Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Tracey L. Schultz"'
Autor:
Fengrong Wang, Michael J. Holmes, Hea Jin Hong, Pariyamon Thaprawat, Geetha Kannan, My-Hang Huynh, Tracey L. Schultz, M. Haley Licon, Sebastian Lourido, Wenzhao Dong, Jailson Brito Querido, William J. Sullivan, Seán E. O’Leary, Vern B. Carruthers
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The parasite Toxoplasma gondii persists in its hosts by converting from replicating tachyzoites to latent bradyzoites housed in tissue cysts. The molecular mechanisms that mediate T. gondii differentiation remain poorly understood. Through a
Externí odkaz:
https://doaj.org/article/344823925b104d6a82ccf0c94f14d18f
Autor:
Mack B. Reynolds, Benjamin Klein, Michael J. McFadden, Norah K. Judge, Hannah E. Navarrete, Britton C Michmerhuizen, Dominik Awad, Tracey L. Schultz, Paul W. Harms, Li Zhang, Teresa R. O’Meara, Jonathan Z. Sexton, Costas A. Lyssiotis, J. Michelle Kahlenberg, Mary X. O’Riordan
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114607- (2024)
Summary: Macrophage metabolic plasticity is central to inflammatory programming, yet mechanisms of coordinating metabolic and inflammatory programs during infection are poorly defined. Here, we show that type I interferon (IFN) temporally guides meta
Externí odkaz:
https://doaj.org/article/b80ebd8315f645efa79adec43f6f9598
Publikováno v:
mSphere, Vol 6, Iss 1 (2021)
Chronic infection of humans with Toxoplasma gondiiT. gondii
Externí odkaz:
https://doaj.org/article/069d182b8a5d4ee195a8f2a4de651223
Autor:
Geetha Kannan, Manlio Di Cristina, Aric J. Schultz, My-Hang Huynh, Fengrong Wang, Tracey L. Schultz, Matteo Lunghi, Isabelle Coppens, Vern B. Carruthers
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT Toxoplasma gondii is a ubiquitous pathogen that can cause encephalitis, congenital defects, and ocular disease. T. gondii has also been implicated as a risk factor for mental illness in humans. The parasite persists in the brain as slow-grow
Externí odkaz:
https://doaj.org/article/ae12df682df347df9a095dba059bb18f
Autor:
David Smith, Geetha Kannan, Isabelle Coppens, Fengrong Wang, Hoa Mai Nguyen, Aude Cerutti, Einar B Olafsson, Patrick A Rimple, Tracey L Schultz, Nayanna M Mercado Soto, Manlio Di Cristina, Sébastien Besteiro, Vern B Carruthers
Publikováno v:
eLife, Vol 10 (2021)
Many of the world’s warm-blooded species are chronically infected with Toxoplasma gondii tissue cysts, including an estimated one-third of the global human population. The cellular processes that permit long-term persistence within the cyst are lar
Externí odkaz:
https://doaj.org/article/7e32e96532dc4bf1a8c6d709d75c0a60
Autor:
Geetha Kannan, Isabelle Coppens, David Smith, Patrick A Rimple, Sébastien Besteiro, Manlio Di Cristina, Tracey L. Schultz, Einar B. Ólafsson, Aude Cerutti, Vern B. Carruthers, Nayanna M Mercado Soto, Hoa Mai Nguyen, Fengrong Wang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b54cdac166c46d044a59e3d3149530e
https://doi.org/10.7554/elife.59384.sa2
https://doi.org/10.7554/elife.59384.sa2
Publikováno v:
mSphere
mSphere, Vol 6, Iss 1 (2021)
mSphere, Vol 6, Iss 1 (2021)
Chronic infection of humans with Toxoplasma gondii is common, but little is known about how this intracellular parasite obtains the resources that it needs to persist indefinitely inside neurons and muscle cells. Here, we provide evidence that the ch
Autor:
Rolf W. Winter, Tracey L. Schultz, Vern B. Carruthers, Aaron Nilsen, Sovitj Pou, Alyssa J. Miller, Michael K. Riscoe, Rozalia Dodean, Lev N. Zakharov, Igor Bruzual, J. Stone Doggett
Publikováno v:
Antimicrob Agents Chemother
Toxoplasmosis is a potentially fatal infection for immunocompromised people and the developing fetus. Current medicines for toxoplasmosis have high rates of adverse effects that interfere with therapeutic and prophylactic regimens. Endochin-like quin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e4e76a1889fea9d2161ea769f0fe7b
https://europepmc.org/articles/PMC7449172/
https://europepmc.org/articles/PMC7449172/
Autor:
David Smith, Isabelle Coppens, Aude Cerutti, Patrick A Rimple, Fengrong Wang, Vern B. Carruthers, Geetha Kannan, Hao Mai Nugyen, Manlio Di Cristina, Sébastien Besteiro, Tracey L. Schultz
Many of the world’s warm-blooded species are chronically infected with Toxoplasma gondii tissue cysts, including up to an estimated one third of the global human population. The cellular processes that permit long-term parasite persistence within t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5aa186aac2527e1f664bbebf27a97dfd
https://doi.org/10.1101/2020.05.13.093401
https://doi.org/10.1101/2020.05.13.093401
Autor:
Tracey L. Schultz, Jason S. Knight, Basel H. Abuaita, Gautam Sule, Mary X. D. O'Riordan, Fushan Gao
Publikováno v:
J Immunol
Activation of the endoplasmic reticulum stress sensor, IRE1α, is required for effective immune responses against bacterial infection and is associated with human inflammatory diseases in which neutrophils are a key immune component. However, the spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d03430f0d734716b6f1a36150195a274