Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Tracy I. Stevenson"'
Autor:
J. David Baker, Tracy I. Stevenson, Douglas A. Gage, Sam Donohoe, Erin E. Brzezinski, Mark P. Molloy, David R. Goodlett, Greg W. Kilby
Publikováno v:
PROTEOMICS. 5:1204-1208
Strategies employing non-gel based methods for quantitative proteomic profiling such as isotope coded affinity tags coupled with mass spectrometry (ICAT-MS) are gaining attention as alternatives to two-dimensional gel electrophoresis (2-DE). We have
Autor:
Ming Xian, Zakia Fatima, Wei Zhang, Tracy I. Stevenson, Dehua Pei, Peng George Wang, Jianwen Fang, Hanfen Li, Joseph A. Loo
Publikováno v:
Journal of Combinatorial Chemistry. 6:126-134
A general methodology has been established for rapid generation and screening of combinatorial glycopeptide library and subsequent mass spectrometric sequencing to identify the mimetics of Galalpha(1,3)Gal epitopes. Using this approach, several activ
Autor:
Greg W. Kilby, Tracy I. Stevenson, Beth McGee, Joseph Macri, John N. Thomas, Ping Du, Stephen T. Rapundalo
Publikováno v:
Electrophoresis. 21:1685-1693
We evaluated the use of the alkyaryl amidosulfobetaine zwitterionic detergent, designated as C8psi, to facilitate the solubilization of cardiac subcellular, membrane-associated proteins. Hearts from 7-week-old male Sprague-Dawley rats were isolated,
Publikováno v:
Medicinal Research Reviews. 19:307-319
Mass spectrometry-based methodologies span the vast expanse of drug discovery. Both electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI) support proteomics-based research projects by identifying proteins separated and
Publikováno v:
Journal of Biological Chemistry. 274:4053-4058
Endothelins are peptide hormones with a potent vasoconstrictor activity that are also known to function as intercellular signaling molecules. The final step in the biosynthesis of endothelins is the proteolytic processing of precursor peptides by end
Publikováno v:
Analytical Biochemistry. 262:99-109
To minimize low-quantity sample handling for protein sequencing and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry, a system consisting of an HPLC interfaced to an automated blotting device was used for off-line sample collecti
Autor:
Nicole M. Horne, Joseph A. Loo, Patrick I. McConnell, Tracy I. Stevenson, W. Tom Mueller, David P. Mack, Tod P. Holler, Susan K. Foltin, Craig Banotai
Publikováno v:
Proteins: Structure, Function, and Genetics. 33:28-37
Mass spectrometry (MS) with electrospray ionization (ESI) has shown utility for studying noncovalent protein complexes, as it offers advantages in sensitivity, speed, and mass accuracy. The stoichiometry of the binding partners can be easily deduced
Autor:
Stephen A. Martin, Wade M. Hines, Dale H. Patterson, Rachel R. Ogorzalek Loo, Tracy I. Stevenson, John M. Peltier, Joseph A. Loo, Charles Mitchell, Peter Juhasz, Philip C. Andrews
Publikováno v:
Electrophoresis. 18:382-390
Matrix-assisted laser desorption ionization (MALDI) mass spectra have been obtained directly from thin-layer isoelectric focusing (IEF) gels with as little as 700 femtomoles of alpha- and beta-chain bovine hemoglobin and bovine carbonic anhydrase, an
Proteomic analysis of hyperdynamic mouse hearts with enhanced sarcoplasmic reticulum calcium cycling
Autor:
Tracy I. Stevenson, Greg W. Kilby, Guoxiang Chu, Jaclyn P. Kerr, Evangelia G. Kranias, John E. Maggio, Meilan Shen, Gregory F. Egnaczyk, Bryan Mitton, Stephen T. Rapundalo, Jenny A. Vazquez, Jerry Vockley
Publikováno v:
The FASEB Journal. 18:1725-1727
Depressed sarcoplasmic reticulum (SR) Ca-cycling is a hallmark of human and experimental heart failure. Strategies to improve this impairment by either increasing SERCA2a levels or decreasing phospholamban (PLN) activity have been suggested as promis
ChemInform Abstract: Application of Mass Spectrometry for Target Identification and Characterization
Publikováno v:
ChemInform. 30
Mass spectrometry-based methodologies span the vast expanse of drug discovery. Both electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI) support proteomics-based research projects by identifying proteins separated and