Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Tracy C. Kuo"'
Autor:
Tracy C. Kuo, Amy Chen, Ons Harrabi, Jonathan T. Sockolosky, Anli Zhang, Emma Sangalang, Laura V. Doyle, Steven E. Kauder, Danielle Fontaine, Sangeetha Bollini, Bora Han, Yang-Xin Fu, Janet Sim, Jaume Pons, Hong I. Wan
Publikováno v:
Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-19 (2020)
Abstract Background Signal regulatory protein α (SIRPα) is a myeloid-lineage inhibitory receptor that restricts innate immunity through engagement of its cell surface ligand CD47. Blockade of the CD47–SIRPα interaction synergizes with tumor-spec
Externí odkaz:
https://doaj.org/article/aafee68f22694b6fb3c27f80eac48cb0
Autor:
Barbra J. Sasu, Javier Chaparro-Riggers, Pavel Strop, Arvind Rajpal, David Shelton, Jeffrey L. Wolf, Thomas G. Martin, Bernard Buetow, Ingrid Pardo, Michael Mirsky, Bora Han, Bing Kuang, Allison G. Chunyk, Kevin C. Lindquist, Yik Andy Yeung, Thomas J. Van Blarcom, Sherman M. Chin, Russell G. Dushin, Marjorie Bateman, Santiago Farias, Kathy Delaria, Wei Chen, Edward Pascua, Cris Kamperschroer, Laura Aschenbrenner, Tao Geng, Amy Chen, Yi Zhang, Tracy C. Kuo, Siler H. Panowski
BCMA bispecific is highly active in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::748b3e6c190c08ac317b01e7ce3f2069
https://doi.org/10.1158/1535-7163.22510278
https://doi.org/10.1158/1535-7163.22510278
Autor:
Barbra J. Sasu, Javier Chaparro-Riggers, Pavel Strop, Arvind Rajpal, David Shelton, Jeffrey L. Wolf, Thomas G. Martin, Bernard Buetow, Ingrid Pardo, Michael Mirsky, Bora Han, Bing Kuang, Allison G. Chunyk, Kevin C. Lindquist, Yik Andy Yeung, Thomas J. Van Blarcom, Sherman M. Chin, Russell G. Dushin, Marjorie Bateman, Santiago Farias, Kathy Delaria, Wei Chen, Edward Pascua, Cris Kamperschroer, Laura Aschenbrenner, Tao Geng, Amy Chen, Yi Zhang, Tracy C. Kuo, Siler H. Panowski
Tables show PK kinetics, plasma cell numbers, and patient data. Methods include all supplemental methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f21b0175c33170d2642c58ea1c4072b
https://doi.org/10.1158/1535-7163.22510263
https://doi.org/10.1158/1535-7163.22510263
Autor:
Barbra J. Sasu, Javier Chaparro-Riggers, Pavel Strop, Arvind Rajpal, David Shelton, Jeffrey L. Wolf, Thomas G. Martin, Bernard Buetow, Ingrid Pardo, Michael Mirsky, Bora Han, Bing Kuang, Allison G. Chunyk, Kevin C. Lindquist, Yik Andy Yeung, Thomas J. Van Blarcom, Sherman M. Chin, Russell G. Dushin, Marjorie Bateman, Santiago Farias, Kathy Delaria, Wei Chen, Edward Pascua, Cris Kamperschroer, Laura Aschenbrenner, Tao Geng, Amy Chen, Yi Zhang, Tracy C. Kuo, Siler H. Panowski
The restricted expression pattern of B-cell maturation antigen (BCMA) makes it an ideal tumor-associated antigen (TAA) for the treatment of myeloma. BCMA has been targeted by both CD3 bispecific antibody and antibody–drug conjugate (ADC) modalities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e53d5a22469996870b78467034a668
https://doi.org/10.1158/1535-7163.c.6539562.v1
https://doi.org/10.1158/1535-7163.c.6539562.v1
Autor:
Steven E Kauder, Tracy C Kuo, Ons Harrabi, Amy Chen, Emma Sangalang, Laura Doyle, Sony S Rocha, Sangeetha Bollini, Bora Han, Janet Sim, Jaume Pons, Hong I Wan
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0201832 (2018)
CD47 is a widely expressed cell surface protein that functions as an immune checkpoint in cancer. When expressed by tumor cells, CD47 can bind SIRPα on myeloid cells, leading to suppression of tumor cell phagocytosis and other innate immune function
Externí odkaz:
https://doaj.org/article/3ebc34039c37468dbf22b9ca99bbcb93
Autor:
Hyun Cheol Chung, Jeeyun Lee, Tracy C. Kuo, Won Seog Kim, Feng Jin, Sophia Randolph, Nehal Lakhani, Yung-Jue Bang, Rafael Santana-Davila, Philip Fanning, Wells A. Messersmith, Pierre Squifflet, Jaume Pons, Justin F. Gainor, Hong I. Wan, Keun-Wook Lee, Laura Q.M. Chow, F.S. Hodi, Patricia LoRusso
