Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Tracie A. Paine"'
Autor:
Vaughan Schwob, Elise Sai-Hardebeck, Tracie A. Paine, Cecelia Tannous-Taylor, Rachel Poyle, Emma Keppler, Sarah Brainard
Publikováno v:
Behavioural Brain Research. 414:113488
In humans, adverse childhood experiences are associated with an increased risk of developing a neuropsychiatric disorder. Changes in social behavior and cognitive function are hallmarks of numerous neuropsychiatric disorders. Here we examined the eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::678a5e59aa6e0d52cc6a657094d392ca
https://doi.org/10.1016/j.bbr.2021.113488
https://doi.org/10.1016/j.bbr.2021.113488
Publikováno v:
Behavioural Brain Research. 317:542-552
Introduction Decreased sociability is a symptom of psychiatric conditions including autism-spectrum disorder and schizophrenia. Both of these conditions are associated with decreases in GABA function, particularly in the medial prefrontal cortex (PFC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc099176928c6af4b2d64c2d2d65c42a
https://doi.org/10.1016/j.bbr.2016.10.012
https://doi.org/10.1016/j.bbr.2016.10.012
Publikováno v:
Behav Brain Res
INTRODUCTION: GABA dysfunction is associated with a number of psychiatric conditions including schizophrenia, autism and depression. Blocking cortical GABA(A) receptors in rodents causes behavioral deficits, including impaired attention and sociabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a9069b6918b4723a21cf6f7679a8be8b
https://pubmed.ncbi.nlm.nih.gov/31560920
https://pubmed.ncbi.nlm.nih.gov/31560920
Publikováno v:
Behavioural Brain Research. 378:112261
Introduction GABA dysfunction is associated with a number of psychiatric conditions including schizophrenia, autism and depression. Blocking cortical GABAA receptors in rodents causes behavioral deficits, including impaired attention and sociability,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48fe988902a66da3756b01a6b7f0cbba
https://doi.org/10.1016/j.bbr.2019.112261
https://doi.org/10.1016/j.bbr.2019.112261
Publikováno v:
Psychoneuroendocrinology. 91
The cognitive symptoms of schizophrenia are poorly understood and difficult to treat. Estrogens may mitigate these symptoms via unknown mechanisms. To examine these mechanisms, we tested whether increasing estradiol (E) or decreasing luteinizing horm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c65255f224dc076363a542eb621eaebf
https://pubmed.ncbi.nlm.nih.gov/29529524
https://pubmed.ncbi.nlm.nih.gov/29529524
The cognitive symptoms of schizophrenia are poorly understood and difficult to treat. Estrogens may mitigate these symptoms via unknown mechanisms. To examine these mechanisms, we tested whether increasing estradiol (E) or decreasing luteinizing horm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250b5c77035792b79e508cac9d956153
Publikováno v:
Psychopharmacology. 232:1755-1765
Decision-making is a complex cognitive process that is mediated, in part, by subregions of the medial prefrontal cortex (PFC). Decision-making is impaired in a number of psychiatric conditions including schizophrenia. Notably, people with schizophren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab7dbe39a0f43ff809f978652659bde8
https://doi.org/10.1007/s00213-014-3816-7
https://doi.org/10.1007/s00213-014-3816-7
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Previous work demonstrates that microinjections of dopamine D1 receptor agonists and antagonists directly into the medial prefrontal cortex (mPFC) of rats can affect attention in the 5-choice serial reaction time task (5CSRTT), a rodent test analogou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c13a5441e0053064580889e5d166c6
https://doi.org/10.1038/npp.2009.40
https://doi.org/10.1038/npp.2009.40
Autor:
Bryan L. Roth, David N. Potter, Tracie A. Paine, Bruce M. Cohen, Cécile Béguin, Loren Berry, Michele R. Richards, William A. Carlezon, Jennifer A. DiNieri, Zhiyang Zhao, Wei Xu, Lee-Yuan Liu-Chen, Thomas A. Munro
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 324:188-195
Several preclinical studies indicate that selective kappa-opioid receptor (KOR) antagonists have antidepressant-like effects, whereas KOR agonists have opposite effects, suggesting that each might be useful in the treatment of mood abnormalities. Sal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760e96feaa57fb570f39ed13c89dbac5
https://doi.org/10.1124/jpet.107.129023
https://doi.org/10.1124/jpet.107.129023
Publikováno v:
Biological Psychiatry. 62:687-693
Attentional deficits accompany many psychiatric disorders, underscoring the need for rodent models of attention to screen novel therapeutic agents and characterize the biological basis of attention. The five-choice serial reaction time task (5CSRTT)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6f52aab00a2390d52d1633d81674f8d
https://doi.org/10.1016/j.biopsych.2006.11.017
https://doi.org/10.1016/j.biopsych.2006.11.017