Výsledky vyhledávání - "Tracee L McMiller"

Akademický článek

Immune microenvironment of Epstein-Barr virus (EBV)-negative compared to EBV-associated gastric cancers: implications for immunotherapy

Autor: Ke Xu, Qingfeng Zhu, Suzanne L Topalian, Robert A Anders, Janis M Taube, Mark Yarchoan, Keziban Ünsal-Kaçmaz, Logan L Engle, Tracee L McMiller, Sepideh Besharati, Junghwa Lee, Feriyl Bhaijee, Alan E Berger

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 11 (2024)

Background Gastric carcinomas (GC) are aggressive malignancies, and only ~15% of patients respond to anti-programmed cell death (ligand) 1 (PD-(L)1) monotherapy. However, Epstein-Barr virus (EBV)-associated GCs (~5–10% of GCs) often harbor PD-L1 an

Externí odkaz: https://doaj.org/article/ae75b3e80d294d0a8c175faf2abac4ef

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Akademický článek

Comparing anti-tumor and anti-self immunity in a patient with melanoma receiving immune checkpoint blockade

Autor: Shuming Chen, Tracee L. McMiller, Abha Soni, Farah Succaria, John-William Sidhom, Laura C. Cappelli, Livia A. Casciola-Rosen, Isaac R. Morales, Preethi Sankaran, Alan E. Berger, Julie Stein Deutsch, Qingfeng C. Zhu, Robert A. Anders, Jody E. Hooper, Drew M. Pardoll, Evan J. Lipson, Janis M. Taube, Suzanne L. Topalian

Publikováno v: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-12 (2024)

Abstract Background Tumor regression following immune checkpoint blockade (ICB) is often associated with immune-related adverse events (irAEs), marked by inflammation in non-cancerous tissues. This study was undertaken to investigate the functional r

Externí odkaz: https://doaj.org/article/44edc95deb6444eabbd3e50a4991237d

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Akademický článek

Mechanisms regulating PD-L1 expression on tumor and immune cells

Autor: Shuming Chen, George A. Crabill, Theresa S. Pritchard, Tracee L. McMiller, Ping Wei, Drew M. Pardoll, Fan Pan, Suzanne L. Topalian

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-12 (2019)

Abstract Background The PD-1/PD-L1 checkpoint is a central mediator of immunosuppression in the tumor immune microenvironment (TME) and is primarily associated with IFN-g signaling. To characterize other factors regulating PD-L1 expression on tumor a

Externí odkaz: https://doaj.org/article/789eac2ac40b4031b939a7b4505f1a07

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Akademický článek

Th17 immune microenvironment in Epstein-Barr virus–negative Hodgkin lymphoma: implications for immunotherapy

Autor: Amy S. Duffield, Maria Libera Ascierto, Robert A. Anders, Janis M. Taube, Alan K. Meeker, Shuming Chen, Tracee L. McMiller, Neil A. Phillips, Haiying Xu, Aleksandra Ogurtsova, Alan E. Berger, Drew M. Pardoll, Suzanne L. Topalian, Richard F. Ambinder

Publikováno v: Blood Advances, Vol 1, Iss 17, Pp 1324-1334 (2017)

Abstract: Classical Hodgkin lymphoma (CHL) is a neoplasm characterized by robust inflammatory infiltrates and heightened expression of the immunosuppressive PD-1/PD-L1 pathway. Although anti-PD-1 therapy can be effective in >60% of patients with refr

Externí odkaz: https://doaj.org/article/a34c1ebc512840c184df62031f0ea438

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