Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Tracy L. Young‐Pearse"'
Autor:
Andrew J. White, Karis A. Clark, Kellianne D. Alexander, Nagendran Ramalingam, Tracy L. Young-Pearse, Ulf Dettmer, Dennis J. Selkoe, Gary P. H. Ho
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-8 (2024)
Abstract Alpha-synuclein (αS)-rich Lewy bodies and neurites in the cerebral cortex correlate with the presence of dementia in Parkinson disease (PD) and Dementia with Lewy bodies (DLB), but whether αS influences synaptic vesicle dynamics in human c
Externí odkaz:
https://doaj.org/article/d786b0ee3bd14339a2ed5d540b37e70d
Autor:
Vicky Chou, Richard V. Pearse, Aimee J. Aylward, Nancy Ashour, Mariko Taga, Gizem Terzioglu, Masashi Fujita, Seeley B. Fancher, Alina Sigalov, Courtney R. Benoit, Hyo Lee, Matti Lam, Nicholas T. Seyfried, David A. Bennett, Philip L. De Jager, Vilas Menon, Tracy L. Young-Pearse
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract Microglia and neuroinflammation play an important role in the development and progression of Alzheimer’s disease (AD). Inositol polyphosphate-5-phosphatase D (INPP5D/SHIP1) is a myeloid-expressed gene genetically-associated with AD. Throug
Externí odkaz:
https://doaj.org/article/9e3d8cd8d32347f6b00af0ac1594f3b7
Autor:
Gizem Terzioglu, Tracy L. Young-Pearse
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-18 (2023)
Abstract Recent genetic studies on Alzheimer’s disease (AD) have brought microglia under the spotlight, as loci associated with AD risk are enriched in genes expressed in microglia. Several of these genes have been recognized for their central role
Externí odkaz:
https://doaj.org/article/455c78a0745140dc96b056787c1a1d90
Autor:
Lien D. Nguyen, Zhiyun Wei, M. Catarina Silva, Sergio Barberán-Soler, Jiarui Zhang, Rosalia Rabinovsky, Christina R. Muratore, Jonathan M. S. Stricker, Colin Hortman, Tracy L. Young-Pearse, Stephen J. Haggarty, Anna M. Krichevsky
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract MicroRNAs (miRNAs) regulate fundamental biological processes by silencing mRNA targets and are dysregulated in many diseases. Therefore, miRNA replacement or inhibition can be harnessed as potential therapeutics. However, existing strategies
Externí odkaz:
https://doaj.org/article/b8a8e54f65f640bfad7b904c07567fde
Autor:
Julie P. Merchant, Kuixi Zhu, Marc Y. R. Henrion, Syed S. A. Zaidi, Branden Lau, Sara Moein, Melissa L. Alamprese, Richard V. Pearse, David A. Bennett, Nilüfer Ertekin-Taner, Tracy L. Young-Pearse, Rui Chang
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-19 (2023)
Abstract Despite decades of genetic studies on late-onset Alzheimer’s disease, the underlying molecular mechanisms remain unclear. To better comprehend its complex etiology, we use an integrative approach to build robust predictive (causal) network
Externí odkaz:
https://doaj.org/article/59af61a1276a4d158efbd9462249793a
Autor:
Zemin Wang, Ming Jin, Wei Hong, Wen Liu, David Reczek, Valentina N. Lagomarsino, Yuan Hu, Tim Weeden, Matthew P. Frosch, Tracy L. Young-Pearse, Laurent Pradier, Dennis Selkoe, Dominic M. Walsh
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-20 (2023)
Abstract Despite ongoing debate, the amyloid β-protein (Aβ) remains the prime therapeutic target for the treatment of Alzheimer’s disease (AD). However, rational drug design has been hampered by a lack of knowledge about neuroactive Aβ. To help
Externí odkaz:
https://doaj.org/article/a44ed862eab649ab94c4fe38529e56d1
Autor:
Yi-Chen Hsieh, Joseph Negri, Amy He, Richard V. Pearse, Lei Liu, Duc M. Duong, Lori B. Chibnik, David A. Bennett, Nicholas T. Seyfried, Tracy L. Young-Pearse
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-23 (2022)
Abstract Background Alzheimer’s Disease (AD) affects millions globally, but therapy development is lagging. New experimental systems that monitor neuronal functions in conditions approximating the AD brain may be beneficial for identifying new ther
Externí odkaz:
https://doaj.org/article/6be3dc2f5fd24619b28eb8ec75d45782
Autor:
Hyo Lee, Aimee J. Aylward, Richard V. Pearse, II, Alexandra M. Lish, Yi-Chen Hsieh, Zachary M. Augur, Courtney R. Benoit, Vicky Chou, Allison Knupp, Cheryl Pan, Srilakshmi Goberdhan, Duc M. Duong, Nicholas T. Seyfried, David A. Bennett, Mariko F. Taga, Kevin Huynh, Matthias Arnold, Peter J. Meikle, Philip L. De Jager, Vilas Menon, Jessica E. Young, Tracy L. Young-Pearse
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112994- (2023)
Summary: SORL1 is implicated in the pathogenesis of Alzheimer’s disease (AD) through genetic studies. To interrogate the roles of SORL1 in human brain cells, SORL1-null induced pluripotent stem cells (iPSCs) were differentiated to neuron, astrocyte
Externí odkaz:
https://doaj.org/article/911ab12d4ed045b69c2a0c7474867a7a
Autor:
Heather C. Rice, Gabriele Marcassa, Iordana Chrysidou, Katrien Horré, Tracy L. Young-Pearse, Ulrike C. Müller, Takashi Saito, Takaomi C. Saido, Robert Vassar, Joris de Wit, Bart De Strooper
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-8 (2020)
Abstract The amyloid-β (Aβ) peptide, the primary constituent of amyloid plaques found in Alzheimer’s disease (AD) brains, is derived from sequential proteolytic processing of the Amyloid Precursor Protein (APP). However, the contribution of diffe
Externí odkaz:
https://doaj.org/article/5d37cdfea3af48149a9c42e6eadd3cbc
Autor:
Christina R. Muratore, Constance Zhou, Meichen Liao, Marty A. Fernandez, Walter M. Taylor, Valentina N. Lagomarsino, Richard V. Pearse, II, Heather C. Rice, Joseph M. Negri, Amy He, Priya Srikanth, Dana G. Callahan, Taehwan Shin, Monica Zhou, David A. Bennett, Scott Noggle, J. Christopher Love, Dennis J. Selkoe, Tracy L. Young-Pearse
Publikováno v:
Stem Cell Reports, Vol 9, Iss 6, Pp 1868-1884 (2017)
Summary: Alzheimer's disease (AD) induces memory and cognitive impairment in the absence of motor and sensory deficits during its early and middle course. A major unresolved question is the basis for this selective neuronal vulnerability. Aβ, whic
Externí odkaz:
https://doaj.org/article/9f03abb62b1343ab8aa8f519af659d78