, S A, Dominik, P K, Deneka, D, Zhang, P, Schall, T J, Kossiakoff, A A, Tesmer, J J G & Handel, T M 2022, ' Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias ', Science advances, vol. 8, no. 28, eabn8063 . https://doi.org/10.1126/sciadv.abn8063
Yen, Y C, Schafer, C T, Gustavsson, M, Eberle, S A, Dominik, P K, Deneka, D, Zhang, P, Schall, T J, Kossiakoff, A A, Tesmer, J J G & Handel, T M 2022, ' Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias ', Science Advances, vol. 8, no. 28, eabn8063 . https://doi.org/10.1126/sciadv.abn8063
Yen, Y C, Schafer, C T, Gustavsson, M, Eberle, S A, Dominik, P K, Deneka, D, Zhang, P, Schall, T J, Kossiakoff, A A, Tesmer, J J G & Handel, T M 2022, ' Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias ', Science Advances, vol. 8, no. 28, eabn8063 . https://doi.org/10.1126/sciadv.abn8063
Both CXC chemokine receptor 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3) are activated by the chemokine CXCL12 yet evoke distinct cellular responses. CXCR4 is a canonical G protein–coupled receptor (GPCR), whereas ACKR3 is intrinsically bias
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::924a40f0f550a39a13d9bb38b5bfa45b
https://hdl.handle.net/1871.1/baa45b22-f1c8-4c16-9abe-4570a7bcd739
https://hdl.handle.net/1871.1/baa45b22-f1c8-4c16-9abe-4570a7bcd739
Autor:
Anna L Gray, Richard Karlsson, Abigail RE Roberts, Amanda JL Ridley, Nabina Pun, Catherine Hughes, Laura Medina-Ruiz, Holly L Birchenough, Catherina L Salanga, Edwin A Yates, Jeremy E Turnbull, Tracy M Handel, Gerard J Graham, Thomas A Jowitt, Ingo Schiessl, Ralf P Richter, Rebecca L Miller, Douglas P Dyer
Leukocyte recruitment from the vasculature into tissues is a crucial component of the immune system, but is also key to inflammatory disease. Chemokines are central to this process but have yet to be therapeutically targeted during inflammation, due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc5fb4e6554a81b5b523e626b0e78da4
https://doi.org/10.1101/2022.07.10.499282
https://doi.org/10.1101/2022.07.10.499282
Autor:
Yu‐Chen Yen, Christopher T. Schafer, Martin Gustavsson, Stefanie A. Eberle, Pawel K. Dominik, Dawid Deneka, Penglie Zhang, Thomas J. Schall, Anthony A. Kossiakoff, Tracy M. Handel, John J. Tesmer
Publikováno v:
The FASEB Journal. 36