Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Traci Pawlowski"'
Autor:
Cristina Valero, Mahdi Golkaram, Joris L. Vos, Bin Xu, Conall Fitzgerald, Mark Lee, Shannon Kaplan, Catherine Y. Han, Xin Pei, Reith Sarkar, Lillian A. Boe, Abhinav Pandey, Elizabeth S. Koh, Charlotte L. Zuur, David B. Solit, Traci Pawlowski, Li Liu, Alan L. Ho, Diego Chowell, Nadeem Riaz, Timothy A. Chan, Luc G.T. Morris
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
BACKGROUND Recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) is generally an incurable disease, with patients experiencing median survival of under 10 months and significant morbidity. While immune checkpoint blockade (I
Externí odkaz:
https://doaj.org/article/a3ed24c58f7546a1a3e8b395d5a3c618
Autor:
Carolina Peixoto, Marta B. Lopes, Marta Martins, Sandra Casimiro, Daniel Sobral, Ana Rita Grosso, Catarina Abreu, Daniela Macedo, Ana Lúcia Costa, Helena Pais, Cecília Alvim, André Mansinho, Pedro Filipe, Pedro Marques da Costa, Afonso Fernandes, Paula Borralho, Cristina Ferreira, João Malaquias, António Quintela, Shannon Kaplan, Mahdi Golkaram, Michael Salmans, Nafeesa Khan, Raakhee Vijayaraghavan, Shile Zhang, Traci Pawlowski, Jim Godsey, Alex So, Li Liu, Luís Costa, Susana Vinga
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-23 (2023)
Abstract Colorectal cancer (CRC) is the third most common cancer and the second most deathly worldwide. It is a very heterogeneous disease that can develop via distinct pathways where metastasis is the primary cause of death. Therefore, it is crucial
Externí odkaz:
https://doaj.org/article/0d6a3817dc23495ca7e6cf3f2ada3dd4
Autor:
Mahdi Golkaram, Fengshen Kuo, Sounak Gupta, Maria I. Carlo, Michael L. Salmans, Raakhee Vijayaraghavan, Cerise Tang, Vlad Makarov, Phillip Rappold, Kyle A. Blum, Chen Zhao, Rami Mehio, Shile Zhang, Jim Godsey, Traci Pawlowski, Renzo G. DiNatale, Luc G. T. Morris, Jeremy Durack, Paul Russo, Ritesh R. Kotecha, Jonathan Coleman, Ying-Bei Chen, Victor E. Reuter, Robert J. Motzer, Martin H. Voss, Li Liu, Ed Reznik, Timothy A. Chan, A. Ari Hakimi
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-20 (2022)
Abstract Background Intratumoral heterogeneity (ITH) is a hallmark of clear cell renal cell carcinoma (ccRCC) that reflects the trajectory of evolution and influences clinical prognosis. Here, we seek to elucidate how ITH and tumor evolution during i
Externí odkaz:
https://doaj.org/article/8c4d235ff17b43c89e96ac2ab598a085
Autor:
Daniel Sobral, Marta Martins, Shannon Kaplan, Mahdi Golkaram, Michael Salmans, Nafeesa Khan, Raakhee Vijayaraghavan, Sandra Casimiro, Afonso Fernandes, Paula Borralho, Cristina Ferreira, Rui Pinto, Catarina Abreu, Ana Lúcia Costa, Shile Zhang, Traci Pawlowski, Jim Godsey, André Mansinho, Daniela Macedo, Soraia Lobo-Martins, Pedro Filipe, Rui Esteves, João Coutinho, Paulo Matos Costa, Afonso Ramires, Fernando Aldeia, António Quintela, Alex So, Li Liu, Ana Rita Grosso, Luis Costa
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
The genetic and microenvironmental heterogeneity of colorectal cancer is analyzed using a prospective biobank of primary and metastatic tumor tissues to highlight features of intra-tumoral heterogeneity that favor tumor progression and metastasis.
