Výsledky vyhledávání - "Tracie DeVries-Seimon"

Induction of Apoptosis Is Driven by Nuclear Retention of Protein Kinase Cδ

Autor: Tracie DeVries-Seimon, Mary E. Reyland, Michael J. Humphries, Angela M. Ohm

Publikováno v: Journal of Biological Chemistry. 282:22307-22314

Protein kinase C delta (PKC delta) mediates apoptosis downstream of many apoptotic stimuli. Because of its ubiquitous expression, tight regulation of the proapoptotic function of PKC delta is critical for cell survival. Full-length PKC delta is found

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::289409ddb6e6d7dd139c6fad9897f85b
https://doi.org/10.1074/jbc.m703661200

Zobrazit plný text záznamu

Free Cholesterol-loaded Macrophages Are an Abundant Source of Tumor Necrosis Factor-α and Interleukin-6

Autor: Yankun Li, Marie-Christine Gerbod-Giannone, Robert F. Schwabe, Richard A. Flavell, Alan R. Tall, David A. Brenner, Ira Tabas, Tracie DeVries-Seimon, Pin Mei Yao, Roger J. Davis

Publikováno v: Journal of Biological Chemistry. 280:21763-21772

Two key features of atherosclerotic plaques that precipitate acute atherothrombotic vascular occlusion (“vulnerable plaques”) are abundant inflammatory mediators and macrophages with excess unesterified, or “free,” cholesterol (FC). Herein we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ceff1964b39702d9d44112fcd05235bb
https://doi.org/10.1074/jbc.m501759200

Zobrazit plný text záznamu

Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor

Autor: Pin Mei Yao, Yibin Wang, Tracie DeVries-Seimon, Elizabeth F. Stone, Richard A. Flavell, Ira Tabas, Yankun Li, Roger J. Davis

Publikováno v: The Journal of Cell Biology
The Journal of cell biology, vol 171, iss 1

Macrophage death in advanced atherosclerosis promotes necrosis and plaque destabilization. A likely cause of macrophage death is accumulation of free cholesterol (FC) in the ER, leading to activation of the unfolded protein response (UPR) and C/EBP h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d971c93665f1e6a8b9a8a7cda31b0863
https://pubmed.ncbi.nlm.nih.gov/16203857

Zobrazit plný text záznamu

Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis

Autor: Yankun, Li, Robert F, Schwabe, Tracie, DeVries-Seimon, Pin Mei, Yao, Marie-Christine, Gerbod-Giannone, Alan R, Tall, Roger J, Davis, Richard, Flavell, David A, Brenner, Ira, Tabas

Publikováno v: The Journal of biological chemistry. 280(23)

Two key features of atherosclerotic plaques that precipitate acute atherothrombotic vascular occlusion ("vulnerable plaques") are abundant inflammatory mediators and macrophages with excess unesterified, or "free," cholesterol (FC). Herein we show th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3a83eed85d248037cfdf25bb7cd7e4e3
https://pubmed.ncbi.nlm.nih.gov/15826936

Zobrazit plný text záznamu

Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions

Autor: Ira Tabas, Domenico Accili, Mollie Ranalletta, Tracie DeVries-Seimon, Seongah Han, Chien-Ping Liang, Carrie L. Welch, Kadesha Collins-Fletcher, Alan R. Tall

Publikováno v: Cell Metabolism. (4):257-266

Insulin resistance in diabetes and metabolic syndrome is thought to increase susceptibility to atherosclerotic cardiovascular disease, but the underlying mechanisms are poorly understood. To evaluate the possibility that decreased insulin signaling i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9da6e68821413aaf98f99aa74e0f363

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání