Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Tracy, Hussell"'
Autor:
Ahilanandan Dushianthan, Howard W. Clark, David Brealey, Danny Pratt, James B. Fink, Jens Madsen, Helen Moyses, Lewis Matthews, Tracy Hussell, Ratko Djukanovic, Martin Feelisch, Anthony D. Postle, Michael P. W. Grocott
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract SARS-CoV-2 directly targets alveolar epithelial cells and can lead to surfactant deficiency. Early reports suggested surfactant replacement may be effective in improving outcomes. The aim of the study to assess the feasibility and efficacy o
Externí odkaz:
https://doaj.org/article/a77d36c23f7d4e1287d0bc5878c169f2
Autor:
Koji Itakura, Naoya Fujino, Yosuke Kamide, Ikuo Saito, Mitsuhiro Yamada, Koji Okutomo, Yoko Tsukita, Takuya Saito, Tomohiro Ichikawa, Tadahisa Numakura, Yorihiko Kyogoku, Hiroyuki Aizawa, Yoshinao Ono, Shuichiro Matsumoto, Tracy Hussell, Masami Taniguchi, Masakazu Ichinose, Hisatoshi Sugiura
Publikováno v:
Allergology International, Vol 71, Iss 3, Pp 383-394 (2022)
Background: Airway epithelium-derived cytokines are critical to provoke and perpetuate type 2 inflammation in asthma. Yet it is poorly understood how this epithelial cell-driven inflammatory response is negatively regulated. We previously reported th
Externí odkaz:
https://doaj.org/article/940d6e3cedc14ea78ab7602d71eff235
Autor:
Ben Mulhearn, Lysette Marshall, Megan Sutcliffe, Susan K. Hannes, Chamith Fonseka, Tracy Hussell, Soumya Raychaudhuri, Anne Barton, Sebastien Viatte
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundDespite the report of an imbalance between CD4+ T helper (Th) cell subsets in rheumatoid arthritis (RA), patient stratification for precision medicine has been hindered by the discovery of ever more Th cell subsets, as well as contradictory
Externí odkaz:
https://doaj.org/article/90edaa19b76c4d2bbf507c9f97876dc6
Autor:
Daiana Drehmer, João Paulo Mesquita Luiz, Cesar Augusto Speck Hernandez, José Carlos Alves-Filho, Tracy Hussell, Paul Andrew Townsend, Salvador Moncada
Publikováno v:
Redox Biology, Vol 54, Iss , Pp 102350- (2022)
Production of nitric oxide (NO) has been demonstrated in several malignancies, however its role remains not fully understood, specifically in relation to the metabolic and functional implications that it may have on immune cells participating in tumo
Externí odkaz:
https://doaj.org/article/b4f0f96a2a354b458be8337cb813226c
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Natural killer (NK) cells are an important component of the innate immune system, and have a key role in host defense against infection and in tumor surveillance. Tumors and viruses employ remarkably similar strategies to avoid recognition and killin
Externí odkaz:
https://doaj.org/article/5a7face3e69c429fb3b32da23259d9f7
Autor:
Susanne Dechantsreiter, Ashley R. Ambrose, Jonathan D. Worboys, Joey M. E. Lim, Sylvia Liu, Rajesh Shah, M. Angeles Montero, Anne Marie Quinn, Tracy Hussell, Gillian M. Tannahill, Daniel M. Davis
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 4, Pp n/a-n/a (2022)
Abstract The diverse origins, nanometre‐scale and invasive isolation procedures associated with extracellular vesicles (EVs) mean they are usually studied in bulk and disconnected from their parental cell. Here, we used super‐resolution microscop
Externí odkaz:
https://doaj.org/article/b757983969c0432a9dc11231c7a45208
Autor:
Ling-Pei Ho, Liam G Heaney, Ran Wang, Chris Brightling, Joanna Porter, Stefan J Marciniak, Tom Wilkinson, Jane C Davies, Laurence Pearmain, Alex R Horsley, Lorcan P McGarvey, Ratko Djukanović, Nick Schindler, Sean Knight, Miriam Bennett, Rebecca C Robey, Tracy Hussell
Publikováno v:
BMJ Open Respiratory Research, Vol 9, Iss 1 (2022)
Background The COVID-19 pandemic has presented substantial new challenges to clinical and research teams. Our objective was to analyse the experience of investigators and research delivery staff regarding the research response to COVID-19 in order to
Externí odkaz:
https://doaj.org/article/752596b5ea4e496192277c545c4c7e49
Autor:
Julie C. Wilson, David Kealy, Sally R. James, Tobias Plowman, Katherine Newling, Christopher Jagger, Kara Filbey, Elizabeth R. Mann, Joanne E. Konkel, Madhvi Menon, Sean B. Knight, Angela Simpson, Aliya Prihartadi, Greg Forshaw, Neil Todd, David R.A. Yates, John R. Grainger, Tracy Hussell, Paul M. Kaye, Nathalie Signoret, Dimitris Lagos
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103672- (2022)
Summary: Inflammatory cytokines and chemokines (CC) drive COVID-19 pathology. Yet, patients with similar circulating CC levels present with different disease severity. Here, we determined 171 microRNAomes from 58 hospitalized COVID-19 patients (Cohor
Externí odkaz:
https://doaj.org/article/ae60124013314a368798f2b53c4974ad
Autor:
Ahilanandan Dushianthan, Howard Clark, Jens Madsen, Robin Mogg, Lewis Matthews, Lee Berry, Jorge Bernardino de la Serna, James Batchelor, David Brealey, Tracy Hussell, Joanna Porter, Ratko Djukanovic, Martin Feelisch, Anthony Postle, Michael P. W. Grocott
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-3 (2020)
Abstract Objectives SARS-Cov-2 virus preferentially binds to the Angiotensin Converting Enzyme 2 (ACE2) on alveolar epithelial type II cells, initiating an inflammatory response and tissue damage which may impair surfactant synthesis contributing to
Externí odkaz:
https://doaj.org/article/e06ae409470d45d1addb648b7e58875c
Autor:
Elizabeth K. Marsh, Elizabeth C. Prestwich, Lynne Williams, Amber R. Hart, Clare F. Muir, Lisa C. Parker, Marnix R. Jonker, Irene H. Heijink, Wim Timens, Mark Fife, Tracy Hussell, Marc B. Hershenson, J. Kelley Bentley, Shao-Cong Sun, Ben S. Barksby, Lee A. Borthwick, James P. Stewart, Ian Sabroe, David H. Dockrell, Helen M. Marriott
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Exposure to respiratory pathogens is a leading cause of exacerbations of airway diseases such as asthma and chronic obstructive pulmonary disease (COPD). Pellino-1 is an E3 ubiquitin ligase known to regulate virally-induced inflammation. We wished to
Externí odkaz:
https://doaj.org/article/c5942d2d51cf4be9955c03b1925a6bc9