Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Traci L. Marin"'
Autor:
Jia-Bao Yan, Chien-Cheng Lai, Jin-Wei Jhu, Brendan Gongol, Traci L. Marin, Shih-Chieh Lin, Hsiang-Yi Chiu, Chia-Jui Yen, Liang-Yi Wang, I-Chen Peng
Publikováno v:
Molecular Therapy: Oncolytics, Vol 18, Iss , Pp 282-294 (2020)
Type 2 diabetes mellitus (T2DM) is a frequent comorbidity of cancer. Hyperinsulinemia secondary to T2DM promotes cancer progression, whereas antidiabetic agents, such as metformin, have anticancer effects. However, the detailed mechanism for insulin
Externí odkaz:
https://doaj.org/article/da5bff53a59746deb5db97a1ac31f057
Autor:
Fenqing Shang, Jiao Zhang, Zhao Li, Jin Zhang, Yanjun Yin, Yaqiong Wang, Traci L Marin, Brendan Gongol, Han Xiao, You-Yi Zhang, Zhen Chen, John Y-J Shyy, Ting Lei
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151845 (2016)
Hyperglycemia and hypertension impair endothelial function in part through oxidative stress-activated poly (ADP-ribose) polymerase 1 (PARP1). Biguanides and angiotensin II receptor blockers (ARBs) such as metformin and telmisartan have a vascular pro
Externí odkaz:
https://doaj.org/article/6d67c1cc5dd84580a3a75620846274a5
Autor:
Brendan Gongol, Jian Kang, Marcy Martin, John Y.-J. Shyy, Ming He, Fenqing Shang, Hsien Da Huang, Lili Chen, Xinxing Shi, Hsi-Yuan Huang, Yanjun Yin, Jin Zhang, Frank L. Powell, Yu Zhang, Traci L. Marin, Jiao Zhang, Zhen Chen, Patricia A. Thistlethwaite, Zuyi Yuan, Jianjie Dong, Esteban A. Moya, Yan Wu
Publikováno v:
American journal of respiratory and critical care medicine, vol 198, iss 4
American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine
RationaleEndothelial dysfunction plays an integral role in pulmonary hypertension (PH). AMPK (AMP-activated protein kinase) and ACE2 (angiotensin-converting enzyme 2) are crucial in endothelial homeostasis. The mechanism by which AMPK regulates ACE2
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 38
Background: A characteristic of atherosclerosis is the focal distribution of lesions in the arterial tree despite the systemic nature of cardiovascular impairments such as hyperlipidemia. While pulsatile shear stress (PS, atheroprotective) maintains
Publikováno v:
Methods in Molecular Biology ISBN: 9781493975976
In silico analysis of Big Data is a useful tool to identify putative kinase targets as well as nodes of signaling cascades that are difficult to discover by traditional single molecule experimentation. System approaches that use a multi-tiered invest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59e234ff831760819ba3d4c266d33323
https://doi.org/10.1007/978-1-4939-7598-3_7
https://doi.org/10.1007/978-1-4939-7598-3_7
Autor:
Othman Ghribi, Salvador Soriano, Wolff M. Kirsch, John David Jeppson, Harry V. Vinters, Nicholas Sanchez, Brendan Gongol, Karina Mayagoitia, Samuel Shin, Traci L. Marin, Christopher G. Wilson
Publikováno v:
Scientific reports, vol 7, iss 1
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports
The function of the amyloid precursor protein (APP) in brain health remains unclear. This study elucidated a novel cytoprotective signaling pathway initiated by the APP transcriptionally active intracellular domain (AICD) in response to 27-hydroxycho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11efb290041447dfb712e3a0f45794b8
https://escholarship.org/uc/item/4sz093nr
https://escholarship.org/uc/item/4sz093nr
Autor:
Traci L. Marin, Liang Wen, David A. Johnson, Brendan Gongol, Tzu-Pin Shentu, Yinsheng Wang, Fan Zhang, Yi Zhu, Jiao Zhang, John Y.-J. Shyy, Jianlin Zhang, Xiaoli Sun, Ming He, Gregory G. Geary
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology, vol 36, iss 12
Objective— Cortactin translocates to the cell periphery in vascular endothelial cells (ECs) on cortical–actin assembly in response to pulsatile shear stress. Because cortactin has putative sites for AMP-activated protein kinase (AMPK) phosphoryla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d4bb051561bf95e306fa50a0e71033
https://escholarship.org/uc/item/0105p0pv
https://escholarship.org/uc/item/0105p0pv
Autor:
Traci L. Marin, Zhen Chen, Shu Chien, Shankar Subramaniam, John Y.-J. Shyy, Brendan Gongol, Brian Woo
Publikováno v:
Free Radical Biology and Medicine. 64:61-68
Endothelial functions are highly regulated by imposed shear stress in vivo. The characteristics of shear stress determine mechanotransduction events that regulate phenotypic outcomes including redox and inflammatory states. Recent data indicates that
Autor:
Jiao Zhang, Zhen Chen, Youyi Zhang, Ting Lei, Han Xiao, Fenqing Shang, Traci L. Marin, Brendan Gongol, Zhao Li, Jin Zhang, Yanjun Yin, John Y.-J. Shyy, Yaqiong Wang
Publikováno v:
PloS one, vol 11, iss 3
PLoS ONE
PLoS ONE, Vol 11, Iss 3, p e0151845 (2016)
PLoS ONE
PLoS ONE, Vol 11, Iss 3, p e0151845 (2016)
Hyperglycemia and hypertension impair endothelial function in part through oxidative stress-activated poly (ADP-ribose) polymerase 1 (PARP1). Biguanides and angiotensin II receptor blockers (ARBs) such as metformin and telmisartan have a vascular pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1528ad0b2b291a4ded40e5da60d5262
https://escholarship.org/uc/item/9gp9c364
https://escholarship.org/uc/item/9gp9c364
Autor:
Frank Blaeser, I-Chen Peng, Zhen Chen, Traci L. Marin, Pang-Hung Hsu, David A. Johnson, Christian Lytle, John Y.-J. Shyy, Xiaopei Cui, Mei-I Su, Wei Sun, Songqin Pan, Talal A. Chatila, Ying-Shiuan Li
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 302:E1560-E1568
Glucagon is important for regulating lipid metabolism in part through its inhibition of fatty acid synthesis in adipocytes. Acetyl-CoA carboxylase 1 (ACC1) is the rate-limiting enzyme for fatty acid synthesis. Glucagon has been proposed to activate c