Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Tracy L Diamond"'
Autor:
Frederic D Bushman, Nirav Malani, Jason Fernandes, Iván D'Orso, Gerard Cagney, Tracy L Diamond, Honglin Zhou, Daria J Hazuda, Amy S Espeseth, Renate König, Sourav Bandyopadhyay, Trey Ideker, Stephen P Goff, Nevan J Krogan, Alan D Frankel, John A T Young, Sumit K Chanda
Publikováno v:
PLoS Pathogens, Vol 5, Iss 5, p e1000437 (2009)
We have analyzed host cell genes linked to HIV replication that were identified in nine genome-wide studies, including three independent siRNA screens. Overlaps among the siRNA screens were very modest (
Externí odkaz:
https://doaj.org/article/8367ca4bba4e49f2bad41a3007e87ed2
Autor:
Carl J. Balibar, Daniel J. Klein, Beata Zamlynny, Tracy L. Diamond, Zhiyu Fang, Carol A. Cheney, Jan Kristoff, Meiqing Lu, Marina Bukhtiyarova, Yangsi Ou, Min Xu, Lei Ba, Steven S. Carroll, Abdellatif El Marrouni, John F. Fay, Ashley Forster, Shih Lin Goh, Meigang Gu, Daniel Krosky, Daniel I. S. Rosenbloom, Payal Sheth, Deping Wang, Guoxin Wu, Matthias Zebisch, Tian Zhao, Paul Zuck, Jay Grobler, Daria J. Hazuda, Bonnie J. Howell, Antonella Converso
Publikováno v:
Science Translational Medicine. 15
Antiretroviral therapy inhibits HIV-1 replication but is not curative due to establishment of a persistent reservoir after virus integration into the host genome. Reservoir reduction is therefore an important HIV-1 cure strategy. Some HIV-1 nonnucleo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::512a144edadcb09a3ad7b6560f3b8bab
https://doi.org/10.1126/scitranslmed.abn2038
https://doi.org/10.1126/scitranslmed.abn2038
Autor:
Antonella Converso, Richard J. O. Barnard, David M. Tellers, Abdellatif El Marrouni, Scott E. Wolkenberg, Tracy L. Diamond
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c32139df209fcc18132f6cfa686ae363
https://doi.org/10.1002/0471266949.bmc281
https://doi.org/10.1002/0471266949.bmc281
Autor:
Tracy L. Diamond, Winnie Ngo, Min Xu, Shih Lin Goh, Silveria Rodriguez, Ming-Tain Lai, Ernest Asante-Appiah, Jay A. Grobler
Publikováno v:
Antimicrob Agents Chemother
Islatravir (ISL) is a nucleoside reverse transcriptase translocation inhibitor (NRTTI) that inhibits human immunodeficiency virus (HIV) reverse transcription by blocking reverse transcriptase (RT) translocation on the primer:template. ISL is being de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93972fb718323bf1419e15e05e1a3b9d
https://europepmc.org/articles/PMC9211433/
https://europepmc.org/articles/PMC9211433/
Autor:
Ming-Tain Lai, Meizhen Feng, Min Xu, Winnie Ngo, Tracy L. Diamond, Carey Hwang, Jay A. Grobler, Daria J. Hazuda, Ernest Asante-Appiah
Publikováno v:
Antimicrob Agents Chemother
Doravirine (DOR), a non-nucleoside reverse transcriptase inhibitor (NNRTI), was approved for treatment of HIV-1 infection in 2018. In the pivotal phase 3 trials, DRIVE-FORWARD and DRIVE-AHEAD, 7 out of 747 (0.9%) treatment-naive participants treated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcbbe7a8bb197cfd2b944cf714b8939f
https://pubmed.ncbi.nlm.nih.gov/35491829
https://pubmed.ncbi.nlm.nih.gov/35491829
Autor:
Carolyn Bahnck-Teets, Xu Min, Lehua Chang, Tracy L. Diamond, M. Katharine Holloway, John F. Fay, David Jonathan Bennett, John A. Mccauley, Jurgen Schulz, Marie Loughran, Peter D. Williams, Alejandro Crespo, Andrew Stamford, Hua-Poo Su, Michael D. Miller, Kartik M. Keertikar, Christopher J. Bungard, Catherine M. Wiscount, Bin Zhong, Jeanine E. Ballard, Sherman T. Waddell, Steven S. Carroll, Tao Ji, Jesse J. Manikowski, Bin Hu, Xin-jie Chu, Gregori J. Morriello, William J. Morris, Michael P. Dwyer
