Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Tracy A. Lane"'
Accurately quantifying gene and isoform expression changes is essential to understanding cell functions, differentiation and disease. Therefore, a crucial requirement of RNA sequencing is identifying differential expression. The recent development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::382e44a4deb33d81c13b2e8cd47c07bf
https://ora.ox.ac.uk/objects/uuid:8fe6ad42-119d-49a5-a59d-15acab194b71
https://ora.ox.ac.uk/objects/uuid:8fe6ad42-119d-49a5-a59d-15acab194b71
Autor:
Yair David Joseph Prawer, Adrien Leger, Michael B. Clark, Paul Harrison, Josie Gleeson, Tracy A. Lane, Wilfried Haerty
Publikováno v:
Nucleic Acids Research. 50:e19-e19
Accurately quantifying gene and isoform expression changes is essential to understanding cell functions, differentiation and disease. Sequencing full-length native RNAs using long-read direct RNA sequencing (DRS) has the potential to overcome many li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c569933913bae45a1c506ecb8455f66
https://doi.org/10.1093/nar/gkab1129
https://doi.org/10.1093/nar/gkab1129
Autor:
David M. Bannerman, Tracy A. Lane, Elizabeth M. Tunbridge, Paul Harrison, Trevor Sharp, James N.C. Kew, Thomas Boerner
Publikováno v:
BMC Neuroscience
Background Group II metabotropic glutamate receptors (mGlu2 and mGlu3, encoded by Grm2 and Grm3) have been the focus of attention as treatment targets for a number of psychiatric conditions. Double knockout mice lacking mGlu2 and mGlu3 (mGlu2/3−/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d257b2edc58ea6d80e93c4ac0717dcc2
https://ora.ox.ac.uk/objects/uuid:fe2950bd-cb73-4bb4-be4f-279ecabba33b
https://ora.ox.ac.uk/objects/uuid:fe2950bd-cb73-4bb4-be4f-279ecabba33b
Autor:
Paul Harrison, Kew Jnc., Louisa Lyon, Burnet Pwj., David M. Bannerman, B. De Filippis, Rawlins Jnp., Tracy A. Lane, Corrado Corti
Publikováno v:
Neuropsychopharmacology
Group II metabotropic glutamate receptors (mGluR2 and mGluR3, encoded by GRM2 and GRM3) are implicated in hippocampal function and cognition, and in the pathophysiology and treatment of schizophrenia and other psychiatric disorders. However, pharmaco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60def59b499e24e7a0badf1bbac8ebd3
https://doi.org/10.1038/npp.2011.145
https://doi.org/10.1038/npp.2011.145
Catechol-o-methyltransferase (COMT) is important for modulating dopamine levels, prefrontal cortex (PFC) function, and several psychiatric phenotypes. A single COMT mRNA has been described in human brain, which gives rise to membrane-bound (MB)- and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d014b57e66f14d6cc17b988fdc29caed
https://doi.org/10.1002/ajmg.b.30539
https://doi.org/10.1002/ajmg.b.30539
Group II metabotropic glutamate receptors (mGluRs) comprise mGluR2 (mGlu2; encoded by GRM2) and mGluR3 (mGlu3; encoded by GRM3) and modulate glutamate neurotransmission and synaptic plasticity. Here we review the expression and function of mGluR3 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a00431bf015d80ab71ee041cdfe190
https://ora.ox.ac.uk/objects/uuid:20f11280-ea10-4e41-b94e-6295e24a6144
https://ora.ox.ac.uk/objects/uuid:20f11280-ea10-4e41-b94e-6295e24a6144
Autor:
M A Walker, Yoshi Sei, Li Chen, Sharon L. Eastwood, Tracy A. Lane, Joel E. Kleinman, Thomas M. Hyde, Greg C. Bristow, Paul Harrison
Publikováno v:
Brain Research. 1301:197-206
Single nucleotide polymorphisms (SNPs) within the gene encoding the serine/threonine kinase KIS (Kinase Interacting with Stathmin, also known as UHMK1) have recently been associated with schizophrenia. As none of the disease associated SNPs are codin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0537cc7d94f8e5d115f4887c75d87890
https://doi.org/10.1016/j.brainres.2009.08.090
https://doi.org/10.1016/j.brainres.2009.08.090
Publikováno v:
Psychoneuroendocrinology. 60
Purpose Prenatal depression increases risk for a number of adverse offspring outcomes, however the biological mechanisms underlying this association remain unclear. It has been suggested that maternal glucocorticoids may mediate this link, though sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f7d125dcc2adf57eee68fe45295cb8
https://pubmed.ncbi.nlm.nih.gov/26150358
https://pubmed.ncbi.nlm.nih.gov/26150358
Autor:
Helena Cousijn, Joo Heon Shin, Thomas M. Hyde, Paul Harrison, Tracy A. Lane, Daniel R. Weinberger, Joel E. Kleinman, Ran Tao, Freya Edwards, Brady J. Maher, Andrew E. Jaffe, Sharon L. Eastwood, M A Walker, Philip W.J. Burnet
Publikováno v:
JAMA psychiatry. 71(10)
IMPORTANCE: The single-nucleotide polymorphism rs1344706 in the zinc finger protein 804A gene (ZNF804A) shows genome-wide association with schizophrenia and bipolar disorder. Little is known regarding the expression of ZNF804A and the functionality o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a6170fee149f63819801f60f96087f0
http://ora.ox.ac.uk/objects/uuid:e8a6b36d-7e81-4b17-92de-7ead93ba11d6
http://ora.ox.ac.uk/objects/uuid:e8a6b36d-7e81-4b17-92de-7ead93ba11d6
Autor:
David Pritchett, Elizabeth M. Tunbridge, Paul Harrison, David M. Bannerman, Jill F. Betts, Wiebke Nissen, Katharina Stumpenhorst, Karri Lamsa, Trevor Sharp, Judith Schweimer, Philip W.J. Burnet, Tracy A. Lane
Publikováno v:
Neuropharmacology. 62(3)
Genetic mouse models relevant to schizophrenia complement, and have to a large extent supplanted, pharmacological and lesion-based rat models. The main attraction is that they potentially have greater construct validity; however, they share the funda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca670e643f4d8b1933bf50129778757
http://ora.ox.ac.uk/objects/uuid:5c790a81-2156-499e-bcfa-363ae4b10786
http://ora.ox.ac.uk/objects/uuid:5c790a81-2156-499e-bcfa-363ae4b10786