Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice

Autor: Dalvie, Neil C., Rodriguez-Aponte, Sergio A., Hartwell, Brittany L., Tostanoski, Lisa H., Biedermann, Andrew M., Crowell, Laura E., Kaur, Kawaljit, Kumru, Ozan S., Carter, Lauren, Yu, Jingyou, Chang, Aiquan, McMahan, Katherine, Courant, Thomas, Lebas, Celia, Lemnios, Ashley A., Rodrigues, Kristen A., Silva, Murillo, Johnston, Ryan S., Naranjo, Christopher A., Tracey, Mary Kate, Brady, Joseph R., Whittaker, Charles A., Yun, Dongsoo, Brunette, Natalie, Wang, Jing Yang, Walkey, Carl, Fiala, Brooke, Kar, Swagata, Porto, Maciel, Lok, Megan, Andersen, Hanne, Lewis, Mark G., Love, Kerry R., Camp, Danielle L., Silverman, Judith Maxwell, Kleanthous, Harry, Joshi, Sangeeta B., Volkin, David B., Dubois, Patrice M., Collin, Nicolas, King, Neil P., Barouch, Dan H., Irvine, Darrell J., Love, J. Christopher

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2021 Sep . 118(38), 1-9.

Externí odkaz: https://www.jstor.org/stable/27075636

Mechanism of Thimerosal-Induced Structural Destabilization of a Recombinant Rotavirus P[4] Protein Antigen Formulated as a Multi-Dose Vaccine

Autor: Kaur, Kawaljit, Xiong, Jian, Sawant, Nishant, Agarwal, Sanjeev, Hickey, John M., Holland, David A., Mukhopadhyay, Tarit K., Brady, Joseph R., Dalvie, Neil C., Tracey, Mary Kate, Love, Kerry R., Love, J. Christopher, Weis, David D., Joshi, Sangeeta B., Volkin, David B.

Publikováno v: In Journal of Pharmaceutical Sciences March 2021 110(3):1054-1066

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Molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine candidate for rotavirus

Autor: Neil C. Dalvie, D. Lee Kristensen, John M. Hickey, Celina G. Vega, J. Christopher Love, Tarit Mukhopadhyay, Viviana Parreño, Kerry R. Love, Alexandra D. Bonnyman, Charles A. Whittaker, M. Bok, Joseph R. Brady, Laura E. Crowell, Mary Kate Tracey, Andrew M. Biedermann, David B. Volkin, Sergio A. Rodriguez-Aponte, Kawaljit Kaur, Sangeeta B. Joshi

Publikováno v: Microbial Cell Factories 20 : Article number: 94 (2021)
INTA Digital (INTA)
Instituto Nacional de Tecnología Agropecuaria
instacron:INTA
Microbial Cell Factories
Microbial Cell Factories, Vol 20, Iss 1, Pp 1-14 (2021)

Background: Vaccines comprising recombinant subunit proteins are well-suited to low-cost and high-volume production for global use. The design of manufacturing processes to produce subunit vaccines depends, however, on the inherent biophysical traits

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc4c200dcecb6d859fee1731381a517
https://microbialcellfactories.biomedcentral.com/articles/10.1186/s12934-021-01583-6