Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Tracey A. Laessig"'
Autor:
Daniel A. Linseman, Ron J. Bouchard, Reid A. Phelps, Thomas A Precht, Brent D. Butts, Shoshona S. Le, Maria L. Florez-McClure, Tracey A. Laessig, Kim A. Heidenreich
Publikováno v:
The Journal of Neuroscience. 24:9993-10002
Glycogen synthase kinase-3β (GSK-3β) is a critical activator of neuronal apoptosis induced by a diverse array of neurotoxic insults. However, the downstream substrates of GSK-3β that ultimately induce neuronal death are unknown. Here, we show that
Publikováno v:
Hormone and Metabolic Research. 35:763-770
Cultured rat cerebellar granule neurons (CGNs) require depolarization-mediated calcium influx for survival. Calcium regulates the activity of the pro-survival transcription factor, myocyte enhancer factor 2D (MEF2D). MEF2D is hyperphosphorylated and
Autor:
Daniel A. Linseman, Brandon J. Cornejo, Ron J. Bouchard, Tracey A. Laessig, Mary Kay Meintzer, Shoshona S. Le, Kim A. Heidenreich
Publikováno v:
Journal of Neurochemistry. 85:1488-1499
Depolarization promotes the survival of cerebellar granule neurons via activation of the transcription factor myocyte enhancer factor 2D (MEF2D). Removal of depolarization induces hyperphosphorylation of MEF2D on serine/threonine residues, resulting
Autor:
Mingtao Li, Xiaomin Wang, Kim A. Heidenreich, Morris J. Birnbaum, Tracey A. Laessig, Mary Kay Meintzer
Publikováno v:
Molecular and Cellular Biology. 20:9356-9363
Agents that elevate intracellular cyclic AMP (cAMP) levels promote neuronal survival in a manner independent of neurotrophic factors. Inhibitors of phosphatidylinositol 3 kinase and dominant-inactive mutants of the protein kinase Akt do not block the
Autor:
Andreas J. Bäumler, Yisheng Xu, Urs A. Ochsner, Jean Christophe Giárd, Gail Campbell, Tracey A. Laessig, Shawn M D Bearson, John W. Foster, Traci L. Testerman, Ferric C. Fang, Mary Ann DeGroote
Publikováno v:
Proceedings of the National Academy of Sciences. 96:7502-7507
Periplasmic Cu, Zn-cofactored superoxide dismutase (SodC) protects Gram-negative bacteria from exogenous oxidative damage. The virulent Salmonella typhimurium strain ATCC 14028s has been found to contain two discrete periplasmic Cu, Zn-SOD enzymes th
Autor:
Kim A. Heidenreich, T A Precht, Shoshona S. Le, Ron J. Bouchard, Daniel A. Linseman, Tracey A. Laessig, Brent D. Butts, Reid A. Phelps
Publikováno v:
Cell death and differentiation. 12(3)
Cerebellar granule neurons (CGNs) require depolarization for their survival in culture. When deprived of this stimulus, CGNs die via an intrinsic apoptotic cascade involving Bim induction, Bax translocation, cytochrome c release, and caspase-9 and -3
Autor:
Daniel A. Linseman, Kim A. Heidenreich, Shoshona S. Le, Charleen T. Chu, Ron J. Bouchard, Maria L. Florez-McClure, Tracey A. Laessig, Phil A. Barker
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(19)
The cellular mechanisms underlying Purkinje neuron death in various neurodegenerative disorders of the cerebellum are poorly understood. Here we investigate anin vitromodel of cerebellar neuronal death. We report that cerebellar Purkinje neurons, dep
Autor:
Ron J. Bouchard, Tracey A. Laessig, Mingtao Li, Christopher M. Bartley, Kim A. Heidenreich, Daniel A. Linseman, Shoshona S. Le, Mary Kay Meintzer
Publikováno v:
The Journal of biological chemistry. 278(42)
Cerebellar granule neuron (CGN) survival depends on activity of the myocyte enhancer factor-2 (MEF2) transcription factors. Neuronal MEF2 activity is regulated by depolarization via a mechanism that is presently unclear. Here, we show that depolariza
Autor:
Daniel A, Linseman, Brandon J, Cornejo, Shoshona S, Le, Mary Kay, Meintzer, Tracey A, Laessig, Ron J, Bouchard, Kim A, Heidenreich
Publikováno v:
Journal of neurochemistry. 85(6)
Depolarization promotes the survival of cerebellar granule neurons via activation of the transcription factor myocyte enhancer factor 2D (MEF2D). Removal of depolarization induces hyperphosphorylation of MEF2D on serine/threonine residues, resulting
Autor:
Daniel A. Linseman, Reid A. Phelps, Ron J. Bouchard, Shoshona S. Le, Kim A. Heidenreich, Tracey A. Laessig, Maria L. McClure
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 22(21)
Cerebellar granule neurons depend on insulin-like growth factor-I (IGF-I) for their survival. However, the mechanism underlying the neuroprotective effects of IGF-I is presently unclear. Here we show that IGF-I protects granule neurons by suppressing