Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Tracey Shipman"'
Autor:
Chunhui Jiang, Ashwani Kumar, Ze Yu, Tracey Shipman, Yong Wang, Renee M. McKay, Chao Xing, Lu Q. Le
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 12 (2023)
Neurofibromatosis type 1 (NF1) is one of the most common tumor-predisposing genetic disorders. Neurofibromas are NF1-associated benign tumors. A hallmark feature of neurofibromas is an abundant collagen-rich extracellular matrix (ECM) that constitute
Externí odkaz:
https://doaj.org/article/c58d1cf601994e0eb228352447eddcec
Autor:
Edem Tchegnon, Chung-Ping Liao, Elnaz Ghotbi, Tracey Shipman, Yong Wang, Renee M. McKay, Lu Q. Le
Publikováno v:
JCI Insight, Vol 6, Iss 20 (2021)
Dry eye disease affects over 16 million adults in the US, and the majority of cases are due to Meibomian gland dysfunction. Unfortunately, the identity of the stem cells involved in Meibomian gland development and homeostasis is not well elucidated.
Externí odkaz:
https://doaj.org/article/d956a931a5de4fc7b40d381a8a33922c
Schwannoma development is mediated by Hippo pathway dysregulation and modified by RAS/MAPK signaling
Autor:
Zhiguo Chen, Stephen Li, Juan Mo, Eric Hawley, Yong Wang, Yongzheng He, Jean-Philippe Brosseau, Tracey Shipman, D. Wade Clapp, Thomas J. Carroll, Lu Q. Le
Publikováno v:
JCI Insight, Vol 5, Iss 20 (2020)
Schwannomas are tumors of the Schwann cells that cause chronic pain, numbness, and potentially life-threatening impairment of vital organs. Despite the identification of causative genes, including NF2 (Merlin), INI1/SMARCB1, and LZTR1, the exact mole
Externí odkaz:
https://doaj.org/article/c7767e2f0eef47f9a10e9ecb1c27e92d
Autor:
Lu Q. Le, Thomas J. Carroll, Justin Guinney, Sara J.C. Gosline, Robert J. Allaway, Jonathan M. Cooper, Chung-Ping Liao, Yong Wang, Tracey Shipman, Jean-Philippe Brosseau, Juan Mo, Zhiguo Chen
Neurofibromatosis type 1 (NF1) is a cancer predisposition disorder that results from inactivation of the tumor suppressor neurofibromin, a negative regulator of RAS signaling. Patients with NF1 present with a wide range of clinical manifestations, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c56b657e5509d39827c991466ae76b1
https://doi.org/10.1158/2159-8290.c.6546817.v1
https://doi.org/10.1158/2159-8290.c.6546817.v1
Autor:
Elnaz Ghotbi, Renée M. McKay, Chung Ping Liao, Yong Wang, Tracey Shipman, Lu Q. Le, Edem Tchegnon
Publikováno v:
JCI Insight
Dry eye disease affects over 16 million adults in the US, and the majority of cases are due to Meibomian gland dysfunction. Unfortunately, the identity of the stem cells involved in Meibomian gland development and homeostasis is not well elucidated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc2e55bdf17e51f3dee93ead98fbb96d
https://doi.org/10.1172/jci.insight.151078
https://doi.org/10.1172/jci.insight.151078
Autor:
Stevie Johnson, Lauren R. Hepworth, Naomi Rainford, Fiona J. Rowe, Avril Drummond, Emma Bedson, Elizabeth J Conroy, Catherine Sackley, Claire Howard, Alex Pollock, Tracey Shipman, Marta García-Fiñana, Caroline Dodridge, Carmel P. Noonan
Publikováno v:
Eye (Lond)
Eye
Eye
Background: We conduct supplementary analyses of the NEI VFQ-25 data to evaluate where changes occurred within subscales of the NEI VFQ-25 leading to change in the composite scores between the three treatment arms, and evaluate the NEI VFQ-25 with an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a4f1f3066640852b1766e0a5848c6fc
https://doi.org/10.1038/s41433-019-0441-z
https://doi.org/10.1038/s41433-019-0441-z
Autor:
Tracey Shipman, Justin Guinney, Jonathan M. Cooper, Lu Q. Le, Thomas L. Carroll, Chung Ping Liao, Robert J. Allaway, Yong Wang, Sara J. C. Gosline, Zhiguo Chen, Jean-Philippe Brosseau, Juan Mo
Publikováno v:
Cancer Discovery. 9:114-129
Neurofibromatosis type 1 (NF1) is a cancer predisposition disorder that results from inactivation of the tumor suppressor neurofibromin, a negative regulator of RAS signaling. Patients with NF1 present with a wide range of clinical manifestations, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38be45107746e0c0a6faa6153db26ea6
https://doi.org/10.1158/2159-8290.cd-18-0151
https://doi.org/10.1158/2159-8290.cd-18-0151
Schwannoma development is mediated by Hippo pathway dysregulation and modified by RAS/MAPK signaling
Autor:
Thomas L. Carroll, Yongzheng He, Stephen Li, Tracey Shipman, Yong Wang, Lu Q. Le, Jean-Philippe Brosseau, Juan Mo, Zhiguo Chen, D. Wade Clapp, Eric T. Hawley
Publikováno v:
JCI Insight, Vol 5, Iss 20 (2020)
JCI Insight
JCI Insight
Schwannomas are tumors of the Schwann cells that cause chronic pain, numbness, and potentially life-threatening impairment of vital organs. Despite the identification of causative genes, including NF2 (Merlin), INI1/SMARCB1, and LZTR1, the exact mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39295c30535e7f98ee945f5c34e44e80
https://doi.org/10.1172/jci.insight.141514
https://doi.org/10.1172/jci.insight.141514
Autor:
Kevin Y. Yin, Juan Mo, Lu Q. Le, Zhiguo Chen, Corina Anastasaki, Jason B. Papke, Tracey Shipman, David H. Gutmann
Publikováno v:
J Clin Invest
Neurofibromatosis type 1 (NF1) is a common tumor predisposition syndrome caused by NF1 gene mutation, in which affected patients develop Schwann cell lineage peripheral nerve sheath tumors (neurofibromas). To investigate human neurofibroma pathogenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d68e4287f75028aa895ca7e87e75a2
https://pubmed.ncbi.nlm.nih.gov/33108355
https://pubmed.ncbi.nlm.nih.gov/33108355
Autor:
Zhiguo Chen, Jonathan M. Cooper, Jean-Philippe Brosseau, Juan Mo, Yong Wang, Justin Guinney, Sara J. C. Gosline, Thomas L. Carroll, Lu Q. Le, Robert J. Allaway, Chung Ping Liao, Tracey Shipman
Publikováno v:
Molecular Cancer Research. 18:B23-B23
The neurocutaneous tumor predisposition disorder neurofibromatosis Type I (NF1) results from deregulation of RAS signaling in the MAPK pathway that leads to a wide spectrum of clinical presentations. Dermal or cutaneous neurofibromas (cNF), a Schwann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50a76c8de3b574cb13a13af1eb56f2f0
https://doi.org/10.1158/1557-3125.hippo19-b23
https://doi.org/10.1158/1557-3125.hippo19-b23