Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Tracey Gaspari"'
Autor:
Anika Vear, Amlan Chakraborty, Farnaz Fahimi, Dorota Ferens, Robert Widdop, Chrishan S. Samuel, Tracey Gaspari, Peter M. van Endert, Siew Yeen Chai
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The enzyme, insulin regulated aminopeptidase (IRAP), is expressed in multiple immune cells such as macrophages, dendritic cells and T cells, where it plays a role in regulating the innate and adaptive immune response. There is a genetic association b
Externí odkaz:
https://doaj.org/article/1a133e6d51724eebb5123264fcc28940
Development of a sandwich ELISA to detect circulating, soluble IRAP as a potential disease biomarker
Autor:
Anika Vear, Claudia Thalmann, Kristina Youngs, Natalie Hannan, Tracey Gaspari, Siew Yeen Chai
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract There is growing interest in the use of the enzyme, insulin regulated aminopeptidase (IRAP), as a biomarker for conditions such as cardio-metabolic diseases and ischemic stroke, with upregulation in its tissue expression in these conditions.
Externí odkaz:
https://doaj.org/article/f8537edf5e754a99b7f975ec160806c8
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
As a member of the M1 family of aminopeptidases, insulin regulated aminopeptidase (IRAP) is characterized by distinct binding motifs at the active site in the C-terminal domain that mediate the catalysis of peptide substrates. However, what makes IRA
Externí odkaz:
https://doaj.org/article/2ea2031e37894859aa5ff554b87b8308
Autor:
Robert E Widdop, Katrina M Mirabito Colafella, Tracey Gaspari, Edmund Kwok, Anita A. Pinar, Giannie Barsha, Sarah L. Walton, Kate M. Denton, Chrishan S. Samuel, Lucinda M. Hilliard Krause
Publikováno v:
Kidney360
BACKGROUND: The antifibrotic effects of recombinant human relaxin (RLX) in the kidney are dependent on an interaction between its cognate receptor (RXFP1) and the angiotensin type 2 receptor (AT(2)R) in male models of disease. Whether RLX has therape
Autor:
Yan Wang, Sarah L. Walton, Emma S Jones, Chrishan S. Samuel, Tracey Gaspari, Kate M. Denton, Iresha Spizzo, Matthew Shen, Lei Han, Robert E Widdop
Publikováno v:
ACS Pharmacology & Translational Science. 3:76-87
Fibrosis is involved in the majority of cardiovascular diseases and is a key contributor to end-organ dysfunction. In the current study, the antifibrotic effects of recombinant human relaxin-2 (serelaxin; RLX) and/or the AT2R agonist CGP42112 (CGP) w
Autor:
Yung-Chih Chen, Berkay Ozcelik, David M. Kaye, Hong Bin Liu, Robert E Widdop, Melissa Byrne, Tracey Gaspari, Anthony E. Dear, Ashley Walker, Patrick Perlmutter, Keith Byron, Gopal R. Sama, Jegadesan Subbiah
Publikováno v:
Cardiovascular Drugs and Therapy. 33:687-692
Drug-eluting balloon catheters (DEBc) coated with paclitaxel (PTX) have been associated with potential safety concerns. An efficacious but less toxic balloon coating may reduce these outcomes. We evaluated a novel DEBc, Epi-Solve, coated with metacep
Autor:
Giannie Barsha, Katrina M Mirabito Colafella, Sarah L. Walton, Robert E Widdop, Lucinda M. Hilliard Krause, Tracey Gaspari, Kate M. Denton, Anita A. Pinar, Chrishan S. Samuel, Iresha Spizzo
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 78(1)
Loss of ovarian hormones following menopause contributes to the rise in cardiovascular risk with age. Estrogen plays a protective role against hypertension and end-organ damage by modulating the depressor actions of the AT 2 R (angiotensin type 2 rec
Autor:
Chrishan S. Samuel, Dorota Ferens, Barbara K Kemp-Harper, Tracey Gaspari, Chao Wang, Iresha Spizzo
Publikováno v:
British journal of pharmacologyREFERENCES. 178(12)
Background and purpose Oxidative stress and fibrosis are hallmarks of cardiomyopathy-induced heart failure yet are not effectively targeted by current frontline therapies. Here, the therapeutic effects of the anti-oxidant, N-acetylcysteine (NAC), wer
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 11 (2020)
Frontiers in Pharmacology, Vol 11 (2020)
Introduction The NLRP3 inflammasome produces interleukin (IL)-1β and IL-18, which when chronically activated by transforming growth factor (TGF)-β1, contribute to fibrosis. The recombinant form of the anti-fibrotic hormone, relaxin (RLX), suppresse
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 33(12)
The recombinant form of the peptide hormone relaxin, serelaxin (RLX), mediates its anti-fibrotic actions by impeding the profibrotic activity of cytokines including TGF-β1 and IL-1β. As IL-1β can be produced by the nucleotide-binding oligomerizati