Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Tracy Engles"'
Isolation, Synthesis, and Characterization of Impurities and Degradants from the Clofarabine Process
Publikováno v:
Organic Process Research & Development. 12:1229-1237
The identification of clofarabine process impurities and their subsequent isolation, synthesis, and characterization is described. Two isomeric process impurities resulting from N6-attachment of a fluoroarabinose to clofarabine were found. Clofarabin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::408be24a8609ca3085ecaca142ed57ad
https://doi.org/10.1021/op800182x
https://doi.org/10.1021/op800182x
Publikováno v:
Tetrahedron Letters. 47:4249-4251
Addition of aqueous hydrogen peroxide significantly accelerates the substitution reactions of hydroxide salts with haloarenes bearing electron withdrawing substituents. A similar effect is observed in the reactions of hydroxide salts with halogenated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6547495501abff6e4ec4f59d765ec1e5
https://doi.org/10.1016/j.tetlet.2006.04.020
https://doi.org/10.1016/j.tetlet.2006.04.020
Autor:
Paul Wolstenholme-Hogg, Tracy Engles, William E. Bauta, Bruce Girard Anderson, Dennis Lovett, William R. Cantrell
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 27(8)
Degradation of clofarabine (3) in 0.9% saline solution at 100 degrees C afforded three degradation products which were determined to be formamidopyrimidines 4-6. Compounds 4 and 5 were assigned as C(1') anomers on the basis of one-dimensional and two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9a3d9f0f97628b9430a4aecf025c33
https://pubmed.ncbi.nlm.nih.gov/18696361
https://pubmed.ncbi.nlm.nih.gov/18696361
Publikováno v:
Organic Process Research & Development; Nov2008, Vol. 12 Issue 6, p1229-1237, 9p