Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Tracy L McGaha"'
Autor:
Vibha Jha, Creg J Workman, Tracy L McGaha, Liping Li, Jaya Vas, Dario A A Vignali, Marc Monestier
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104484 (2014)
Environmental factors including drugs, mineral oils and heavy metals such as lead, gold and mercury are triggers of autoimmune diseases in animal models or even in occupationally exposed humans. After exposure to subtoxic levels of mercury (Hg), gene
Externí odkaz:
https://doaj.org/article/5c1115ec90f34be88e60808ad7e01a85
Autor:
Mengdi Guo, Diala Abd-Rabbo, Bruna C. Bertol, Madeleine Carew, Sabelo Lukhele, Laura M. Snell, Wenxi Xu, Giselle M. Boukhaled, Heidi Elsaesser, Marie Jo Halaby, Naoto Hirano, Tracy L. McGaha, David G. Brooks
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113047- (2023)
Summary: CD4 T cells are central effectors of anti-cancer immunity and immunotherapy, yet the regulation of CD4 tumor-specific T (TTS) cells is unclear. We demonstrate that CD4 TTS cells are quickly primed and begin to divide following tumor initiati
Externí odkaz:
https://doaj.org/article/e4149f45150d4ef1af757d28b5084332
Autor:
Marie Jo Halaby, Tracy L. McGaha
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Regulation of amino acid availability and metabolism in immune cells is essential for immune system homeostasis and responses to exogenous and endogenous challenges including microbial infection, tumorigenesis and autoimmunity. In myeloid cells the c
Externí odkaz:
https://doaj.org/article/675bd9ec60f046f8bae4ddd60a8d75a0
Autor:
Mengdi Guo, Diala Abd-Rabbo, Bruna Bertol, Madeleine Carew, Sabelo Lukhele, Laura M Snell, Wenxi Xu, Giselle M Boukhaled, Heidi Elsaesser, Marie jo Halaby, Naoto Hirano, Tracy L McGaha, David G Brooks
Publikováno v:
bioRxiv
CD4 T cells are important effectors of anti-tumor immunity, yet the regulation of CD4 tumor-specific T (TTS) cells during cancer development is still unclear. We demonstrate that CD4 TTScells are initially primed in the tumor draining lymph node and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc68d8039b703b05f19324e33bbb107
https://europepmc.org/articles/PMC10153152/
https://europepmc.org/articles/PMC10153152/
Autor:
Steven Gallinger, George Zogopoulos, Yifan Wang, Ashton Connor, Jennifer J. Knox, Julie M. Wilson, Grainne M. O'Kane, Susan J. Done, Pamela S. Ohashi, Faiyaz Notta, Tracy L. McGaha, Rama Khokha, Peter Bronsert, Foram Vyas, Dianne Chadwick, Sheng-Ben Liang, Sharon Dhaliwal, Niandong Li, Jing Xu, John M.S. Bartlett, Angela De Luca, Ilinca M. Lungu, Robert E. Denroche, Amy Zhang, Sandra E. Fischer, Mehdi Masoomian, Aaditeya Jhaveri, Prashant P. Bavi, Gun-Ho Jang, Barbara Grünwald, Joan M. Romero
Supplementary Figure 3: Association of chemokine expression with a T cell-inflamed phenotype was validated in a second independent PDAC patient cohort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2148a577fe64176830f0b01dcfd519
https://doi.org/10.1158/1078-0432.22477580
https://doi.org/10.1158/1078-0432.22477580
Autor:
