Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Tracey J. Collard"'
Autor:
Danny N. Legge, Tracey J. Collard, Ewelina Stanko, Ashley J. Hoskin, Amy K. Holt, Caroline J. Bull, Madhu Kollareddy, Jake Bellamy, Sarah Groves, Eric H. Ma, Emma Hazelwood, David Qualtrough, Borko Amulic, Karim Malik, Ann C. Williams, Nicholas Jones, Emma E. Vincent
Publikováno v:
Molecular Metabolism, Vol 90, Iss , Pp 102037- (2024)
Colorectal cancer (CRC) is a multi-stage process initiated through the formation of a benign adenoma, progressing to an invasive carcinoma and finally metastatic spread. Tumour cells must adapt their metabolism to support the energetic and biosynthet
Externí odkaz:
https://doaj.org/article/b9bf09afa6cc4ffa9c8af160884748f0
Autor:
Amy K. Holt, Arafath K. Najumudeen, Tracey J. Collard, Hao Li, Laura M. Millett, Ashley J. Hoskin, Danny N. Legge, Eleanor M. H. Mortensson, Dustin J. Flanagan, Nicholas Jones, Madhu Kollareddy, Penny Timms, Matthew D. Hitchings, James Cronin, Owen J. Sansom, Ann C. Williams, Emma E. Vincent
Publikováno v:
Cancer & Metabolism, Vol 11, Iss 1, Pp 1-19 (2023)
Abstract Background To support proliferation and survival within a challenging microenvironment, cancer cells must reprogramme their metabolism. As such, targeting cancer cell metabolism is a promising therapeutic avenue. However, identifying tractab
Externí odkaz:
https://doaj.org/article/d2b8ee6de35a474887a1c18cb634d284
Autor:
Ashley J. Hoskin, Amy K. Holt, Danny N. Legge, Tracey J. Collard, Ann C. Williams, Emma E. Vincent
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 4, Iss 4, Pp 600-615 (2023)
Aspirin is a well-known nonsteroidal anti-inflammatory drug (NSAID) that has a recognized role in cancer prevention as well as evidence to support its use as an adjuvant for cancer treatment. Importantly there has been an increasing number of studies
Externí odkaz:
https://doaj.org/article/ea03b3ba9b3d41bda037c67e820ff463
Autor:
Alexander Greenhough, Clare Bagley, Kate J Heesom, David B Gurevich, David Gay, Mark Bond, Tracey J Collard, Chris Paraskeva, Paul Martin, Owen J Sansom, Karim Malik, Ann C Williams
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 11, Pp 1-13 (2018)
Abstract Hypoxia is a hallmark of solid tumours and a key physiological feature distinguishing cancer from normal tissue. However, a major challenge remains in identifying tractable molecular targets that hypoxic cancer cells depend on for survival.
Externí odkaz:
https://doaj.org/article/46c54f6455b9460fbdfd09461e4f6747
Autor:
Danny N. Legge, Alex P. Shephard, Tracey J. Collard, Alexander Greenhough, Adam C. Chambers, Richard W. Clarkson, Christos Paraskeva, Ann C. Williams
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 3 (2019)
To decrease bowel cancer incidence and improve survival, we need to understand the mechanisms that drive tumorigenesis. Recently, B-cell lymphoma 3 (BCL-3; a key regulator of NF-κB signalling) has been recognised as an important oncogenic player in
Externí odkaz:
https://doaj.org/article/cd9fde3343ff408689e9cb006bd97664
Autor:
Christopher Parker, Adam C. Chambers, Dustin J. Flanagan, Jasmine Wing Yu Ho, Tracey J. Collard, Greg Ngo, Duncan M. Baird, Penny Timms, Rhys G. Morgan, Owen J. Sansom, Ann C. Williams
Publikováno v:
Parker, C, Chambers, A C, Flanagan, D J, Ho, J W Y, Collard, T J, Ngo, G, Baird, D M, Timms, P, Morgan, R G, Sansom, O J & Williams, A C 2022, ' BCL-3 loss sensitises colorectal cancer cells to DNA damage by targeting homologous recombination ', DNA repair, vol. 115, 103331 . https://doi.org/10.1016/j.dnarep.2022.103331
The proto-oncogene BCL-3 is upregulated in a subset of colorectal cancers (CRC), where it has been shown to enhance tumour cell survival. However, although increased expression correlates with poor patient prognosis, the role of BCL-3 in determining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b79364554502afec628f6dd8f54280
Autor:
Peter A Johnson, Sara Menegatti, Adam C Chambers, Dominic Alibhai, Tracey J Collard, Ann C Williams, Hagan Bayley, Adam W Perriman
Publikováno v:
Biofabrication. 15(1)
We describe the development of a high-throughput bioprinted colorectal cancer (CRC) spheroid platform with high levels of automation, information content, and low cell number requirement. This is achieved via the formulation of a hydrogel bioink with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acac3d9e157101f46ebeb69bfc20cc80
https://pubmed.ncbi.nlm.nih.gov/36321254
https://pubmed.ncbi.nlm.nih.gov/36321254
Autor:
Danny N. Legge, Amy K. Holt, Caroline J. Bull, Tracey J. Collard, Madhu Kollareddy, Jake Bellamy, Sarah Groves, Eric H. Ma, Emma Hazelwood, David Qualtrough, Borko Amulic, Karim Malik, Ann C. Williams, Nicholas Jones, Emma E. Vincent
Colorectal cancer (CRC) is a multi-stage process initiated through the formation of a benign adenoma, progressing to an invasive carcinoma and finally metastatic spread. Tumour cells must adapt their metabolism to support the energetic and biosynthet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13803235ac78dcb8545a11cdcae5c234
https://doi.org/10.1101/2022.03.23.485483
https://doi.org/10.1101/2022.03.23.485483
Autor:
Danny Legge, Ann C. Williams, Tracey J Collard, Christopher Parker, Adam C. Chambers, Penny Timms
Publikováno v:
Carcinogenesis
Legge, D N, Chambers, A C, Parker, C T, Timms, P, Collard, T J & Williams, A C 2020, ' The role of B-Cell Lymphoma-3 (BCL-3) in enabling the hallmarks of cancer : implications for the treatment of colorectal carcinogenesis ', Carcinogenesis . https://doi.org/10.1093/carcin/bgaa003
Legge, D N, Chambers, A C, Parker, C T, Timms, P, Collard, T J & Williams, A C 2020, ' The role of B-Cell Lymphoma-3 (BCL-3) in enabling the hallmarks of cancer : implications for the treatment of colorectal carcinogenesis ', Carcinogenesis . https://doi.org/10.1093/carcin/bgaa003
With its identification as a proto-oncogene in chronic lymphocytic leukaemia and central role in regulating NF-κB signalling, it is perhaps not surprising that there have been an increasing number of studies in recent years investigating the role of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ba46ce8f7fd2b1f3897fe0e180f101
http://europepmc.org/articles/PMC7221501
http://europepmc.org/articles/PMC7221501
Autor:
Christopher Parker, Greg H.P. Ngo, Duncan M. Baird, Owen J. Sansom, Dustin J. Flanagan, Ann C. Williams, Adam C. Chambers, Rhys G. Morgan, Tracey J Collard, Penny Timms
ObjectiveThe proto-oncogene BCL-3 is upregulated in a subset of colorectal cancers (CRC) and increased expression of the gene correlates with poor patient prognosis. The aim is to investigate whether inhibiting BCL-3 can increase the response to DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::743f9ae6fd320dab2383458578eecc39
https://doi.org/10.1101/2021.08.03.454995
https://doi.org/10.1101/2021.08.03.454995