Zobrazeno 1 - 10
of 301
pro vyhledávání: '"Tracey D Bradshaw"'
Autor:
Alice Brookes, Nicholas Kindon, David J. Scurr, Morgan R. Alexander, Pavel Gershkovich, Tracey D. Bradshaw
Publikováno v:
BJC Reports, Vol 2, Iss 1, Pp 1-10 (2024)
Abstract Background Glioblastoma multiforme (GBM) is an aggressive cancer with poor prognosis, partly due to resistance to the standard chemotherapy treatment, temozolomide (TMZ). Phytocannabinoid cannabidiol (CBD) has exhibited anti-cancer effects a
Externí odkaz:
https://doaj.org/article/1706df332e8f4056b98192755818f7ac
Autor:
Mohammed Zuhair Al-Hayali, Choy-Eng Nge, Kuan Hon Lim, Hilary M. Collins, Toh-Seok Kam, Tracey D. Bradshaw
Publikováno v:
Molecules, Vol 29, Iss 11, p 2654 (2024)
Natural products contribute substantially to anticancer therapy; the plant kingdom provides an important source of molecules. Conofolidine is a novel Aspidosperma-Aspidosperma bisindole alkaloid isolated from the Malayan plant Tabernaemontana corymbo
Externí odkaz:
https://doaj.org/article/d5b3d51d6b3d4a9195e365bb4d7c2698
Autor:
Maysaa M. Saleh, Duaa A. Abuarqoub, Alaa M. Hammad, Md Shahadat Hossan, Najneen Ahmed, Nazneen Aslam, Abdallah Y. Naser, Christopher J. Moody, Charles A. Laughton, Tracey D. Bradshaw
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 1, Pp 175-196 (2022)
Here, we describe the anticancer activity of our novel bis-triazoles MS47 and MS49, developed previously as G-quadruplex stabilizers, focusing specifically upon the human melanoma MDA-MB-435 cell line. At the National Cancer Institute (NCI), USA, bis
Externí odkaz:
https://doaj.org/article/29394440f6aa4e28ab41123f12ea813e
Autor:
Haneen Abuzaid, Salah Abdelrazig, Lenny Ferreira, Hilary M. Collins, Dong-Hyun Kim, Kuan-Hon Lim, Toh-Seok Kam, Neil R. Thomas, Lyudmila Turyanska, Tracey D. Bradshaw
Publikováno v:
ACS Omega, Vol 9, Iss 1, Pp 2012-2012 (2023)
Externí odkaz:
https://doaj.org/article/9b131eac926943a483f5c1ebd851ad6d
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-9 (2020)
Abstract Background Acute myeloid leukemia (AML) is a heterogenous hematological malignancy with poor long-term survival. New drugs which improve the outcome of AML patients are urgently required. In this work, the activity and mechanism of action of
Externí odkaz:
https://doaj.org/article/e057621f1adb4b8980ea362a8c28884b
Autor:
Christopher J. Smedley, Paul A. Stanley, Mohannad E. Qazzaz, Andrea E. Prota, Natacha Olieric, Hilary Collins, Harry Eastman, Andrew S. Barrow, Kuan-Hon Lim, Toh-Seok Kam, Brian J. Smith, Hendrika M. Duivenvoorden, Belinda S. Parker, Tracey D. Bradshaw, Michel O. Steinmetz, John E. Moses
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
Abstract The jerantinine family of Aspidosperma indole alkaloids from Tabernaemontana corymbosa are potent microtubule-targeting agents with broad spectrum anticancer activity. The natural supply of these precious metabolites has been significantly d
Externí odkaz:
https://doaj.org/article/cd703e3a1db842d9bf536015c27b64dc
Publikováno v:
Molecules, Vol 26, Iss 17, p 5136 (2021)
Thymoquinone (TQ) is the main biologically active constituent of Nigella sativa. Many studies have confirmed its anticancer actions. Herein, we investigated the different anticancer activities of, and considered resistance mechanisms to, TQ. MTT and
Externí odkaz:
https://doaj.org/article/84f81caee3e8469c84d56d49e6f963b2
Autor:
Zhikuan Yang, Danping Wei, Xiaoli Dai, Malcolm F. G. Stevens, Tracey D. Bradshaw, Ying Luo, Jihong Zhang
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Temozolomide (TMZ) is the standard of care chemotherapeutic agent used in the treatment of glioblastoma multiforme. Cytotoxic O6-methylguaine lesions formed by TMZ are repaired by O6-methyl-guanine DNA methyltransferase (MGMT), a DNA repair protein t
Externí odkaz:
https://doaj.org/article/c4b941dd7ef84b71977c1b194ddd4c9b
Autor:
Haneen Abuzaid, Salah Abdelrazig, Lenny Ferreira, Hilary M. Collins, Dong-Hyun Kim, Kuan-Hon Lim, Toh-Seok Kam, Lyudmila Turyanska, Tracey D. Bradshaw
Publikováno v:
ACS Omega. 7:21473-21482
The O-acetyl (or acetate) derivative of the Aspidosperma alkaloid Jerantinine A (JAa) elicits anti-tumor activity against cancer cell lines including mammary carcinoma cell lines irrespective of receptor status (0.14 < GI 50 < 0.38 ?M), targeting mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64866e0e5ce8a09d5d218cf7f55112c
https://doi.org/10.1021/acsomega.2c00997
https://doi.org/10.1021/acsomega.2c00997
Autor:
Md Shahadat Hossan, Mohammed Khaled Bin Break, Tracey D. Bradshaw, Hilary M. Collins, Christophe Wiart, Teng-Jin Khoo, Ahmed Alafnan
Publikováno v:
Molecules, Vol 26, Iss 8, p 2166 (2021)
Cardamonin is a polyphenolic natural product that has been shown to possess cytotoxic activity against a variety of cancer cell lines. We previously reported the semi-synthesis of a novel Cu (II)–cardamonin complex (19) that demonstrated potent ant
Externí odkaz:
https://doaj.org/article/acfcd2d18431437f8827808850156592