DWI and complex brain network analysis predicts vascular cognitive impairment in spontaneous hypertensive rats undergoing executive function tests

Autor: Xavier eLópez-Gil, Ivan eAmat-Roldan, Raúl eTudela, Anna eCastañé, Alberto ePrats-Galino, Anna M Planas, Tracy D Farr, Guadalupe eSoria

Publikováno v: Frontiers in Aging Neuroscience, Vol 6 (2014)

The identification of biomarkers of vascular cognitive impairment is urgent for its early diagnosis. The aim of this study was to detect and monitor changes in brain structure and connectivity, and to correlate them with the decline in executive func

Externí odkaz: https://doaj.org/article/9048307c0e7141b0be8662ed71cd6843

A pilot of the feasibility and usefulness of an aged obese model for use in stroke research [version 1; peer review: 2 approved]

Autor: Annastazia E. Learoyd, Ryan Calmus, Chelsea N. Cunningham, Tim J. England, Tracy D. Farr, Kevin C.F. Fone, David A. Kendall, Saoirse E. O’Sullivan, Rebecca C. Trueman

Publikováno v: Wellcome Open Research, Vol 6 (2021)

Background: Animal models of stroke have been criticised as having poor predictive validity, lacking risk factors prevalent in an aging population. This pilot study examined the development of comorbidities in a combined aged and high-fat diet model,

Externí odkaz: https://doaj.org/article/6d17c5da6d754bc2a211303e3f26d30a

Glyceryl trinitrate for the treatment of ischaemic stroke: Determining efficacy in rodent and ovine species for enhanced clinical translation

Autor: Ingo Schiessl, Anna V. Leonard, Stuart M. Allan, Philip M.W. Bath, Tracy D. Farr, Renée J. Turner, Annastazia E. Learoyd, Annabel J Sorby-Adams, Fiona Burrows, Rebecca C. Trueman

Publikováno v: Sorby-Adams, A J, Learoyd, A E, Bath, P M, Burrows, F, Farr, T D, Leonard, A V, Schiessl, I, Allan, S M, Turner, R J & Trueman, R C 2021, ' Glyceryl trinitrate for the treatment of ischaemic stroke: Determining efficacy in rodent and ovine species for enhanced clinical translation ', Journal of Cerebral Blood Flow & Metabolism . https://doi.org/10.1177/0271678X211018901
Journal of Cerebral Blood Flow & Metabolism

Hypertension is a leading risk factor for death and dependency after ischaemic stroke. However, administering anti-hypertensive medications post-stroke remains contentious with concerns regarding deleterious effects on cerebral blood flow and infarct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f03f6fcfd3df6701ad442d14e5621f5
https://doi.org/10.1177/0271678x211018901

Prediction of Stroke Outcome in Mice Based on Non-Invasive MRI and Behavioral Testing

Autor: Felix Knab, Stefan Paul Koch, Sebastian Major, Tracy D. Farr, Susanne Mueller, Philipp Euskirchen, Moritz Eggers, Melanie T.C. Kuffner, Josefine Walter, Daniel Berchtold, Samuel Knauss, Jens P. Dreier, Andreas Meisel, Matthias Endres, Ulrich Dirnagl, Nikolaus Wenger, Christian J. Hoffmann, Philipp Boehm-Sturm, Christoph Harms

BackgroundPrediction of post-stroke outcome using the degree of subacute deficit or magnetic resonance imaging is well studied in humans. While mice are frequently used animals in preclinical stroke research, systematic analysis of outcome predictors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a042de7a1d1d53688f621b3ded457e4
https://doi.org/10.1101/2022.05.13.491869

17β-Estradiol treatment following permanent focal ischemia does not influence recovery of sensorimotor function

Autor: Tracy D. Farr, Hilary V.O. Carswell, Lindsay Gallagher, Barrie Condon, Andrew J. Fagan, Jim Mullin, I. Mhairi Macrae

Publikováno v: Neurobiology of Disease, Vol 23, Iss 3, Pp 552-562 (2006)

The development of therapy to aid poststroke recovery is essential. The female hormone 17β-estradiol has been shown to promote synaptogenesis; the purpose of this study was to attempt to harness these mechanisms to promote repair and recovery in the

Externí odkaz: https://doaj.org/article/54aec265c5214b8cbda086947b8f3e7f