Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Tracy G, Anthony"'
Publikováno v:
Clocks & Sleep, Vol 5, Iss 4, Pp 639-650 (2023)
The circadian clock regulates a variety of biological processes that are normally synchronized with the solar day. Disruption of circadian rhythms is associated with health problems. Understanding the signaling mechanisms that couple cell physiology
Externí odkaz:
https://doaj.org/article/776965c8f16e4b568b2a3785d7c49928
Publikováno v:
Journal of the International Society of Sports Nutrition, Vol 19, Iss 1, Pp 603-622 (2022)
Background Exercise modality differentially alters body composition and physical performance. Metabolic changes underlying these outcomes can be tracked through assessment of circulating metabolites. Here, global responses to an acute bout of aerobic
Externí odkaz:
https://doaj.org/article/fcc2f58994c34563928bb65ee47f595d
Autor:
Ricardo A Cordova, Jagannath Misra, Parth H Amin, Anglea J Klunk, Nur P Damayanti, Kenneth R Carlson, Andrew J Elmendorf, Hyeong-Geug Kim, Emily T Mirek, Bennet D Elzey, Marcus J Miller, X Charlie Dong, Liang Cheng, Tracy G Anthony, Roberto Pili, Ronald C Wek, Kirk A Staschke
Publikováno v:
eLife, Vol 11 (2022)
A stress adaptation pathway termed the integrated stress response has been suggested to be active in many cancers including prostate cancer (PCa). Here, we demonstrate that the eIF2 kinase GCN2 is required for sustained growth in androgen-sensitive a
Externí odkaz:
https://doaj.org/article/0e190e2bb8b949968cf1c2d48ee6413b
Autor:
Wenceslao Martinez, Qian Zhang, Melissa A. Linden, Nate Schacher, Sanna Darvish, Emily T. Mirek, Jordan L. Levy, William O. Jonsson, Tracy G. Anthony, Karyn L. Hamilton
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Dietary interventions such as sulfur amino acid restriction (SAAR) target multiple drivers of aging, and show promise for preventing or delaying the onset of chronic diseases. SAAR promotes metabolic health and longevity in laboratory animals. The ef
Externí odkaz:
https://doaj.org/article/4c6709b31ba84f44ad1529f8042b1171
Autor:
Miriam Ferrer, Tracy G. Anthony, Janelle S. Ayres, Giulia Biffi, Justin C. Brown, Bette J. Caan, Elizabeth M. Cespedes Feliciano, Anthony P. Coll, Richard F. Dunne, Marcus D. Goncalves, Jonas Grethlein, Steven B. Heymsfield, Sheng Hui, Mariam Jamal-Hanjani, Jie Min Lam, David Y. Lewis, David McCandlish, Karen M. Mustian, Stephen O’Rahilly, Norbert Perrimon, Eileen P. White, Tobias Janowitz
Publikováno v:
Cell. 186:1824-1845
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df74b60a74581bc8dfcac2f5b065f22d
https://doi.org/10.1016/j.cell.2023.03.028
https://doi.org/10.1016/j.cell.2023.03.028
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
The athletic horse, despite being over 50% muscle mass, remains understudied with regard to the effects of exercise and training on skeletal muscle metabolism. To begin to address this knowledge gap, we employed an untargeted metabolomics approach to
Externí odkaz:
https://doaj.org/article/fb9226b90e514950b8872c56ace6218e
Publikováno v:
Al-Qadisiyah Journal of Veterinary Medicine Sciences, Vol 16, Iss 2, Pp 162-166 (2017)
Asparaginase (ASNase) treatment results in the synthesis of some factors such as activating-transcription-factor-4 (ATF4). The eIF2-ATF4 pathway is essential for cell survival during amino acid starvation conditions. This requires the eukaryotic-init
Externí odkaz:
https://doaj.org/article/7e0a6050856546a49a2ed92e47edb8b1
Autor:
Rana J. T. Al-Baghdadi, Inna A. Nikonorova, Emily T. Mirek, Yongping Wang, Jinhee Park, William J. Belden, Ronald C. Wek, Tracy G. Anthony
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract The anti-leukemic agent asparaginase activates the integrated stress response (ISR) kinase GCN2 and inhibits signaling via mechanistic target of rapamycin complex 1 (mTORC1). The study objective was to investigate the protective role of acti
Externí odkaz:
https://doaj.org/article/8c386a86451643b7ab9901fa57812237
Autor:
Alex J. Bott, Jianliang Shen, Claudia Tonelli, Le Zhan, Nithya Sivaram, Ya-Ping Jiang, Xufen Yu, Vrushank Bhatt, Eric Chiles, Hua Zhong, Sara Maimouni, Weiwei Dai, Stephani Velasquez, Ji-An Pan, Nathiya Muthalagu, Jennifer Morton, Tracy G. Anthony, Hui Feng, Wouter H. Lamers, Daniel J. Murphy, Jessie Yanxiang Guo, Jian Jin, Howard C. Crawford, Lanjing Zhang, Eileen White, Richard Z. Lin, Xiaoyang Su, David A. Tuveson, Wei-Xing Zong
Publikováno v:
Cell Reports, Vol 29, Iss 5, Pp 1287-1298.e6 (2019)
Summary: Glutamine is thought to play an important role in cancer cells by being deaminated via glutaminolysis to α-ketoglutarate (aKG) to fuel the tricarboxylic acid (TCA) cycle. Supporting this notion, aKG supplementation can restore growth/surviv
Externí odkaz:
https://doaj.org/article/86935149469c4359a0a906c3024b9071
Autor:
Jinhee Park, Qiaoqiao Zhu, Emily Mirek, Li Na, Hamidah Raduwan, Tracy G Anthony, William J Belden
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0223803 (2019)
The circadian clock and aging are intertwined. Disruption to the normal diurnal rhythm accelerates aging and corresponds with telomere shortening. Telomere attrition also correlates with increase cellular senescence and incidence of chronic disease.
Externí odkaz:
https://doaj.org/article/d040fea317564bf9a67df07bf17c18a3