Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Tracy J. Ringer"'
Autor:
Maddux Todd Michael, Yvette M. Fobian, Alan G. Benson, Dafydd R. Owen, Brian R. Bond, Christopher Phillips, Brad A. Acker, E. Jon Jacobsen, Michael John Palmer, D. Joseph Rogier, John M. Molyneaux, Brent V. Mischke, John N. Freskos, Tracy J. Ringer, Andrew Simon Bell, Blevis-Bal Radhika M, Robert Hughes, David G. Brown, Steve E. Heasley, Joseph B. Moon, John K. Walker, Brown David L, William C. Stallings, Michael B. Tollefson, Alan MacInnes, Jerry W. Cubbage, Yung Yu, Margarita Rodriquez-Lens, Fox David Nathan Abraham
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4088-4091
A new class of potent and selective PDE5 inhibitors is disclosed. Guided by X-ray crystallographic data, optimization of an HTS lead led to the discovery of a series of 2-aryl, (N8)-alkyl substituted-6-aminosubstituted pyrido[3,2b]pyrazinones which s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5005db6742e606fdadbf520ea66a63a9
https://doi.org/10.1016/j.bmcl.2009.06.012
https://doi.org/10.1016/j.bmcl.2009.06.012
Autor:
Steven M. Gaulier, Dafydd R. Owen, Margarita Rodriguez-Lens, Huw Rees, Valerie A. Horne, Blanda Luzia Christa Stammen, Martin Corless, Maw Graham Nigel, Thomas Ryckmans, David W. Pearce, Ross A. Kinloch, Tracy J. Ringer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1702-1706
A number of libraries were produced to explore the potential of 2,4-diaminopyridine lead 1. The resulting diaminopyridines proved to be potent and selective delta-opioid receptor agonists. Several rounds of lead optimisation using library chemistry i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c4f65a97e449b1a91cdfa17bc9358fc
https://doi.org/10.1016/j.bmcl.2009.01.106
https://doi.org/10.1016/j.bmcl.2009.01.106
Autor:
Kevin Beaumont, Dafydd R. Owen, Kenneth John Butcher, Stephen J. Holland, Julian Blagg, Tracy J. Ringer, Robert Moore, John Steele, Miller Duncan Charles, Andrew J. Gray, Mark E. Bunnage, Charlotte Moira Norfor Allerton, Neil Feeder, Andrew B. McElroy, Karen Evans, David G. Brown
Publikováno v:
Journal of Medicinal Chemistry. 50:6095-6103
Thrombin-activatable fibrinolysis inhibitor (TAFI) has emerged as a key link between the coagulation and fibrinolysis cascades and represents a promising new target for the treatment of thrombosis. A novel series of imidazolepropionic acids has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a240b87c092af2dc8ebedc122ac950f
https://doi.org/10.1021/jm0702433
https://doi.org/10.1021/jm0702433
Autor:
Simon Gayton, Graham Smith, Dafydd R. Owen, Gareth W. Harbottle, Tracy J. Ringer, Maw Graham Nigel, Simon A. Osborne, Margarita Rodriguez-Lens, Huw Rees, Peter G. Dodd, Ben S. Greener, Simon John Mantell
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:486-490
A series of novel mGluR1 antagonists have been prepared. Incorporation of fragments derived from weak lead matter into a library led to enhanced potency in a new chemical series. A chemistry driven second library iteration, covering a greatly enhance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9542eb7964fd6a3b5aa1b6c9a6e4b0a
https://doi.org/10.1016/j.bmcl.2006.10.015
https://doi.org/10.1016/j.bmcl.2006.10.015
Autor:
Dack Kevin Neil, Fox David Nathan Abraham, Strang Ross Sinclair, Dafydd R. Owen, Keith A. Reeves, Melanie S. Glossop, Graeme Arthur Macdonald, Christopher Phillips, Christine Anne Louise Watson, Mark Mills, Richard Bazin, Tracy J. Ringer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3404-3406
Heteroarylalanine derivatives 4 were designed as potential inhibitors of neutral endopeptidase (NEP EC 3.4.24.11). Selectivity over other zinc metalloproteinases was explored through occupation of the S2′ subsite within NEP. Structural optimisation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5699785823bf7067227ef1f304784fa6
https://doi.org/10.1016/j.bmcl.2011.03.109
https://doi.org/10.1016/j.bmcl.2011.03.109