Design of a Quantitative LC-MS Method for Residual Toxins Adenylate Cyclase Toxin (ACT), Dermonecrotic Toxin (DNT) and Tracheal Cytotoxin (TCT) in Bordetella pertussis Vaccines

Autor: Lisa Szymkowicz, Jeffery Gerard, Benjamin Messham, Wai Wan Vivian Tam, D. Andrew James

Publikováno v: Toxins, Vol 13, Iss 11, p 763 (2021)

The antigens for acellular pertussis vaccines are made up of protein components that are purified directly from Bordetella pertussis (B. pertussis) bacterial fermentation. As such, there are additional B. pertussis toxins that must be monitored as re

Externí odkaz: https://doaj.org/article/cc2c323c6ae141afa35d9bbd31203796

PGRP-LB: An Inside View into the Mechanism of the Amidase Reaction

Autor: Anna Zaidman-Rémy, Carole Vincent-Monégat, Pierre Aller, Allen M. Orville, Abdelaziz Heddi, A. Butryn, Pedro Da Silva, Laurent Soulère, Julien Orlans, Catherine Sivignon, Isabelle Rahioui

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2021, 22 (9), pp.4957. ⟨10.3390/ijms22094957⟩
Volume 22
Issue 9
International Journal of Molecular Sciences, Vol 22, Iss 4957, p 4957 (2021)

Peptidoglycan recognition proteins (PGRPs) are ubiquitous among animals and play pivotal functions in insect immunity. Non-catalytic PGRPs are involved in the activation of immune pathways by binding to the peptidoglycan (PGN), whereas amidase PGRPs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8b923bb48ee0b6c438d0d260ad3158
https://hal.archives-ouvertes.fr/hal-03237949

Design of a Quantitative LC-MS Method for Residual Toxins Adenylate Cyclase Toxin (ACT), Dermonecrotic Toxin (DNT) and Tracheal Cytotoxin (TCT) in Bordetella pertussis Vaccines

Autor: Wai Wan Vivian Tam, Benjamin Messham, Lisa Szymkowicz, D. Andrew James, Jeffery Gerard

Publikováno v: Toxins
Volume 13
Issue 11
Toxins, Vol 13, Iss 763, p 763 (2021)

The antigens for acellular pertussis vaccines are made up of protein components that are purified directly from Bordetella pertussis (B. pertussis) bacterial fermentation. As such, there are additional B. pertussis toxins that must be monitored as re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd1ed9ed746a6c498cc53ad11d4c7fdf
https://doi.org/10.3390/toxins13110763

Activity of Tracheal Cytotoxin of Bordetella pertussis in a Human Tracheobronchial 3D Tissue Model

Autor: David K, Kessie, Nina, Lodes, Heike, Oberwinkler, William E, Goldman, Thorsten, Walles, Maria, Steinke, Roy, Gross

Publikováno v: Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology, Vol 10 (2021)

Bordetella pertussis is a highly contagious pathogen which causes whooping cough in humans. A major pathophysiology of infection is the extrusion of ciliated cells and subsequent disruption of the respiratory mucosa. Tracheal cytotoxin (TCT) is the o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::08e1b1b8182b42cd6f77792e893281f8
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/22273

SLC46 Family Transporters Facilitate Cytosolic Innate Immune Recognition of Monomeric Peptidoglycans

Autor: Amanda J. Monahan, Donggi Paik, Roland Elling, William E. Goldman, Daniel R. Caffrey, Neal S. Silverman

Publikováno v: The Journal of Immunology. 199:263-270

Tracheal cytotoxin (TCT), a monomer of DAP-type peptidoglycan from Bordetella pertussis, causes cytopathology in the respiratory epithelia of mammals and robustly triggers the Drosophila Imd pathway. PGRP-LE, a cytosolic innate immune sensor in Droso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b762705fa19761b2fd0d3235595f2a3
https://doi.org/10.4049/jimmunol.1600409