Zobrazeno 1 - 10
of 185
pro vyhledávání: '"Tracey D Bradshaw"'
Autor:
Hsien-Chuen Soo, Felicia Fei-Lei Chung, Kuan-Hon Lim, Veronica Alicia Yap, Tracey D Bradshaw, Ling-Wei Hii, Si-Hoey Tan, Sze-Jia See, Yuen-Fen Tan, Chee-Onn Leong, Chun-Wai Mai
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170551 (2017)
Cudraflavone C (Cud C) is a naturally-occurring flavonol with reported anti-proliferative activities. However, the mechanisms by which Cud C induced cytotoxicity have yet to be fully elucidated. Here, we investigated the effects of Cud C on cell prol
Externí odkaz:
https://doaj.org/article/cb15df37fbdb4053972dc53a1cb5dd41
Autor:
Alice Brookes, Nicholas Kindon, David J. Scurr, Morgan R. Alexander, Pavel Gershkovich, Tracey D. Bradshaw
Publikováno v:
BJC Reports, Vol 2, Iss 1, Pp 1-10 (2024)
Abstract Background Glioblastoma multiforme (GBM) is an aggressive cancer with poor prognosis, partly due to resistance to the standard chemotherapy treatment, temozolomide (TMZ). Phytocannabinoid cannabidiol (CBD) has exhibited anti-cancer effects a
Externí odkaz:
https://doaj.org/article/1706df332e8f4056b98192755818f7ac
Autor:
Mohammed Zuhair Al-Hayali, Choy-Eng Nge, Kuan Hon Lim, Hilary M. Collins, Toh-Seok Kam, Tracey D. Bradshaw
Publikováno v:
Molecules, Vol 29, Iss 11, p 2654 (2024)
Natural products contribute substantially to anticancer therapy; the plant kingdom provides an important source of molecules. Conofolidine is a novel Aspidosperma-Aspidosperma bisindole alkaloid isolated from the Malayan plant Tabernaemontana corymbo
Externí odkaz:
https://doaj.org/article/d5b3d51d6b3d4a9195e365bb4d7c2698
Autor:
Maysaa M. Saleh, Duaa A. Abuarqoub, Alaa M. Hammad, Md Shahadat Hossan, Najneen Ahmed, Nazneen Aslam, Abdallah Y. Naser, Christopher J. Moody, Charles A. Laughton, Tracey D. Bradshaw
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 1, Pp 175-196 (2022)
Here, we describe the anticancer activity of our novel bis-triazoles MS47 and MS49, developed previously as G-quadruplex stabilizers, focusing specifically upon the human melanoma MDA-MB-435 cell line. At the National Cancer Institute (NCI), USA, bis
Externí odkaz:
https://doaj.org/article/29394440f6aa4e28ab41123f12ea813e
Autor:
Haneen Abuzaid, Salah Abdelrazig, Lenny Ferreira, Hilary M. Collins, Dong-Hyun Kim, Kuan-Hon Lim, Toh-Seok Kam, Neil R. Thomas, Lyudmila Turyanska, Tracey D. Bradshaw
Publikováno v:
ACS Omega, Vol 9, Iss 1, Pp 2012-2012 (2023)
Externí odkaz:
https://doaj.org/article/9b131eac926943a483f5c1ebd851ad6d
Autor:
Christopher J. Smedley, Paul A. Stanley, Mohannad E. Qazzaz, Andrea E. Prota, Natacha Olieric, Hilary Collins, Harry Eastman, Andrew S. Barrow, Kuan-Hon Lim, Toh-Seok Kam, Brian J. Smith, Hendrika M. Duivenvoorden, Belinda S. Parker, Tracey D. Bradshaw, Michel O. Steinmetz, John E. Moses
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
Abstract The jerantinine family of Aspidosperma indole alkaloids from Tabernaemontana corymbosa are potent microtubule-targeting agents with broad spectrum anticancer activity. The natural supply of these precious metabolites has been significantly d
Externí odkaz:
https://doaj.org/article/cd703e3a1db842d9bf536015c27b64dc
Publikováno v:
Molecules, Vol 26, Iss 17, p 5136 (2021)
Thymoquinone (TQ) is the main biologically active constituent of Nigella sativa. Many studies have confirmed its anticancer actions. Herein, we investigated the different anticancer activities of, and considered resistance mechanisms to, TQ. MTT and
Externí odkaz:
https://doaj.org/article/84f81caee3e8469c84d56d49e6f963b2
Autor:
Chee-Onn Leong, Malcolm F.G. Stevens, Tracey D. Bradshaw, Heng Lungh Choo, Nirmal Randhawa, Ashwin Muruhadas, Kai Hung Tiong, Boon Shing Tan
PDF file - 64K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c0e9465ad4a531af2ba888341fb366
https://doi.org/10.1158/1535-7163.22496415.v1
https://doi.org/10.1158/1535-7163.22496415.v1
Autor:
Chee-Onn Leong, Malcolm F.G. Stevens, Tracey D. Bradshaw, Heng Lungh Choo, Nirmal Randhawa, Ashwin Muruhadas, Kai Hung Tiong, Boon Shing Tan
PDF file - 569K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a74a6bf280570d8fd314b8501dcde481
https://doi.org/10.1158/1535-7163.22496412
https://doi.org/10.1158/1535-7163.22496412
Autor:
Chee-Onn Leong, Malcolm F.G. Stevens, Tracey D. Bradshaw, Heng Lungh Choo, Nirmal Randhawa, Ashwin Muruhadas, Kai Hung Tiong, Boon Shing Tan
Both 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F-203; NSC 703786) and 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW-610; NSC 721648) are antitumor agents with novel mechanism(s). Previous studies have indicated that cytochrome (CYP) P450
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d3d3106604927bfb2cf8eff32dc1c6
https://doi.org/10.1158/1535-7163.c.6535263.v1
https://doi.org/10.1158/1535-7163.c.6535263.v1