Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Tracy, Stromer"'
Autor:
Vaibhav Sidarala, Gemma L. Pearson, Vishal S. Parekh, Benjamin Thompson, Lisa Christen, Morgan A. Gingerich, Jie Zhu, Tracy Stromer, Jianhua Ren, Emma C. Reck, Biaoxin Chai, John A. Corbett, Thomas Mandrup-Poulsen, Leslie S. Satin, Scott A. Soleimanpour
Publikováno v:
JCI Insight, Vol 5, Iss 24 (2020)
Inflammatory damage contributes to β cell failure in type 1 and 2 diabetes (T1D and T2D, respectively). Mitochondria are damaged by inflammatory signaling in β cells, resulting in impaired bioenergetics and initiation of proapoptotic machinery. Hen
Externí odkaz:
https://doaj.org/article/5621b7dc174d44beb66d61a7da10a016
Autor:
Gemma L. Pearson, Emily M. Walker, Nathan Lawlor, Anne Lietzke, Vaibhav Sidarala, Jie Zhu, Tracy Stromer, Emma C. Reck, Jin Li, Aaron Renberg, Kawthar Mohamed, Vishal S. Parekh, Irina X. Zhang, Benjamin Thompson, Deqiang Zhang, Sarah A. Ware, Leena Haataja, Stephen C.J. Parker, Peter Arvan, Lei Yin, Brett A. Kaufman, Leslie S. Satin, Lori Sussel, Michael L. Stitzel, Scott A. Soleimanpour
Mitochondrial dysfunction is a hallmark of metabolic diseases, including diabetes, yet the consequences of mitochondrial damage in metabolic tissues are often unclear. Here, we report that mitochondrial dysfunction engages a retrograde (mitonuclear)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e517b42d9cbfc566e59056e5b624ac9
https://doi.org/10.1101/2022.08.02.502357
https://doi.org/10.1101/2022.08.02.502357
Autor:
Morgan A, Gingerich, Xueying, Liu, Biaoxin, Chai, Gemma L, Pearson, Michael P, Vincent, Tracy, Stromer, Jie, Zhu, Vaibhav, Sidarala, Aaron, Renberg, Debashish, Sahu, Daniel J, Klionsky, Santiago, Schnell, Scott A, Soleimanpour
Publikováno v:
Autophagy
CLEC16A regulates mitochondrial health through mitophagy and is associated with over 20 human diseases. However, the key structural and functional regions of CLEC16A, and their relevance for human disease, remain unknown. Here, we report that a disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3ccd59a485e9fe61f03973cfe036db1f
https://pubmed.ncbi.nlm.nih.gov/35604110
https://pubmed.ncbi.nlm.nih.gov/35604110
Autor:
Morgan A. Gingerich, Xueying Liu, Biaoxin Chai, Gemma L. Pearson, Michael P. Vincent, Tracy Stromer, Jie Zhu, Vaibhav Sidarala, Aaron Renberg, Debashish Sahu, Daniel J. Klionsky, Santiago Schnell, Scott A. Soleimanpour
CLEC16A regulates mitochondrial health through mitophagy and is associated with over 20 human diseases. However, the key structural and functional regions of CLEC16A, and their relevance for human disease, remain unknown. Here, we report that a disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52afa66c37fbd5ed98968fda796e89eb
Autor:
Jie Zhu, Xueying Liu, Gemma L. Pearson, Aaron Renberg, Scott A. Soleimanpour, Vaibhav Sidarala, Debashish Sahu, Morgan A. Gingerich, Daniel J. Klionsky, Biaoxin Chai, Michael S. Vincent, Santiago Schnell, Tracy Stromer
CLEC16A regulates mitochondrial health through mitophagy and is associated with over 20 human diseases. While CLEC16A has ubiquitin ligase activity, the key structural and functional regions of CLEC16A, and their relevance for human disease, remain u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fca2367b58f28836f0dcde599da7b302
https://doi.org/10.1101/2021.09.03.458272
https://doi.org/10.1101/2021.09.03.458272
Autor:
John A. Corbett, Emma C. Reck, Scott A. Soleimanpour, Biaoxin Chai, Morgan A. Gingerich, Benjamin Thompson, Lisa Christen, Thomas Mandrup-Poulsen, Vishal S. Parekh, Gemma L. Pearson, Vaibhav Sidarala, Leslie S. Satin, Jianhua Ren, Jie Zhu, Tracy Stromer
Publikováno v:
JCI Insight
JCI Insight, Vol 5, Iss 24 (2020)
Sidarala, V, Pearson, G L, Parekh, V S, Thompson, B, Christen, L, Gingerich, M A, Zhu, J, Stromer, T, Ren, J, Reck, E C, Chai, B, Corbett, J A, Mandrup-Poulsen, T, Satin, L S & Soleimanpour, S A 2020, ' Mitophagy protects beta cells from inflammatory damage in diabetes ', JCI insight, vol. 5, no. 24, 141138 . https://doi.org/10.1172/jci.insight.141138
JCI Insight, Vol 5, Iss 24 (2020)
Sidarala, V, Pearson, G L, Parekh, V S, Thompson, B, Christen, L, Gingerich, M A, Zhu, J, Stromer, T, Ren, J, Reck, E C, Chai, B, Corbett, J A, Mandrup-Poulsen, T, Satin, L S & Soleimanpour, S A 2020, ' Mitophagy protects beta cells from inflammatory damage in diabetes ', JCI insight, vol. 5, no. 24, 141138 . https://doi.org/10.1172/jci.insight.141138
Inflammatory damage contributes to β-cell failure in type 1 and 2 diabetes (T1D and T2D). Mitochondria are damaged by inflammatory signaling in β-cells, resulting in impaired bioenergetics and initiation of pro-apoptotic machinery. Hence, the ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95489b3a754e5976312f493596ac093
https://doi.org/10.1101/2020.06.07.138917
https://doi.org/10.1101/2020.06.07.138917