Publikováno v:
The Lancet Oncology. 22:1740-1751
Summary Background Both innate and adaptive immune responses are important components of anticancer immunity. The CD47–SIRPα interaction could represent an important pathway used by tumour cells to evade immune surveillance. We aimed to evaluate t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4876fd9854262587a521d889b5fcb60f
https://doi.org/10.1016/s1470-2045(21)00584-2
https://doi.org/10.1016/s1470-2045(21)00584-2
Autor:
Johanna Theruvath, Marie Menard, Benjamin A. H. Smith, Miles H. Linde, Garry L. Coles, Guillermo Nicolas Dalton, Wei Wu, Louise Kiru, Alberto Delaidelli, Elena Sotillo, John L. Silberstein, Anna C. Geraghty, Allison Banuelos, Molly Thomas Radosevich, Shaurya Dhingra, Sabine Heitzeneder, Aidan Tousley, John Lattin, Peng Xu, Jing Huang, Nicole Nasholm, Andy He, Tracy C. Kuo, Emma R. B. Sangalang, Jaume Pons, Amira Barkal, Rachel E. Brewer, Kristopher D. Marjon, Jose G. Vilches-Moure, Payton L. Marshall, Ricardo Fernandes, Michelle Monje, Jennifer R. Cochran, Poul H. Sorensen, Heike E. Daldrup-Link, Irving L. Weissman, Julien Sage, Ravindra Majeti, Carolyn R. Bertozzi, William A. Weiss, Crystal L. Mackall, Robbie G. Majzner
Publikováno v:
Nature medicine, vol 28, iss 2
Nat Med
Nat Med
The disialoganglioside GD2 is overexpressed on several solid tumors, and monoclonal antibodies targeting GD2 have substantially improved outcomes for children with high-risk neuroblastoma. However, approximately 40% of patients with neuroblastoma sti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aad3910b686c28eafa24813f728551c
https://escholarship.org/uc/item/5nz6n240
https://escholarship.org/uc/item/5nz6n240
Autor:
Chen Amy Shaw-Ru, Anup Madan, Janet Sim, Ons Harrabi, Tracy C. Kuo, Hong Wan, Ardian S Wibowo, Shelley Izquierdo, Emma Sangalang, Darlene Pedersen, Josh Carter, Steven E. Kauder, Jonathan T. Sockolosky, Jaume Pons, Harriman William Don, Laura Doyle
Publikováno v:
mAbs
Targeting the CD47-signal-regulatory protein α (SIRPα) pathway represents a novel therapeutic approach to enhance anti-cancer immunity by promoting both innate and adaptive immune responses. Unlike CD47, which is expressed ubiquitously, SIRPα expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b6e62d7e10586ce646d15c3a63cebd
http://europepmc.org/articles/PMC6748616
http://europepmc.org/articles/PMC6748616
Autor:
Danielle Fontaine, Emma Sangalang, Amy Y. Chen, Laura V. Doyle, Ons Harrabi, Tracy C. Kuo, Bradshaw Curt W, Hong Wan, Jaume Pons, Janet Sim, Bora Han
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Toll-like receptor (TLR) pathways play a crucial role in mounting potent innate immune responses against invading pathogens, as well as the subsequent engagement of adaptive immunity. Innate immune activation via the TLR9 pathway has poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df52fdb67dd48c56807f1bf94c7b774d
https://doaj.org/article/73729fd479f24e73bf97b54656bdd8b0
https://doaj.org/article/73729fd479f24e73bf97b54656bdd8b0
Autor:
Danielle Fontaine, Bora Han, Laura V. Doyle, Amy Y. Chen, Ons Harrabi, Hong I. Wan, Emma Sangalang, Janet Sim, Min Li, Jaume Pons, Tracy C. Kuo
Publikováno v:
Cancer Research. 81:1721-1721
Novel therapies capable of engaging both innate and adaptive immune responses may engender durable anti-tumor immunity. Activation of toll-like receptor 9 (TLR9) by unmethylated oligonucleotides promotes innate inflammatory responses and the inductio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18a284770f7c597de10a46d25480b91e
https://doi.org/10.1158/1538-7445.am2021-1721
https://doi.org/10.1158/1538-7445.am2021-1721