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of 3
pro vyhledávání: '"Tracey A. Dobbs"'
Radiation-induced complex double-strand breaks (DSBs) characterised by base lesions, abasic sites or single-strand breaks in close proximity to the break termini, are believed to be a major cause of the biological effects of ionising radiation exposu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1273f79987694449394c8c5f298e4f1
https://ora.ox.ac.uk/objects/uuid:892c1ddf-1fab-4cb7-a0e3-9e65ccef97db
https://ora.ox.ac.uk/objects/uuid:892c1ddf-1fab-4cb7-a0e3-9e65ccef97db
The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and Ku heterodimer together form the biologically critical DNA-PK complex that plays key roles in the repair of ionizing radiation-induced DNA double-strand breaks through the non-homologo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d41eee10970e342a7b587d4098d197f
https://europepmc.org/articles/PMC3045832/
https://europepmc.org/articles/PMC3045832/
Autor:
Philip Bonomi, James R. Jett, James D. Luketich, Russell F. DeVore, David H. Johnson, Tracey W. Dobbs, Lewis J. Cohen, Chandra P. Belani, David S. Ettinger
Publikováno v:
Europe PubMed Central
We examined the safety and efficacy of the docetaxel/cisplatin combination in patients with advanced, previously untreated NSCLC and evaluated changes in quality of life over time. Docetaxel was administered before cisplatin (both 75 mg/m2, 1-hour in