Externí odkaz:
https://doaj.org/article/521f8b4260d84b81a20a13cbf27320d4
Autor:
Mahdi Golkaram, Michael L. Salmans, Shannon Kaplan, Raakhee Vijayaraghavan, Marta Martins, Nafeesa Khan, Cassandra Garbutt, Aaron Wise, Joyee Yao, Sandra Casimiro, Catarina Abreu, Daniela Macedo, Ana Lúcia Costa, Cecília Alvim, André Mansinho, Pedro Filipe, Pedro Marques da Costa, Afonso Fernandes, Paula Borralho, Cristina Ferreira, Fernando Aldeia, João Malaquias, Jim Godsey, Alex So, Traci Pawlowski, Luis Costa, Shile Zhang, Li Liu
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-11 (2021)
Abstract Colorectal cancer (CRC) is one of the most lethal malignancies. The extreme heterogeneity in survival rate is driving the need for new prognostic biomarkers. Human endogenous retroviruses (hERVs) have been suggested to influence tumor progre
Externí odkaz:
https://doaj.org/article/957481dcdc6e4e478acc8a847c3b62c1
Autor:
Sylvie Rodrigues-Ferreira, Erwann le Rouzic, Traci Pawlowski, Anand Srivastava, Florence Margottin-Goguet, Clara Nahmias
Publikováno v:
International Journal of Hypertension, Vol 2013 (2013)
A complete renin-angiotensin system (RAS) is locally expressed in the brain and fulfills important functions. Angiotensin II, the major biologically active peptide of the RAS, acts via binding to two main receptor subtypes designated AT1 and AT2. The
Externí odkaz:
https://doaj.org/article/aafb699a08b44e30b4b8a4d0de9e108f
Autor:
Mahdi Golkaram, Fengshen Kuo, Sounak Gupta, Maria I. Carlo, Michael L. Salmans, Raakhee Vijayaraghavan, Cerise Tang, Vlad Makarov, Phillip Rappold, Kyle A. Blum, Chen Zhao, Rami Mehio, Shile Zhang, Jim Godsey, Traci Pawlowski, Renzo G. DiNatale, Luc GT Morris, Jeremy Durack, Paul Russo, Ritesh R. Kotecha, Jonathan Coleman, Ying-Bei Chen, Victor E Reuter, Robert J Motzer, Martin H. Voss, Li Liu, Ed Reznik, Timothy A. Chan, A. Ari Hakimi
BackgroundIntratumoral heterogeneity (ITH) is a hallmark of clear cell renal cell carcinoma (ccRCC) that reflects the trajectory of evolution and influences clinical prognosis. Here we seek to elucidate how ITH and tumor evolution during immune check
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c0628757baad8fa78da6d1564434a19
https://doi.org/10.1101/2022.07.11.22277322
https://doi.org/10.1101/2022.07.11.22277322
Autor:
Fernando Aldeia, Joyee Yao, Mahdi Golkaram, André Mansinho, Sandra Casimiro, Cristina Ferreira, Alex So, Ana Lúcia Costa, Aaron Wise, Cassandra Garbutt, Daniela Macedo, Catarina Abreu, Luis Costa, Pedro Filipe, Shannon Kaplan, Jim Godsey, Marta Martins, Traci Pawlowski, C. Alvim, Pedro Marques da Costa, Nafeesa Khan, Afonso Fernandes, Raakhee Vijayaraghavan, Paula Borralho, João Malaquias, Shile Zhang, Michael L. Salmans, Li Liu
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-11 (2021)
NPJ Genomic Medicine
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
NPJ Genomic Medicine
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
© The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to t
Autor:
Mahdi Golkaram, Timothy A. Chan, Christina S. Leslie, Victor E. Reuter, Raakhee Vijayaraghavan, Fengshen Kuo, Paul Russo, Kyrollis Attalla, Maria I. Carlo, Traci Pawlowski, Tanaya A. Purohit, Martin H. Voss, Chirag Krishna, Jonathan A. Coleman, Briana G. Nixon, Ming Liu, Stanley Weng, Raghvendra M. Srivastava, Sounak Gupta, Ming O. Li, Robert J. Motzer, Chad M. Vanderbilt, Michael L. Salmans, A. Ari Hakimi, Kyle A. Blum, Renzo G. DiNatale, Shile Zhang, Diego Chowell, Ying-Bei Chen, Vladimir Makarov, Lynda Vuong, Emily R. Kansler, Li Liu
Publikováno v:
Cancer Cell
Summary Clear cell renal cell carcinomas (ccRCCs) are highly immune infiltrated, but the effect of immune heterogeneity on clinical outcome in ccRCC has not been fully characterized. Here we perform paired single-cell RNA (scRNA) and T cell receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d70dd57eff1f3e311ee7f07d1e9ee9a2
https://europepmc.org/articles/PMC8268947/
https://europepmc.org/articles/PMC8268947/
Autor:
Traci Pawlowski, Yao Fu, Jin Hyun Ju, Tingting Jiang, Chen Zhao, Jenn Lococo, Jenhan Tao, Sven Bilke, Shile Zhang, Janel Dockter
BackgroundAs knowledge of mechanisms that drive the development of cancer grows, there has been corresponding growth in therapies specific to a mechanism. While these therapies show improvements in patient outcomes, they can be expensive and are effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92c9a8d33364562c4084658153e6537a
https://doi.org/10.1101/2020.10.21.349100
https://doi.org/10.1101/2020.10.21.349100