Steven Gallinger, George Zogopoulos, Yifan Wang, Ashton Connor, Jennifer J. Knox, Julie M. Wilson, Grainne M. O'Kane, Susan J. Done, Pamela S. Ohashi, Faiyaz Notta, Tracy L. McGaha, Rama Khokha, Peter Bronsert, Foram Vyas, Dianne Chadwick, Sheng-Ben Liang, Sharon Dhaliwal, Niandong Li, Jing Xu, John M.S. Bartlett, Angela De Luca, Ilinca M. Lungu, Robert E. Denroche, Amy Zhang, Sandra E. Fischer, Mehdi Masoomian, Aaditeya Jhaveri, Prashant P. Bavi, Gun-Ho Jang, Barbara Grünwald, Joan M. Romero
Supplementary Table 1: Top 99 genes associating with CD8+ TIL counts in primary resected cases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9ad799ac3e5f88e9b54d93aa5a0fd99
https://doi.org/10.1158/1078-0432.22477568.v1
https://doi.org/10.1158/1078-0432.22477568.v1
Autor:
Steven Gallinger, George Zogopoulos, Yifan Wang, Ashton Connor, Jennifer J. Knox, Julie M. Wilson, Grainne M. O'Kane, Susan J. Done, Pamela S. Ohashi, Faiyaz Notta, Tracy L. McGaha, Rama Khokha, Peter Bronsert, Foram Vyas, Dianne Chadwick, Sheng-Ben Liang, Sharon Dhaliwal, Niandong Li, Jing Xu, John M.S. Bartlett, Angela De Luca, Ilinca M. Lungu, Robert E. Denroche, Amy Zhang, Sandra E. Fischer, Mehdi Masoomian, Aaditeya Jhaveri, Prashant P. Bavi, Gun-Ho Jang, Barbara Grünwald, Joan M. Romero
Purpose:The molecular drivers of antitumor immunity in pancreatic ductal adenocarcinoma (PDAC) are poorly understood, posing a major obstacle for the identification of patients potentially amenable for immune-checkpoint blockade or other novel strate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd84bdb51ce83612e777db5ee31b4677
https://doi.org/10.1158/1078-0432.c.6529700
https://doi.org/10.1158/1078-0432.c.6529700
Autor:
Bethany L. MacLeod, W. Xu, Giselle Boukhaled, Sabelo Lukhele, Diala Abd-Rabbo, Mengdi Guo, Laura M. Snell, Sara Nejat, Heidi Elsaesser, Tracy L. McGaha, Slava Epelman, Kebria Hezaveh, David G. Brooks, Ramanandan Prabhakaran, Nirmin Alsahafi
Publikováno v:
Nature Immunology. 22:1524-1537
Inhibiting PD-1:PD-L1 signaling has transformed therapeutic immune restoration. CD4+ T cells sustain immunity in chronic infections and cancer, yet little is known about how PD-1 signaling modulates CD4+ helper T (TH) cell responses or the ability to
Autor:
Lillian L. Siu, Samah El Ghamrasni, Aaron R. Hansen, Pamela S. Ohashi, David G. Brooks, Benjamin Haibe-Kains, Alexey Aleshin, S. Y. Cindy Yang, Hal K. Berman, Marc Oliva, Stephanie Lheureux, Albiruni Ryan Abdul Razak, Scott V. Bratman, Kelsey Zhu, Ben X. Wang, Jeff Bruce, Marco A. J. Iafolla, Tracy L. McGaha, Marcus O. Butler, Youstina Hanna, Anna Spreafico, Philippe L. Bedard, Scott C. Lien, Trevor J. Pugh, Derek L. Clouthier, Iulia Cirlan, Vanessa Speers
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Serial circulating tumor DNA (ctDNA) monitoring is emerging as a non-invasive strategy to predict and monitor immune checkpoint blockade (ICB) therapeutic efficacy across cancer types. Yet, limited data exist to show the relationship between ctDNA dy
Autor:
Priya, Makhijani, Tracy L, McGaha
Publikováno v:
Frontiers in Immunology. 13
Extracellular vesicles are mediators of cell-cell communication playing a key role in both steady-state and disease conditions. Extracellular vesicles carry diverse donor-derived cargos, including DNA, RNA, proteins, and lipids that induce a complex