Defining the inflammatory signature of human lung explant tissue in the presence and absence of glucocorticoid [version 1; referees: 2 approved]

Autor: Tracy L Rimington, Emily Hodge, Charlotte K Billington, Sangita Bhaker, Binaya K C, Iain Kilty, Scott Jelinsky, Ian P Hall, Ian Sayers

Publikováno v: F1000Research, Vol 6 (2017)

Background: Airway inflammation is a feature of many respiratory diseases and there is a need for newer, more effective anti-inflammatory compounds. The aim of this study was to develop an ex vivo human lung explant model which can be used to help st

Externí odkaz: https://doaj.org/article/2beaa65a72814bba8b062eba6979408a

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

Autor: Stefan Enroth, Robert J. Hall, James D. Crapo, Frederick E. Dewey, Victoria E. Jackson, Eleftheria Zeggini, Gudmar Thorleifsson, Terho Lehtimäki, David J. Porteous, Nicole Probst-Hensch, Ian J. Deary, A. Mesut Erzurumluoglu, Bram P. Prins, Maarten van den Berge, Craig E. Pennell, Catherine John, Terri H. Beaty, Claudia Schurmann, Michael H. Cho, Veronique Vitart, Erwin P. Bottinger, Carol A. Wang, H. Lester Kirchner, Medea Imboden, David J. Carey, Archie Campbell, Kari Stefansson, Matthias Wielscher, Ida Surakka, Igor Rudan, Shona M. Kerr, Holger Schulz, Michael A. Portelli, Thorarinn Gislason, Peter D. Paré, James F. Wilson, Boris Noyvert, Beate Stubbe, Zhengming Chen, Ruth J. F. Loos, Ma'en Obeidat, María Soler Artigas, Philippe Joubert, Kathleen C. Barnes, Christian Gieger, Andrew P. Morris, Rajesh Rawal, Yohan Bossé, Peter K. Joshi, Nadia N. Hansel, Emily S. Wan, David M. Evans, David C. Nickle, Caroline Hayward, Stefan Karrasch, Ke Hao, Tracy L. Rimington, Don D. Sin, Alan James, Stefan Jonsson, Shannon Bruse, Amanda P. Henry, Iona Y Millwood, Lara Bossini-Castillo, Ian P. Hall, David Sparrow, Ulf Gyllensten, Ian Sayers, Edwin K. Silverman, Robert Busch, David P. Strachan, Martin D. Tobin, Nick Shrine, Louise V. Wain, Robin G. Walters, Ingileif Jonsdottir, Peter D. Sly, Liming Li, Charlotte K. Billington, Anna Hansell, Omri Gottesman, Om P Kurmi, Ingo Ruczinski, Nicholas J. Wareham, Amund Gulsvik, Per Bakke, Jennie Hui, Corry-Anke Brandsma, Gosia Trynka, Anthony G. Fenech, Brian D. Hobbs, A. John Henderson, Jonathan Marten, Olli T. Raitakari, Richard J. Allen, Augusto A. Litonjua, Sarah E. Harris, Ozren Polasek, Mika Kähönen, Tineka Blake, Marjo-Riitta Järvelin, Rasika A. Mathias, Jing Hua Zhao, Julien Vaucher, Girish N. Nadkarni, Christopher E. Brightling

