Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Tracey L. Bonfield"'
Autor:
Maya Breitman, Tracey L. Bonfield, Arnold I. Caplan, Hillard M. Lazarus, Maricela Haghiac, Susan LaSalvia, Jane Reese‐Koc, Nora G. Singer
Publikováno v:
ACR Open Rheumatology, Vol 4, Iss 2, Pp 152-160 (2022)
Objective Seropositive rheumatoid arthritis (RA) is a chronic autoimmune disease that is rarely “cured.” Human mesenchymal stem cells (hMSCs) are known to reduce inflammation and restore immune homeostasis. However, methods for predicting therape
Externí odkaz:
https://doaj.org/article/a7bd0d1395f0457a964cc475331d0a16
Autor:
Tracey L. Bonfield, Morgan T. Sutton, David R. Fletcher, Michael A. Folz, Vaishnavi Ragavapuram, Rodrigo A. Somoza, Arnold I. Caplan
Publikováno v:
Stem Cells Translational Medicine, Vol 10, Iss 8, Pp 1202-1216 (2021)
Abstract Chronic nontuberculous mycobacterial infections with Mycobacterium avium and Mycobacterium intracellulare complicate bronchiectasis, chronic obstructive airway disease, and the health of aging individuals. These insidious intracellular patho
Externí odkaz:
https://doaj.org/article/972fcace7d3b45f7bcc6940fc38549bb
Autor:
Asmaa Badr, Mostafa Eltobgy, Kathrin Krause, Kaitlin Hamilton, Shady Estfanous, Kylene P. Daily, Arwa Abu Khweek, Ahmad Hegazi, Midhun N. K. Anne, Cierra Carafice, Frank Robledo-Avila, Youssra Saqr, Xiaoli Zhang, Tracey L. Bonfield, Mikhail A. Gavrilin, Santiago Partida-Sanchez, Stephanie Seveau, Estelle Cormet-Boyaka, Amal O. Amer
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Cystic fibrosis (CF) human and mouse macrophages are defective in their ability to clear bacteria such as Burkholderia cenocepacia. The autophagy process in CF (F508del) macrophages is halted, and the underlying mechanism remains unclear. Furthermore
Externí odkaz:
https://doaj.org/article/db95827f79284dbaa804f925acce7f81
Autor:
Tracey L. Bonfield, Morgan T. Sutton, David R. Fletcher, Jane Reese-Koc, Erica A. Roesch, Hillard M. Lazarus, James F. Chmiel, Arnold I. Caplan
Publikováno v:
Pharmaceuticals, Vol 16, Iss 2, p 220 (2023)
Human Mesenchymal Stem Cell (hMSC) immunotherapy has been shown to provide both anti-inflammatory and anti-microbial effectiveness in a variety of diseases. The clinical potency of hMSCs is based upon an initial direct hMSC effect on the pro-inflamma
Externí odkaz:
https://doaj.org/article/2cce549d1cb548528d249719d866e57c
Autor:
Anna M. van Heeckeren, Morgan T. Sutton, David R. Fletcher, Craig A. Hodges, Arnold I. Caplan, Tracey L. Bonfield
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
In cystic fibrosis (CF), sustained infection and exuberant inflammation results in debilitating and often fatal lung disease. Advancement in CF therapeutics has provided successful treatment regimens for a variety of clinical consequences in CF; howe
Externí odkaz:
https://doaj.org/article/f294292e34c14157936f7f3bd9d36a6e
Publikováno v:
Journal of Inflammation, Vol 14, Iss 1, Pp 1-9 (2017)
Abstract Background Previous studies have demonstrated that ovalbumin sensitization promotes chronic asthma phenotype in murine asthma model. Human mesenchymal stem cells (hMSCs) are multipotent cells in vitro that have been shown to decrease inflamm
Externí odkaz:
https://doaj.org/article/4c09bd52230844b788ba3ebebffa288e
Publikováno v:
Microorganisms, Vol 7, Iss 2, p 42 (2019)
Infection with nontuberculous mycobacteria (NTM) is a complication of lung disease in immunocompromised patients, including those with human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS), chronic obstructive pulmonary dise
Externí odkaz:
https://doaj.org/article/b42675ef5e5742879e71bb0444fe108c
Autor:
Morgan T. Sutton, David Fletcher, Santosh K. Ghosh, Aaron Weinberg, Rolf van Heeckeren, Sukhmani Kaur, Zhina Sadeghi, Adonis Hijaz, Jane Reese, Hillard M. Lazarus, Donald P. Lennon, Arnold I. Caplan, Tracey L. Bonfield
Publikováno v:
Stem Cells International, Vol 2016 (2016)
Cystic fibrosis (CF) is a genetic disease in which the battle between pulmonary infection and inflammation becomes the major cause of morbidity and mortality. We have previously shown that human MSCs (hMSCs) decrease inflammation and infection in the
Externí odkaz:
https://doaj.org/article/4c5ba932ffc54167966f019169fbc28a
Autor:
Mary Jane Thomassen, Barbara P. Barna, Achut G. Malur, Tracey L. Bonfield, Carol F. Farver, Anagha Malur, Heidi Dalrymple, Mani S. Kavuru, Maria Febbraio
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 12, Pp 2762-2768 (2007)
Patients with pulmonary alveolar proteinosis (PAP) display impaired surfactant clearance, foamy, lipid-filled alveolar macrophages, and increased cholesterol metabolites within the lung. Neutralizing autoantibodies to granulocyte-macrophage colony-st
Externí odkaz:
https://doaj.org/article/edf14a86e6e14ce28086a80f415eb6e3
Autor:
Steve Meaney, Tracey L. Bonfield, Magnus Hansson, Amir Babiker, Mani S. Kavuru, Mary Jane Thomassen
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 12, Pp 2354-2360 (2004)
The conversion of cholesterol into the more polar metabolites 27-hydroxycholesterol (27-OH) and cholestenoic acid by the cytochrome P450 sterol 27-hydroxylase is a cholesterol-removal mechanism used by almost all cells. Most of the cholestenoic acid
Externí odkaz:
https://doaj.org/article/4d48a246a92b45fda1a6ed4719d995a0