Short and long-term effect of dexamethasone on the transcriptome profile of primary human trabecular meshwork cells in vitro

Autor: Kandasamy Kathirvel, Karen Lester, Ravinarayanan Haribalaganesh, Ramasamy Krishnadas, Veerappan Muthukkaruppan, Brian Lane, David A. Simpson, Kasia Goljanek-Whysall, Carl Sheridan, Devarajan Bharanidharan, Colin E. Willoughby, Srinivasan Senthilkumari

Publikováno v: Kathirvel, K, Karen, L, Haribalaganesh, R, Krishnadas, R, Muthukkaruppan, V, Lane, B, Simpson, D A, Goljanek-Whysall, K, Sheridan, C, Bharanidharan, D, Willoughby, C E & Senthilkumari, S 2022, ' Short and long-term effect of dexamethasone on the transcriptome profile of primary human trabecular meshwork cells in vitro ', Scientific Reports, vol. 12, 8299 . https://doi.org/10.1038/s41598-022-12443-7
SCIENTIFIC REPORTS

In the quest of identifying newer molecular targets for the management of glucocorticoid-induced ocular hypertension (GC-OHT) and glaucoma (GCG), several microarray studies have attempted to investigate the genome-wide transcriptome profiling of prim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb36c48b3d5c59e2061f0b5dba75946f
https://pubmed.ncbi.nlm.nih.gov/35902722

Genome-Wide RNA Sequencing of Human Trabecular Meshwork Cells Treated with TGF-β1: Relevance to Pseudoexfoliation Glaucoma

Autor: Anton W. Roodnat, Breedge Callaghan, Chelsey Doyle, Megan Henry, Katarzyna Goljanek-Whysall, David A. Simpson, Carl Sheridan, Sarah D. Atkinson, Colin E. Willoughby

Publikováno v: Biomolecules; Volume 12; Issue 11; Pages: 1693
Roodnat, A W, Callaghan, B, Doyle, C, Henry, M, Goljanek-Whysall, K, Simpson, D A, Sheridan, C, Atkinson, S D & Willoughby, C E 2022, ' Genome-wide RNA sequencing of human trabecular meshwork cells treated with TGF-β1: relevance to pseudoexfoliation glaucoma ', Biomolecules, vol. 12, no. 11, 1693 . https://doi.org/10.3390/biom12111693

Pseudoexfoliation glaucoma (XFG) is an aggressive form of secondary open angle glaucoma, characterised by the production of exfoliation material and is estimated to affect 30 million people worldwide. Activation of the TGF-β pathway by TGF-β1 has b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c828786f743e4eaaf7181c91e07b24a1
https://doi.org/10.3390/biom12111693

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