Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Tracey C, Dickson"'
Autor:
Rosemary M. Clark, Courtney M. Clark, Katherine E.A. Lewis, Marcus S. Dyer, Jyoti A. Chuckowree, Joshua A. Hoyle, Catherine A. Blizzard, Tracey C. Dickson
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 11, Pp 1985-1999 (2023)
Abstract Objective Neuropeptide Y (NPY) is a 36 amino acid peptide widely considered to provide neuroprotection in a range of neurodegenerative diseases. In the fatal motor neuron disease amyotrophic lateral sclerosis (ALS), recent evidence supports
Externí odkaz:
https://doaj.org/article/246d624c3fe4468296d9e6f8d246f7ba
Autor:
Courtney M. Clark, Rosemary M. Clark, Joshua A. Hoyle, Jyoti A. Chuckowree, Catriona A. McLean, Tracey C. Dickson
Publikováno v:
Brain Sciences, Vol 11, Iss 8, p 969 (2021)
Destabilization of faciliatory and inhibitory circuits is an important feature of corticomotor pathology in amyotrophic lateral sclerosis (ALS). While GABAergic inputs to upper motor neurons are reduced in models of the disease, less understood is th
Externí odkaz:
https://doaj.org/article/e24cf93696fb4f5e97b28aafb4c4edc3
Autor:
Tongcui Jiang, Emily Handley, Mariana Brizuela, Edgar Dawkins, Katherine E. A. Lewis, Rosemary M. Clark, Tracey C. Dickson, Catherine A. Blizzard
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 5 (2019)
Altered cortical excitability and synapse dysfunction are early pathogenic events in amyotrophic lateral sclerosis (ALS) patients and animal models. Recent studies propose an important role for TAR DNA-binding protein 43 (TDP-43), the mislocalization
Externí odkaz:
https://doaj.org/article/8a83b675ca364f0e947dde3eff0b5c6d
Autor:
Emily E. Handley, Laura A. Reale, Jyoti A. Chuckowree, Marcus S. Dyer, Grace L. Barnett, Courtney M. Clark, William Bennett, Tracey C. Dickson, Catherine A. Blizzard
Publikováno v:
Molecular Neurobiology. 59:2962-2976
Amyotrophic lateral sclerosis (ALS) attacks the corticomotor system, with motor cortex function affected early in disease. Younger females have a lower relative risk of succumbing to ALS than males and older females, implicating a role for female sex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec2b659104244da6797292227d5d5c36
https://doi.org/10.1007/s12035-022-02742-5
https://doi.org/10.1007/s12035-022-02742-5
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Cortical interneurons play a crucial role in regulating inhibitory-excitatory balance in brain circuits, filtering synaptic information and dictating the activity of pyramidal cells through the release of GABA. In the fatal motor neuron (MN) disease,
Externí odkaz:
https://doaj.org/article/ca502a7e74c5473fa48c435db04941fe
Autor:
Jyoti A. Chuckowree, Zhendan Zhu, Mariana Brizuela, Ka M. Lee, Catherine A. Blizzard, Tracey C. Dickson
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Microtubule dynamics underpin a plethora of roles involved in the intricate development, structure, function, and maintenance of the central nervous system. Within the injured brain, microtubules are vulnerable to misalignment and dissolution in neur
Externí odkaz:
https://doaj.org/article/1ac09fb2ab064fbda24c55a121f0ab6b
Autor:
Catherine A. Blizzard, Katherine A. Southam, Edgar Dawkins, Katherine E. Lewis, Anna E. King, Jayden A. Clark, Tracey C. Dickson
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 3, Pp 215-224 (2015)
There is a desperate need for targeted therapeutic interventions that slow the progression of amyotrophic lateral sclerosis (ALS). ALS is a disorder with heterogeneous onset, which then leads to common final pathways involving multiple neuronal compa
Externí odkaz:
https://doaj.org/article/f0fdcd3ed3b842c586a30e775dcb3170
Autor:
Laura A. Reale, Marcus S. Dyer, Sharn E. Perry, Kaylene M. Young, Tracey C. Dickson, Adele Woodhouse, Catherine A. Blizzard
Publikováno v:
Progress in Neurobiology. 226:102449
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0f65913abcab975a999a9f9fd877fe7
https://doi.org/10.1016/j.pneurobio.2023.102449
https://doi.org/10.1016/j.pneurobio.2023.102449
Autor:
Yiing C Yap, Anna E King, Rosanne M Guijt, Tongcui Jiang, Catherine A Blizzard, Michael C Breadmore, Tracey C Dickson
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176997 (2017)
Diffuse axonal injury is a hallmark pathological consequence of non-penetrative traumatic brain injury (TBI) and yet the axonal responses to stretch injury are not fully understood at the cellular level. Here, we investigated the effects of mild (5%)
Externí odkaz:
https://doaj.org/article/a1f39c603f884c8fad873c027ddf4c01
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 10 (2016)
Amyotrophic lateral sclerosis (ALS) is an aggressive multifactorial disease converging on a common pathology: the degeneration of motor neurons, their axons and neuromuscular synapses. This vulnerability and dysfunction of motor neurons highlights th
Externí odkaz:
https://doaj.org/article/6ecefe648c8f4366b5fbecf414b551f3