Výsledky vyhledávání - "Traci A Mansfield"

Efficacy and safety of dapagliflozin in Asian patients with type 2 diabetes after metformin failure: A randomized controlled trial

Autor: Nayyar Iqbal, Agata Ptaszynska, Kyung-Wan Min, Ping Han, Caroline T'joen, Bei Wang, Eva Johnsson, Traci A Mansfield, Wenying Yang

Publikováno v: Journal of Diabetes. 8:796-808

Background Dapagliflozin, a highly selective sodium–glucose cotransporter 2 inhibitor, reduces hyperglycemia, body weight, and blood pressure in patients with type 2 diabetes (T2D). Methods This randomized double-blind placebo-controlled parallel-g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94e059443e1d4116fe8da14053a1e0ab
https://doi.org/10.1111/1753-0407.12357

Zobrazit plný text záznamu

Plný text ve formátu HTML

Effects of dapagliflozin on blood pressure in hypertensive diabetic patients on renin-angiotensin system blockade

Autor: Federica Alessi, Shamik Parikh, Traci A Mansfield, Michael A. Weber, Agata Ptaszynska, Nayyar Iqbal

Publikováno v: Blood pressure. 25(2)

Hypertension and type 2 diabetes mellitus (T2DM) are risk factors for cardiovascular disease. Dapagliflozin improves glycemic control and systolic blood pressure (SBP) in T2DM patients. This double-blind phase III study evaluated the effects of dapag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1a4e2ddeb3ec8c55ca4d49d747535d5
https://pubmed.ncbi.nlm.nih.gov/27098403

Zobrazit plný text záznamu

Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis

Autor: Mary Jo Numerick, Kathleen I. MacKenzie, Bryan Goodwin, Guizhen Luo, Jane G Binz, Yaping Liu, Bhasha Desai, Steven A. Kliewer, Stacey A. Jones, Traci Ann Mansfield, Steve Dennis

Publikováno v: Journal of Clinical Investigation. 112:1678-1687

Farnesoid X receptor (FXR) is a bile acid-activated transcription factor that is a member of the nuclear hormone receptor superfamily. Fxr-null mice exhibit a phenotype similar to Byler disease, an inherited cholestatic liver disorder. In the liver,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a453e8fe33f06f634716d8bf074cbc1
https://doi.org/10.1172/jci18945

Zobrazit plný text záznamu

Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis

Autor: Steven A. Kliewer, Traci Ann Mansfield, Stacey A. Jones, Bryan Goodwin, Karen F. Kozarsky, Mary H Donahee, Andrew N. Billin, Y. Yvette McNeill, Da Yuan Wang, John E. Bisi, Jason A. Holt, Guizhen Luo

Publikováno v: Genes & Development. 17:1581-1591

The catabolism of cholesterol to bile acids represents a major pathway for the elimination of this potentially pathogenic sterol fromthe body. Bile acids subserve a number of important physiological functions, including the solubilization of choleste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::472233658b729187641f5e66465a7d21
https://doi.org/10.1101/gad.1083503

Zobrazit plný text záznamu

Application of toxicogenomics to drug development

Autor: Marc F DeCristofaro, Hans J Ahr, Maha M Lakkis, Traci A Mansfield

Publikováno v: Expert Review of Molecular Diagnostics. 2:337-345

The application of advanced modern biomedical and chemical research technologies in the pharmaceutical industry has led to a significant increase in the number of potential drug targets and lead candidates. Whereas the drug discovery process is enhan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2227b164f155020ad251b85feebcee87
https://doi.org/10.1586/14737159.2.4.337

Zobrazit plný text záznamu

The Chediak-Higashi Protein Interacts with SNARE Complex and Signal Transduction Proteins

Autor: John C. Detter, Velizar T. Tchernev, A. Madan Kumar, Jonathan M. Rothberg, Margaret R. Wallace, Vishnu S. Mishra, Krishnan Nandabalan, Loic Giot, Traci A. Mansfield, Stephen F. Kingsmore, Frederick S. Southwick, Ying Li

Publikováno v: Molecular Medicine. 8:56-64

BACKGROUND:Chediak-Higashi syndrome (CHS) is an inherited immunodeficiency disease characterized by giant lysosomes and impaired leukocyte degranulation. CHS results from mutations in the lysosomal trafficking regulator (LYST) gene, which encodes a 4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64705a8a607d3eb069bca97292475db6
https://doi.org/10.1007/bf03402003

Zobrazit plný text záznamu

Abstract 13640: Dapagliflozin Lowers HbA1c, Systolic Blood Pressure and Serum Uric Acid in Patients With Type 2 Diabetes and Hypertension, Regardless of Class of Concomitant Antihypertensive Therapy

Autor: Agata Ptaszynska, Shamik Parikh, Michael A. Weber, Nayyar Iqbal, Traci A Mansfield

Publikováno v: Circulation. 130

Hypertension (HTN) in Type 2 diabetes (T2D) is often treated with an ACEi/ARB + additional antihypertensives agents (AHTs). Dapagliflozin (DAPA) is an inhibitor of sodium glucose co-transporter 2, reducing hyperglycemia in T2D by increasing urinary g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd783c25539cf2dbdd8c636d9a67a961
https://doi.org/10.1161/circ.130.suppl_2.13640

Zobrazit plný text záznamu

Abstract 16107: Combined HbA1c and Systolic Blood Pressure Reduction With Dapagliflozin in Patients With Both Inadequately Controlled Type 2 Diabetes Mellitus and Hypertension

Autor: James F. List, Agata Ptaszynska, Traci A Mansfield, Michael A. Weber, Shamik Parikh

Publikováno v: Circulation. 130

Background: Hypertension is a common comorbidity in patients with type 2 diabetes mellitus (T2DM). Initial treatment is usually with an angiotensin-converting enzyme inhibitor (ACEi) or an angiotensin receptor blocker (ARB), with other antihypertensi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::30adfcf42cde12ad7c92b66e9680bb63
https://doi.org/10.1161/circ.130.suppl_2.16107

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání