Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Tracy Guo"'
Autor:
Mei Hua Gao, Dimosthenis Giamouridis, N. Chin Lai, Tracy Guo, Bing Xia, Young Chul Kim, Viet Anh Nguyen Huu, Dorota Skowronska-Krawczyk, Louise Lantier, Raag Bhargava, H. Kirk Hammond
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 220-233 (2020)
Type 1 diabetes affects 20 million patients worldwide. Insulin is the primary and commonly the sole therapy for type 1 diabetes. However, only a minority of patients attain the targeted glucose control and reduced adverse events. We tested urocortin
Externí odkaz:
https://doaj.org/article/828e78bc7b3643b49492393e8da28c44
Autor:
Dimosthenis Giamouridis, BS, MS, Mei Hua Gao, PhD, N. Chin Lai, PhD, Zhen Tan, PhD, Young Chul Kim, PhD, Tracy Guo, BS, Atsushi Miyanohara, PhD, W. Matthijs Blankesteijn, PhD, Erik Biessen, PhD, H. Kirk Hammond, MD
Publikováno v:
JACC: Basic to Translational Science, Vol 3, Iss 2, Pp 249-264 (2018)
Summary: UCn2 and UCn3 peptides have recently been infused to treat patients with heart failure (HF) but are limited by their short half-lives. A 1-time intravenous injection of virus vectors encoding UCn2 or UCn3 provided sustained increases in plas
Externí odkaz:
https://doaj.org/article/7f669bc55c904d3d97cf15fd9a30d1e9
Autor:
Mei Hua Gao, PhD, N. Chin Lai, PhD, Dimosthenis Giamouridis, MSc, Young Chul Kim, PhD, Zhen Tan, PhD, Tracy Guo, BS, Wolfgang H. Dillmann, MD, Jorge Suarez, PhD, H. Kirk Hammond, MD
Publikováno v:
JACC: Basic to Translational Science, Vol 1, Iss 7, Pp 617-629 (2016)
Transgenic mice with cardiac-directed C1C2, a fusion protein of the intracellular C1 and C2 segments of adenylyl cyclase type 6, had normal left ventricular (LV) function, but diminished cAMP generation. Cardiac myocytes from C1C2 mice showed increas
Externí odkaz:
https://doaj.org/article/c3d4b2955ed24706befb04be3dee1927
Autor:
Young Chul Kim, Agnieszka D Truax, Dimosthenis Giamouridis, N Chin Lai, Tracy Guo, H Kirk Hammond, Mei Hua Gao
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0224428 (2019)
IntroductionUrocortin 2 (Ucn2) is a 38-amino acid peptide of the corticotropin-releasing factor family. Intravenous (IV) delivery of an adeno-associated virus vector serotype 8 encoding Ucn2 (AAV8.Ucn2) increases insulin sensitivity and glucose dispo
Externí odkaz:
https://doaj.org/article/a76d1ce9339e432589e71472f8999c89
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0181282 (2017)
Increased expression of adenylyl cyclase type 6 (AC6) has beneficial effects on the heart through cyclic adenosine monophosphate (cAMP)-dependent and cAMP-independent pathways. We previously generated a catalytically inactive mutant of AC6 (AC6mut) t
Externí odkaz:
https://doaj.org/article/a04ae54f71fd4853b07adb6d4178d6d9
Autor:
Mei Hua Gao, Ngai Chin Lai, Tong Tang, Tracy Guo, Ruoying Tang, Byeong Jo Chun, Hong Wang, Nancy N Dalton, Jorge Suarez, Wolfgang H Dillmann, H Kirk Hammond
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e72151 (2013)
So many clinical trials of positive inotropes have failed, that it is now axiomatic that agents that increase cAMP are deleterious to the failing heart. An alternative strategy is to alter myocardial Ca(2+) handling or myofilament response to Ca(2+)
Externí odkaz:
https://doaj.org/article/76ec15caafda425fa06285823978e134
Autor:
Nassereldin Ibrahim, Darlene Nesbitt, Qian (Tracy) Guo, Janet Lin, Antonet Svircev, Qi Wang, Joel T. Weadge, Hany Anany
Publikováno v:
Viruses, Vol 16, Iss 2, p 257 (2024)
Fire blight, caused by Erwinia amylovora, is a devastating bacterial disease that threatens apple and pear production. It is mainly controlled by using antibiotics, such as streptomycin. Due to development of E. amylovora resistant strains and the ex
Externí odkaz:
https://doaj.org/article/58017c4f2b484afca51d3b9c9816f1b4
Autor:
Mianzhao (Tracy) Guo, Abigail S. Baldridge, Kiarri N. Kershaw, Linda V. Van Horn, Kranti Rumalla, Brooke Bright, Dagan Xavier, Mark D. Huffman
Publikováno v:
Nutrition and Health. 29:309-317
Objective: Consumers in the US make choices within a food supply dominated by processed packaged foods and beverage products. Front-of-package nutrition labels (FOPL) equip consumers to make healthier choices, but further evaluation and regulation re
Autor:
Tyler A. U. Hilsabeck, Ru Liu-Bryan, Tracy Guo, Kenneth A. Wilson, Neelanjan Bose, Daniel Raftery, Jennifer N. Beck, Sven Lang, Kelly Jin, Christopher S. Nelson, Tal Oron, Marshall Stoller, Daniel Promislow, Rachel B. Brem, Robert Terkeltaub, Pankaj Kapahi
Publikováno v:
GeroScience, vol 44, iss 4
GeroScience
GeroScience
Elevated serum urate (hyperuricemia) promotes crystalline monosodium urate tissue deposits and gout, with associated inflammation and increased mortality. To identify modifiers of uric acid pathologies, we performed a fly Genome-Wide Association Stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad4657fbfcc42b6acd5163051fb15ec7
https://escholarship.org/uc/item/20c3d830
https://escholarship.org/uc/item/20c3d830
Autor:
David B. Solit, Niharika B. Mettu, Shannon J. McCall, Mallika Dhawan, Priyanka J. Bobbili, Maral DerSarkissian, Jasmina Ivanova, Bhakti Arondekar, Jane Chang, Alexander Niyazov, Jocelyn Lee, Risha Huq, Michelle Green, Michelle Turski, Aruna Muthukumar, Tracy Guo, Mei Sheng Duh, William K. Oh
Publikováno v:
Cancer Research. 83:930-930
Background: Limited information is available about treatments and clinical outcomes among men with metastatic castration-resistant prostate cancer (mCRPC) whose tumors harbor DNA damage repair (DDR) mutations. Methods: This retrospective chart review