Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Tracey Yi"'
Autor:
Larry J. Jolivette, Erding Hu, Andrew Q. Viet, Lois L Wright, Edward Dul, Robert B. Kirkpatrick, Robert A. Stavenger, Haifeng Cui, Weiwei Xu, Gren Z. Wang, David Kendallc Jung, Ross Bentley, David J. Behm, Robert L. Ivy, Dimitri E. Gaitanopoulos, Christopher P. Doe, Tracey Yi, Dennis Lee, Krista B. Goodman, Sarah E. Dowdell, Sanjay S. Khandekar, Gary K Smith, Christopher P. Evans, Guosen Ye, Harvey E. Fries, Simon Semus, Clark A. Sehon
Publikováno v:
Journal of Medicinal Chemistry. 50:6-9
Rho kinase (ROCK1) mediates vascular smooth muscle contraction and is a potential target for the treatment of hypertension and related disorders. Indazole amide 3 was identified as a potent and selective ROCK1 inhibitor but possessed poor oral bioava
Autor:
Robert Lafferty, Tracey Yi, Ross G. Bentley, Dennis Lee, Sanjay S. Khandekar, Christine Webb, Joseph P. Marino, Mark James Bamford, Gary K. Smith, Erding Hu, Robert N. Willette, Zunxuan Chen, Robert B. Kirkpatrick, Eugene T. Grygielko, Robert A. Stavenger, David J. Behm, Larry J. Jolivette, Lois L. Wright, David Kendall Jung, Terry Panchal, Chris P. Doe, Edward Dul
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 320:89-98
Increased Rho kinase (ROCK) activity contributes to smooth muscle contraction and regulates blood pressure homeostasis. We hypothesized that potent and selective ROCK inhibitors with novel structural motifs would help elucidate the functional role of
Autor:
Ed Dul, Robert B. Kirkpatrick, Sanjay S. Khandekar, Gary K. Smith, Tracey Yi, Gilbert F. Scott, Susan Chen, Lois L. Wrigh, Dennis Lee, Erding Hu
Publikováno v:
Protein & Peptide Letters. 13:369-376
Rho Kinase I (ROCK I) is a serine/threonine kinase that is involved in diverse cellular signaling. To further understand the physiological role of ROCK I and to identify and develop potent and selective inhibitors of ROCK I, we have overexpressed and
Publikováno v:
Management Science. 43(10):1387-1400
In designing print ads, one of the decisions the advertiser must make is which color(s) to use as executional cues in the ad. Typically, color decisions are based on intuition and anecdotal evidence. To provide guidelines for these decisions, this re
Autor:
Da-Yuan Wang, Brett Siegfried, Kyung O. Johanson, Hong Zhang, Chad Quinn, Robert S. Ames, Jingsong Yang, Thau F. Ho, Tracey Yi, Hu Li, Glenn A. Hofmann, Josh Cottom
Publikováno v:
Journal of biomolecular screening. 16(1)
A 2-step kinase assay was developed and used in a high-throughput screen (HTS) of more than 1 million compounds in an effort to identify c-Abl tyrosine kinase activators. This assay employed a 2-step phosphorylation reaction: in the first step, purif
Autor:
Gren Z. Wang, Larry J. Jolivette, Christopher Evans, Tracey Yi, David J. Behm, Krista B. Goodman, Erding Hu, Gary K. Smith, Robert B. Kirkpatrick, Semus Simon, Sarah E. Dowdell, Lois L. Wright, Patricia A. Elkins, Andrew Q. Viet, Ross Bentley, Edward Dul, Sanjay S. Khandekar, Dennis Lee, Clark A. Sehon, Christopher P. Doe
Publikováno v:
Journal of medicinal chemistry. 51(21)
Recent studies using known Rho-associated kinase isoform 1 (ROCK1) inhibitors along with cellular and molecular biology data have revealed a pivotal role of this enzyme in many aspects of cardiovascular function. Here we report a series of ROCK1 inhi
Autor:
Joseph P. Marino, Sanjay S. Khandekar, David J. Behm, Patricia A. Elkins, Dennis Lee, Sarah E. Dowdell, Robert G. Franz, Dimitri Gaitanopoulos, Haifeng Cui, Hye-Ja Oh, Mark A. Hilfiker, Yongdong Zhao, Weiwei Xu, Erding Hu, Zunxuan X. Chen, Christopher P. Doe, Jack D. Leber, David Kendall Jung, Robert B. Kirkpatrick, Robert L. Ivy, Andrew Q. Viet, Ross Bentley, Tracey Yi, Larry J. Jolivette, Krista B. Goodman, Edward Dul, Guosen Ye, Semus Simon, Lois L. Wright, Daohua Zhang, Robert A. Stavenger, Martha S. Head, Gary K. Smith
Publikováno v:
Journal of medicinal chemistry. 50(1)
The discovery, proposed binding mode, and optimization of a novel class of Rho-kinase inhibitors are presented. Appropriate substitution on the 6-position of the azabenzimidazole core provided subnanomolar enzyme potency in vitro while dramatically i
Publikováno v:
Journal of biomolecular screening. 12(1)
Most of the kinase inhibitors that are approved for therapeutic uses or that are undergoing clinical trials are directed toward the adenosine triphosphate (ATP) binding site of protein kinases. 5'-Fluorosulfonylbenzoyl 5'-adenosine (FSBA) is an activ
Publikováno v:
Journal of biomolecular screening. 10(5)
The currently approved kinase inhibitors for therapeutic uses and a number of kinase inhibitors that are undergoing clinical trials are directed toward the adenosine triphosphate (ATP) binding site of protein kinases. The 5'-fluorosulfonylbenzoyl 5'-
Publikováno v:
SSRN Electronic Journal.
A print ad was designed where the hue, chroma (saturation), and value (lightness) of the color in the ad were manipulated in a 2 x 2 x 2 between subjects design. The results revealed that differences in chroma and value had significant effects on fee