Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Tracy Bayliss"'
Autor:
Vitor Mendes, Simon R. Green, Joanna C. Evans, Jeannine Hess, Michal Blaszczyk, Christina Spry, Owain Bryant, James Cory-Wright, Daniel S-H. Chan, Pedro H. M. Torres, Zhe Wang, Navid Nahiyaan, Sandra O’Neill, Sebastian Damerow, John Post, Tracy Bayliss, Sasha L. Lynch, Anthony G. Coyne, Peter C. Ray, Chris Abell, Kyu Y. Rhee, Helena I. M. Boshoff, Clifton E. Barry, Valerie Mizrahi, Paul G. Wyatt, Tom L. Blundell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The bifunctional enzyme CoaBC catalyses the second and third step in the Coenzyme A (CoA) biosynthesis pathway and is of interest as a M. tuberculosis drug target. Here, the authors present the full-length crystal structure of Mycobacterium smegmatis
Externí odkaz:
https://doaj.org/article/dfbd7ac1fa2f42d49910fcdc7940c42e
Autor:
Kirsteen I. Buchanan, Clifton E. Barry, Simon Green, Gregory S. Basarab, Qin Su, Charles J. Eyermann, Curtis A. Engelhart, Anuradha Kumar, Paul D. van Helden, Frederick A. Sirgel, Paul G. Wyatt, Nina Lawrence, Sandeep R. Ghorpade, Dirk Schnappinger, Dale Taylor, Sandile B. Simelane, Helena I. Boshoff, Christel Brunschwig, Vinayak Singh, Kelly Chibale, Peter C. Ray, Tracy Bayliss, Candice Soares de Melo, Alissa Myrick, Tanya Parish, Timothy G. Myers
Publikováno v:
Journal of Medicinal Chemistry
Phenotypic screening of a Medicines for Malaria Venture compound library against Mycobacterium tuberculosis (Mtb) identified a cluster of pan-active 2-pyrazolylpyrimidinones. The biology triage of these actives using various tool strains of Mtb sugge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff5eafa1e33ac7c64b2164da5d55d9f9
https://pubmed.ncbi.nlm.nih.gov/33395287
https://pubmed.ncbi.nlm.nih.gov/33395287
Autor:
Clifton E. Barry, Paul G. Wyatt, Sasha L. Lynch, Pedro Henrique Monteiro Torres, Daniel Shiu-Hin Chan, Simon Green, Helena I. Boshoff, Joanna C. Evans, Vitor Mendes, Kyu Y. Rhee, James Cory-Wright, Michal Blaszczyk, Peter C. Ray, Valerie Mizrahi, Sebastian Damerow, Navid Nahiyaan, Anthony G. Coyne, John Post, Tom L. Blundell, Tracy Bayliss, Sandra O’Neill, Chris Abell, Jeannine Hess, Christina Spry, Zhe Wang, Owain J. Bryant
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Coenzyme A (CoA) is a fundamental co-factor for all life, involved in numerous metabolic pathways and cellular processes, and its biosynthetic pathway has raised substantial interest as a drug target against multiple pathogens including Mycobacterium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e93480516255c2e8d7aeba39be349059
http://europepmc.org/articles/PMC7794376
http://europepmc.org/articles/PMC7794376
Autor:
Helena I. Boshoff, Yumi Park, Thomas R. Ioerger, Clifton E. Barry, Laura E. Via, Michael Goodwin, Simon Green, Paul G. Wyatt, Sangmi Oh, Tracy Bayliss, Surendranadha Reddy Jonnala, Peter C. Ray, Julia M. Fisher, Yong Mo Ahn
Publikováno v:
Antimicrobial agents and chemotherapy. 63(10)
Mechanisms of magnesium homeostasis in Mycobacterium tuberculosis are poorly understood. Here, we describe the characterization of a pyrimidinetrione amide scaffold that disrupts magnesium homeostasis in the pathogen by direct binding to the CorA Mg(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd4214f8a3885afb190c73901daff33
https://pubmed.ncbi.nlm.nih.gov/31383669
https://pubmed.ncbi.nlm.nih.gov/31383669
Autor:
Lucy Ellis, Yumi Park, Ola Epemolu, Paul G. Wyatt, Stefano Donini, Laura E. Via, Carolyn Selenski, Matthew Axtman, Thomas R. Ioerger, Menico Rizzi, Tom L. Blundell, Nian Zhou, Simon Green, Olalla Sanz, Maria Osuna-Cabello, David B. Ascher, Helena I. Boshoff, Laste Stojanovski, Travis Hartman, Dale J. Kempf, Clifton E. Barry, Joël Lelièvre, Tracy Bayliss, Zhe Wang, Fred Simeons, Claire J. MacKenzie, Hannah Pflaumer, Valerie Mizrahi, Fabio Zuccotto, James C. Sacchettini, Gracia Santos Diaz, Véronique Dartois, Angela Pacitto, Susan Davis, Kyu Y. Rhee, Laura A. T. Cleghorn, Margaret Huggett, Matthew D. Kurnick, Dinakaran Murugesan, Penelope A. Turner, Kriti Arora, Gerard Drewes, Lluis Ballell, Markus Bösche, Gail M. Freiberg, Kevin D. Read, Surendranadha Reddy Jonnala, Kirsteen I. Buchanan, Maria Jose Lafuente-Monasterio, María José Rebollo-López, Sonja Ghidelli-Disse, Peter C. Ray, Alasdair Smith, Myron Srikumaran, Ardala Breda
