Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Tracey Ashmeade"'
Autor:
Tracey Ashmeade, David Virley, Andrew Billinton, Mark E. P. Hows, Angela A Austin, Ajit J. Shah, Marion J. Perren, Andrew J. Organ
Publikováno v:
Journal of Neuroscience Methods. 137:221-226
A high-throughput liquid chromatography/tandem mass spectrometry method has been developed for the quantitative assessment of 1-methyl-4-phenylpyridinium (MPP+) in brain tissue samples. This separation is based on reversed phase chromatography using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c4d5f9884c521fbdf15a3df8ef595f
https://doi.org/10.1016/j.jneumeth.2004.02.011
https://doi.org/10.1016/j.jneumeth.2004.02.011
Publikováno v:
European Journal of Pharmacology. 493:95-98
The vasoactive peptide urotensin-II and its receptor, GPR14 (now known as UT receptor), are localised in the mammalian central nervous system. Accordingly, various centrally mediated effects of urotensin-II on behaviour, neuroendocrine hormones and n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a081b94ce4ba4cc2e30ad209bbcd40d8
https://doi.org/10.1016/j.ejphar.2004.04.009
https://doi.org/10.1016/j.ejphar.2004.04.009
Autor:
F Parker, S.G. Taylor, J.P. Hatcher, Carol Routledge, A J Hunter, Declan N.C. Jones, Tracey Ashmeade, Jim J. Hagan, Jane Gartlon, Neil Upton, Roderick A. Porter, Amanda Johns, P. Hemmati, R.P. Munton
Publikováno v:
Psychopharmacology. 153:210-218
Rationale: Orexin-A and orexin-B are hypothalamic neuropeptides derived from a 130-amino acid precursor, prepro-orexin, and are potent agonists at both the orexin-1 (OX1) and orexin-2 (OX2) receptors. Orexin-A has been ascribed a number of in vivo fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff5e90bfeae294ee69addafc1507c862
https://doi.org/10.1007/s002130000551
https://doi.org/10.1007/s002130000551
Autor:
T Chapman, Ian C B Marshall, David R. Howlett, A. Lawman, Jill C. Richardson, Simon T. Bate, Peter J. B. Anderson, Christopher J. Hille, Sarah Collier, Tracey Ashmeade, Karen Louise Philpott
Publikováno v:
Experimental brain research. 214(2)
Amyloid-induced inflammation is thought to play a critical and early role in the pathophysiology of Alzheimer's disease. As such, robust models with relevant and accessible compartments that provide a means of assessing anti-inflammatory agents are e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b1ce2058b6bd06b76fe91b436c71e4
https://pubmed.ncbi.nlm.nih.gov/21850448
https://pubmed.ncbi.nlm.nih.gov/21850448
Autor:
Neil Upton, Simon T. Bate, Marion J. Perren, Flora Joyce, Jill C. Richardson, Tracey Ashmeade, Ainsley A. Culbert, David Virley, David Sunter, Zoe Seymour, Martin P. Vidgeon-Hart, Anna Babin, Perdita L. Pugh
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 4, Iss 1, p 8 (2007)
Journal of Neuroinflammation, Vol 4, Iss 1, p 8 (2007)
Background Data indicates anti-oxidant, anti-inflammatory and pro-cognitive properties of noradrenaline and analyses of post-mortem brain of Alzheimer's disease (AD) patients reveal major neuronal loss in the noradrenergic locus coeruleus (LC), the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d23f497a6835ad219a7d2a9664abc1
https://pubmed.ncbi.nlm.nih.gov/17324270
https://pubmed.ncbi.nlm.nih.gov/17324270
Autor:
Ainsley A. Culbert, Perdita L. Pugh, Anna Babin, Simon T. Bate, Martin P. Vidgeon-Hart, Tracey Ashmeade, David Virley, Neil Upton, David Sunter, Zoe Seymour
Publikováno v:
Alzheimer's & Dementia. 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1f9d0e7faf1c3f92efe18b95cd591c1
https://doi.org/10.1016/j.jalz.2006.05.402
https://doi.org/10.1016/j.jalz.2006.05.402
Autor:
Philip G. Szekeres, Jim J. Hagan, Klaudia Steplewski, Nabil Elshourbagy, Shelagh Wilson, Declan N.C. Jones, David Michalovich, Tracey Ashmeade, Paul R. Murdock, Abdel Ennaceur, Mark S. Duxon, Mark Pullen, Cathy Ellis, Alan R. Atkins, Jane Gartlon, A. Jackie Hunter, Usman Shabon, Nambi Aiyar, Henry M. Sarau, Christian Heidbreder, David C. Harrison
Rationale: Neuromedin-U (NmU) is an agonist at NMU1R and NMU2R. The brain distribution of NmU and its receptors, in particular NMU2R, suggests widespread central roles for NmU. In agreement, centrally administered NmU affects feeding behaviour, energ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a33d44a40c1538447a9bdf533f7c75
Autor:
and Carole Routledge, Nigel E. Austin, Tracey Ashmeade, Charlie Reavill, A. Jacqueline Hunter, Clive Leslie Branch, Derek N. Middlemiss, Geoffrey Stemp, Vong Antonio Kuok Keong, Kevin M. Thewlis, Izzy Boyfield, Christopher N. Johnson, Jim J. Hagan, Phillip Jeffrey, Graham J. Riley, David John Nash, Martyn D. Wood, Kim Y. Avenell, Michael S. Hadley
Publikováno v:
Journal of medicinal chemistry. 43(9)
A selective dopamine D(3) receptor antagonist offers the potential for an effective antipsychotic therapy, free of the serious side effects of currently available drugs. Using clearance and brain penetration studies as a screen, a series of 1,2,3, 4-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2c29021033790cffc8846029ceb1845
https://pubmed.ncbi.nlm.nih.gov/10794704
https://pubmed.ncbi.nlm.nih.gov/10794704