Výsledky vyhledávání - "Tracey A Haigh"

Akademický článek

Cytotoxic CD4+ T-cells specific for EBV capsid antigen BORF1 are maintained in long-term latently infected healthy donors.

Autor: Alexander C Dowell, Tracey A Haigh, Gordon B Ryan, James E Turner, Heather M Long, Graham S Taylor

Publikováno v: PLoS Pathogens, Vol 17, Iss 12, p e1010137 (2021)

Epstein Barr Virus (EBV) infects more than 95% of the population whereupon it establishes a latent infection of B-cells that persists for life under immune control. Primary EBV infection can cause infectious mononucleosis (IM) and long-term viral car

Externí odkaz: https://doaj.org/article/1decafd434174452966f2e502835dfe0

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Akademický článek

Epstein-Barr virus evades CD4+ T cell responses in lytic cycle through BZLF1-mediated downregulation of CD74 and the cooperation of vBcl-2.

Autor: Jianmin Zuo, Wendy A Thomas, Tracey A Haigh, Leah Fitzsimmons, Heather M Long, Andrew D Hislop, Graham S Taylor, Martin Rowe

Publikováno v: PLoS Pathogens, Vol 7, Iss 12, p e1002455 (2011)

Evasion of immune T cell responses is crucial for viruses to establish persistence in the infected host. Immune evasion mechanisms of Epstein-Barr virus (EBV) in the context of MHC-I antigen presentation have been well studied. In contrast, viral int

Externí odkaz: https://doaj.org/article/6178491b1d0b40d1affd8e3e2c1c67a4

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Akademický článek

Bioengineered small extracellular vesicles deliver multiple SARS‐CoV‐2 antigenic fragments and drive a broad immunological response

Autor: Hannah K. Jackson, Heather M. Long, Juan Carlos Yam‐Puc, Roberta Palmulli, Tracey A. Haigh, Pehuén Pereyra Gerber, Jin S. Lee, Nicholas J. Matheson, Lesley Young, John Trowsdale, Mathew Lo, Graham S. Taylor, James E. Thaventhiran, James R. Edgar

Publikováno v: Journal of Extracellular Vesicles, Vol 13, Iss 2, Pp n/a-n/a (2024)

Abstract The COVID‐19 pandemic highlighted the clear risk that zoonotic viruses pose to global health and economies. The scientific community responded by developing several efficacious vaccines which were expedited by the global need for vaccines.

Externí odkaz: https://doaj.org/article/3f1b505945774238a350dd0112b78f2d

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Akademický článek

Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4+ T cell immunity

Autor: Yuan Chen, Georgina H. Mason, D. Oliver Scourfield, Alexander Greenshields-Watson, Tracey A. Haigh, Andrew K. Sewell, Heather M. Long, Awen M. Gallimore, Pierre Rizkallah, Bruce J. MacLachlan, Andrew Godkin

Publikováno v: Cell Reports, Vol 42, Iss 8, Pp 112827- (2023)

Summary: CD4+ T cells recognize a broad range of peptide epitopes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which contribute to immune memory and limit COVID-19 disease. We demonstrate that the immunogenicity of SARS-CoV-2 pept

Externí odkaz: https://doaj.org/article/89d593fdc3ac46c694db2226da7cae58

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Mutations in SARS-CoV-2 spike protein impair epitope-specific CD4+ T cell recognition

Autor: Emily X. C. Tye, Elizabeth Jinks, Tracey A. Haigh, Baksho Kaul, Prashant Patel, Helen M. Parry, Maddy L. Newby, Max Crispin, Nayandeep Kaur, Paul Moss, Samantha J. Drennan, Graham S. Taylor, Heather M. Long

CD4+ T cells are essential for protection against viruses, including SARS-CoV-2. The sensitivity of CD4+ T cells to mutations in SARS-CoV-2 variants of concern (VOCs) is poorly understood. Here, we isolated 159 SARS-CoV-2-specific CD4+ T cell clones

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b08a4a30ed5264dbb4dcc0e3adcc2a62
https://eprints.soton.ac.uk/473563/

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Heterologous prime-boost vaccination protects against EBV antigen–expressing lymphomas

Autor: Christian Münz, Julia Rühl, Andrzej Dzionek, Graham S. Taylor, Rajiv Khanna, Joanna B. Wilson, Carmen Citterio, Christine Engelmann, Carol S. Leung, Johannes H. Dreyer, Tracey A. Haigh

Publikováno v: J Clin Invest

The Epstein-Barr virus (EBV) is one of the predominant tumor viruses in humans, but so far no therapeutic or prophylactic vaccination against this transforming pathogen is available. We demonstrated that heterologous prime-boost vaccination with the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d963533e22e431c3c1ac3ab124d3292
https://doi.org/10.1172/jci125364

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Autor: Jianmin Zuo, Naeem Khan, Graham S. Taylor, Paul Murray, Navta Masand, Eleni Syrimi, Jonathan M. Irish, Benjamin E. Willcox, Pamela Kearns, Sierra Barone, Carrie R. Willcox, Tracey A. Haigh

Systemic immunity plays an important role in cancer immune surveillance and therapy but there is little detailed knowledge about the immune status of healthy children or children with cancer. We performed a high dimensional single cell analysis of sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c51916452442f0b31680f9cefc5d28b
https://doi.org/10.1101/2020.03.09.983288

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The role of tetraspanin CD63 in antigen presentation via MHC class II

Autor: Fedor Berditchevski, Alan B. Rickinson, Sven H. Petersen, Tracey A. Haigh, Graham S. Taylor, Elena Odintsova

Publikováno v: European Journal of Immunology. 41:2556-2561

Interactions between MHC class II (MHC II)-positive APCs and CD4(+) T cells are central to adaptive immune responses. Using an Epstein-Barr virus (EBV)-transformed B lymphoblastoid cell line (LCL) as MHC II-positive APCs and CD4(+) T-cell clones spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5912ec081e717173adf51a6ec1e86c6b
https://doi.org/10.1002/eji.201141438

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