Publikováno v:
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
A potent, noncytotoxic indazole sulfonamide was identified by high-throughput screening of >100,000 synthetic compounds for activity against Mycobacterium tuberculosis (Mtb). This noncytotoxic compound did not directly inhibit cell wall biogenesis bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::896be08dd9046b3b0b9f82d81de880f5
https://doi.org/10.1021/acsinfecdis.6b00103
https://doi.org/10.1021/acsinfecdis.6b00103
Autor:
Tracy, Bayliss, David A, Robinson, Victoria C, Smith, Stephen, Brand, Stuart P, McElroy, Leah S, Torrie, Chido, Mpamhanga, Suzanne, Norval, Laste, Stojanovski, Ruth, Brenk, Julie A, Frearson, Kevin D, Read, Ian H, Gilbert, Paul G, Wyatt
Publikováno v:
Journal of Medicinal Chemistry
N-Myristoyltransferase (NMT) represents a promising drug target within the parasitic protozoa Trypanosoma brucei (T. brucei), the causative agent for human African trypanosomiasis (HAT) or sleeping sickness. We have previously validated T. brucei NMT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::47d2419ec955be14a52f52fa49ca245b
https://pubmed.ncbi.nlm.nih.gov/29125744
https://pubmed.ncbi.nlm.nih.gov/29125744
Autor:
Kriti Arora, Clifton E. Barry, Jinwoo Lee, Patricia S. Tsang, Claire J. MacKenzie, Stephanie S. Dawes, Paul G. Wyatt, Tracy Bayliss, Laura A. T. Cleghorn, Eugene Uh, Bernardo Ochoa-Montaño, Peter C. Ray, Tom L. Blundell, Helena I. Boshoff, Valerie Mizrahi
Publikováno v:
Antimicrobial Agents and Chemotherapy. 61
Volume 58, no. 11, p. 6962–6965, 2014, [https://doi.org/10.1128/AAC.03486-14][1]. Page 6963, left column, second paragraph: the following text in lines 5 to 10 should be deleted. “We deleted this oxidase in H37Rv by replacing a 221-bp MluI fragme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83f8d3d47d145fa69f69d374a7347223
https://doi.org/10.1128/aac.01429-17
https://doi.org/10.1128/aac.01429-17
Autor:
Patricia S. Tsang, Tracy Bayliss, Clifton E. Barry, Peter C. Ray, Claire J. MacKenzie, Valerie Mizrahi, Jinwoo Lee, Helena I. Boshoff, Eugene Uh, Bernardo Ochoa-Montaño, Stephanie S. Dawes, Kriti Arora, Paul G. Wyatt, Laura A. T. Cleghorn, Tom L. Blundell
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:6962-6965
We report here a series of five chemically diverse scaffolds that have in vitro activities on replicating and hypoxic nonreplicating bacilli by targeting the respiratory bc 1 complex in Mycobacterium tuberculosis in a strain-dependent manner. Deletio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8873ff9a62be7411ce9549af65eda550
https://doi.org/10.1128/aac.03486-14
https://doi.org/10.1128/aac.03486-14
Autor:
David A. Robinson, Suzanne Norval, Irene Hallyburton, Stephen Brand, Ian H. Gilbert, Kevin D. Read, Tracy Bayliss, Michael A. J. Ferguson, Justin R. Harrison, Leah S. Torrie, Daniel Spinks, Laste Stojanovski, Neil R. Norcross, Ruth Brenk, Victoria Smith, Stuart P. McElroy, Julie A. Frearson, Laura A. T. Cleghorn, Alan H. Fairlamb, Paul G. Wyatt
Publikováno v:
Journal of Medicinal Chemistry
N-Myristoyltransferase (NMT) represents a promising drug target for human African trypanosomiasis (HAT), which is caused by the parasitic protozoa Trypanosoma brucei. We report the optimization of a high throughput screening hit (1) to give a lead mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f051b840d7b9653c4810af92787d47
https://doi.org/10.1021/jm201091t
https://doi.org/10.1021/jm201091t