Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Tracy Blunt"'
Autor:
Heather Beamish, P. A. Jeggo, Tracy Blunt, Boris Kysela, Anne Priestley, Enriqueta Riballo, R. Jessberger
DNA-PKcs, the catalytic subunit of DNA-dependent protein kinase (DNA-PK), has a phosphoinositol 3-kinase (PI 3-K) domain close to its C-terminus. Cell lines derived from the SCID mouse have been utilised as a model DNA-PKcs-defective system. The SCID
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8087ed65820fb4d4db8f7ec09333168
http://doc.rero.ch/record/304425/files/gkd266.pdf
http://doc.rero.ch/record/304425/files/gkd266.pdf
Autor:
B. K. Singleton, Maria C. Muhlmann-Diaz, Tracy Blunt, Graeme C. M. Smith, Stephen P. Jackson, Anne Priestley, P. A. Jeggo, Leonard C. Schalkwyk, Guillermo E. Taccioli, A. G. Amatucci, Joel S. Bedford, David A. Gell, Heather Beamish
Publikováno v:
Nucleic Acids Research. 26:1965-1973
The catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs) is a member of a sub-family of phosphatidylinositol (PI) 3-kinases termed PIK-related kinases. A distinguishing feature of this sub-family is the presence of a conserved C-terminal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5900e08c19c3005f4491f00bcdee74e
https://doi.org/10.1093/nar/26.8.1965
https://doi.org/10.1093/nar/26.8.1965
Publikováno v:
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 351:173-179
DNA-dependent protein kinase is a nuclear serine/threonine kinase whose catalytic properties are expressed only when the enzyme is bound to DNA ends or other discontinuities in the DNA. DNA-PK comprises two components: one mediates binding to DNA and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb371f9890137e60743d9881ed4bee63
https://doi.org/10.1098/rstb.1996.0014
https://doi.org/10.1098/rstb.1996.0014
Autor:
A.J Varghese, Nicholas J. Finnie, Frederick W. Alt, Tracy Blunt, Penny A Jeggo, Graeme C. M. Smith, Guillermo E. Taccioli, Jocelyne Demengeot, Ryushin Mizuta, Tanya M. Gottlieb, Stephen P. Jackson
Publikováno v:
Cell. 80(5):813-823
Murine cells homozygous for the severe combined immune deficiency mutation ( scid ) and V3 mutant hamster cells fall into the same complementation group and show similar defects in V(D)J recombination and DNA double-stranded break repair. Here we sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6beaf96c2e8f30f24b3092d48c8336c9
Publikováno v:
Vox Sanguinis. 67:397-401
We have studied the RH genes in donors with the RhD-negative haplotype dCes. In contrast to the usual arrangement of genes in RhD-negative individuals, where the lack of antigen expression is due to deletion of the entire RHD gene, we find that the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b143c1269943e042e5e59399b74b5d
https://doi.org/10.1111/j.1423-0410.1994.tb01280.x
https://doi.org/10.1111/j.1423-0410.1994.tb01280.x
Autor:
Stephen P. Jackson, H. Steingrimsdottir, Tracy Blunt, David A. Gell, Anne Priestley, B. K. Singleton, Alan R. Lehmann, P. A. Jeggo
Publikováno v:
Europe PubMed Central
The gene product defective in radiosensitive CHO mutants belonging to ionizing radiation complementation group 5, which includes the extensively studied xrs mutants, has recently been identified as Ku80, a subunit of the Ku protein and a component of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b9480f77e542ccf271ca66b2922447
https://pubmed.ncbi.nlm.nih.gov/9032253
https://pubmed.ncbi.nlm.nih.gov/9032253
Autor:
Stephen P. Jackson, Erwin Schurr, Majid Hafezparast, Jacqueline K. White, Penny A. Jeggo, Alan R. Lehmann, Jing Liu, Guillermo E. Taccioli, Frederick W. Alt, Charlotte C. Cole, Trevor J. McMillan, Anne Priestley, Tracy Blunt
Publikováno v:
Genomics. 30(2)
The Chinese hamster ovary xrs mutants are sensitive to ionizing radiation, defective in DNA double-strand break rejoining, and unable to carry out V(D)J recombination effectively. Recently, the gene defective in these mutants, XRCC5, has been shown t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c19cbd297fcb01bd3ebcb6ca13b6aa3f
https://pubmed.ncbi.nlm.nih.gov/8586433
https://pubmed.ncbi.nlm.nih.gov/8586433
DNA-dependent protein kinase (DNA-PK) is a nuclear serine/threonine protein kinase composed of a catalytic subunit called p350 and a DNA binding component termed Ku. Ku consists of two tightly associated polypeptides of approximately 70 kDa and 80 kD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84365b2022fcca85e0ed5fdca41605eb
https://europepmc.org/articles/PMC42870/
https://europepmc.org/articles/PMC42870/
Autor:
Anne Priestley, Stephen P. Jackson, Tracy Blunt, Ryushin Mizuta, Tanya M. Gottlieb, Frederick W. Alt, Guillermo E. Taccioli, Jocelyne Demengeot, Penny A. Jeggo, Alan R. Lehmann
Publikováno v:
Science (New York, N.Y.). 265(5177)
The radiosensitive mutant xrs-6, derived from Chinese hamster ovary cells, is defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. The human XRCC5 DNA repair gene, which complements this mutant, is shown here thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231e8b8575382bf674f9748ddc88e6d5
https://pubmed.ncbi.nlm.nih.gov/8073286
https://pubmed.ncbi.nlm.nih.gov/8073286