Publikováno v:
ACS Medicinal Chemistry Letters. 8:1292-1297
Using the HIV-1 protease binding mode of MK-8718 and PL-100 as inspiration, a novel aspartate binding bicyclic piperazine sulfonamide core was designed and synthesized. The resulting HIV-1 protease inhibitor containing this core showed an 60-fold inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6240d0128d9c35a558caa2cfbba15fa5
https://doi.org/10.1021/acsmedchemlett.7b00386
https://doi.org/10.1021/acsmedchemlett.7b00386
Autor:
James C. Hershey, Youheng Shu, Cheng Wang, Julie A. O'Brien, Vanita Puri, Tracy L. Diamond, Shaei Huang, Antonella Converso, Brian C. Magliaro, Jason M. Uslaner, Victor N. Uebele, Kelly-Ann S. Schlegel
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(9)
Antagonism of the mGluR2 receptor has the potential to provide therapeutic benefit to cognitive disorders by elevating synaptic glutamate, the primary excitatory neurotransmitter in the brain. Selective antagonism of the mGluR2 receptor, however, has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60318faea5edce68a4bf4762b8f54575
https://pubmed.ncbi.nlm.nih.gov/32173198
https://pubmed.ncbi.nlm.nih.gov/32173198
Autor:
Steven S. Carroll, Jeffrey Heath, Antonella Converso, John M. Sanders, Tracy L. Diamond, Kartik Narayan, Mee Ra Heo, Mark W. Stahlhut, Triveni Bhatt, Min Xu, Daniel Krosky, Christine Burlein, Pravien Abeywickrema, Jay A. Grobler, Daniel J. Klein, Yangsi Ou, Gregory C. Adam, Cheng Wang, Sujata Sharma
Publikováno v:
ACS chemical biology. 12(11)
Allosteric integrase inhibitors (ALLINIs) bind to the lens epithelial-derived growth factor (LEDGF) pocket on HIV-1 integrase (IN) and possess potent antiviral effects. Rather than blocking proviral integration, ALLINIs trigger IN conformational chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebbd532ce75aab6532455cdef64c2b52
https://pubmed.ncbi.nlm.nih.gov/29024587
https://pubmed.ncbi.nlm.nih.gov/29024587
Autor:
Li Hao, Carolyn Bahnck-Teets, Catherine M. Wiscount, Daniel J. McKay, Carmela Molinaro, Ronald K. Chang, S S Carroll, Sivalenka Vijayasaradhi, Philippe G. Nantermet, Sanjay Kumar Singh, Christopher J. Bungard, Dubost David C, David Jonathan Bennett, Thomas J. Greshock, Hua-Poo Su, Rosa I. Sanchez, Vouy Linh Truong, Xu Min, John F. Fay, Jeanine E. Ballard, John A. McCauley, Christian Beaulieu, M. Katharine Holloway, Joseph P. Vacca, Michael W. Miller, Tummanapalli Satyanarayana, Sheldon Crane, William D. Shipe, Jesse J. Manikowski, Peter D. Williams, Christian Nadeau, Jennifer J. Gesell, Tracy L. Diamond, Peter J. Felock, Oscar Miguel Moradei
A novel HIV protease inhibitor was designed using a morpholine core as the aspartate binding group. Analysis of the crystal structure of the initial lead bound to HIV protease enabled optimization of enzyme potency and antiviral activity. This afford
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f685aed82b9b428b5b9e7330d8f427
https://europepmc.org/articles/PMC4948015/
https://europepmc.org/articles/PMC4948015/
Publikováno v:
The Journal of Biological Chemistry
Integrase (IN) is the catalytic component of the preintegration complex, a large nucleoprotein assembly critical for the integration of the retroviral genome into a host chromosome. Although partial crystal structures of human immunodeficiency virus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef622ead1259af683a6f025d9c781cc
https://doi.org/10.1074/jbc.m110.114413
https://doi.org/10.1074/jbc.m110.114413