Publikováno v: Nature Genetics, 49(3), 416-425. Nature Publishing Group
Nat. Genet. 49, 416-425 (2017)
Nature genetics
Wain, L V, Shrine, N, Artigas, M S, Erzurumluoglu, A M, Noyvert, B, Bossini-Castillo, L, Obeidat, ME, Henry, A P, Portelli, M A, Hall, R J, Billington, C K, Rimington, T L, Fenech, A G, John, C, Blake, T, Jackson, V E, Allen, R J, Prins, B P, Campbell, A, Porteous, D J, Jarvelin, M R, Wielscher, M, James, A L, Hui, J, Wareham, N J, Zhao, J H, Wilson, J F, Joshi, P K, Stubbe, B, Rawal, R, Schulz, H, Imboden, M, Probst-Hensch, N M, Karrasch, S, Gieger, C, Deary, I J, Harris, S E, Marten, J, Rudan, I, Enroth, S, Gyllensten, U, Kerr, S M, Polasek, O, Kähönen, M, Surakka, I, Vitart, V, Hayward, C, Lehtimäki, T, Raitakari, O T, Evans, D M, Henderson, A J, Pennell, C E, Wang, C A, Sly, P D, Wan, E S, Busch, R, Hobbs, B D, Litonjua, A A, Sparrow, D W, Gulsvik, A, Bakke, P S, Crapo, J D, Beaty, T H, Hansel, N N, Mathias, R A, Ruczinski, I, Barnes, K C, Bossé, Y, Joubert, P, Van Den Berge, M, Brandsma, C A, Paré, P D, Sin, D D, Nickle, D C, Hao, K, Gottesman, O, Dewey, F E, Bruse, S E, Carey, D J, Kirchner, H L, Jonsson, S, Thorleifsson, G, Jonsdottir, I, Gislason, T, Stefansson, K, Schurmann, C, Nadkarni, G, Bottinger, E P, Loos, R J F, Walters, R G, Chen, Z, Millwood, I Y, Vaucher, J, Kurmi, O P, Li, L, Hansell, A L, Brightling, C, Zeggini, E, Cho, M H, Silverman, E K, Sayers, I, Trynka, G, Morris, A P, Strachan, D P, Hall, I P & Tobin, M 2017, ' Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets ', Nature Genetics, vol. 49, no. 3, pp. 416-425 . https://doi.org/10.1038/ng.3787
Wain, L V, Shrine, N, Artigas, M S, Erzurumluoglu, A M, Noyvert, B, Bossini-Castillo, L, Obeidat, M, Henry, A P, Portelli, M A, Hall, R J, Billington, C K, Rimington, T L, Fenech, A G, John, C, Blake, T, Jackson, V E, Allen, R J, Prins, B P, Campbell, A, Porteous, D J, Jarvelin, M-R, Wielscher, M, James, A L, Hui, J, Wareham, N J, Zhao, J H, Wilson, J F, Joshi, P K, Stubbe, B, Rawal, R, Schulz, H, Imboden, M, Probst-Hensch, N M, Karrasch, S, Gieger, C, Deary, I J, Harris, S E, Marten, J, Rudan, I, Enroth, S, Gyllensten, U, Kerr, S M, Polasek, O, Kähönen, M, Surakka, I, Vitart, V, Hayward, C, Lehtimäki, T & Raitakari, O T & Morris, A P 2017, ' Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets ', Nature Genetics, vol. 49, no. 3, pp. 416-425 . https://doi.org/10.1038/ng.3787
Nature Genetics

Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function and is the third leading cause of death globally. Through genome-wide association discovery in 48,943 individuals, selected from extremes of the lung function dist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eeee8ba2c3ce7b48422702e6d914f26
https://doi.org/10.1038/ng.3787

The Ser82 RAGE variant affects lung function and serum RAGE in smokers and sRAGE production in vitro

Autor: Charlotte K. Billington, Tracy L. Rimington, Ceri E. Stewart, Ian P. Hall, Iain Kilty, Catherine Gowland, Simon Kebede Merid, Andrew J. Wardlaw, Caroline Swan, Erik Melén, Ian Sayers, Sangita Bhaker, Charlotte E. Bolton, Anders Mälarstig, Stuart G Parker, Abdul Kader Kheirallah, Amanda P. Henry, Carl P. Nelson, Suzanne Miller, Ma'en Obeidat, Emily Hodge, Miriam F. Moffatt

Publikováno v: PLoS ONE
PLoS ONE, Vol 11, Iss 10, p e0164041 (2016)

Introduction:\ud Genome-Wide Association Studies have identified associations between lung function measures and Chronic Obstructive Pulmonary Disease (COPD) and chromosome region 6p21 containing the gene for the Advanced Glycation End Product Recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::802d73c51ae1801579a966f85556e295
https://irep.ntu.ac.uk/id/eprint/29060/1/PubSub6566_Nelson.PDF

Characterizing diverse orthologues of the cystic fibrosis transmembrane conductance regulator protein for structural studies.

Autor: Pollock, Naomi L., Rimington, Tracy L., Ford, Robert C.

Publikováno v: Biochemical Society Transactions; Oct2015, Vol. 43 Issue 5, p894-900, 7p