Prediction of Gene Activity in Early B Cell Development Based on an Integrative Multi-Omics Analysis

Autor: Heydarian M, Tr, Luperchio, Cutler J, Cj, Mitchell, Min-Sik Kim, Pandey A, Sollner-Webb B, Reddy K

Publikováno v: ResearcherID
Europe PubMed Central

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::67899e3e1a96d440de81f6bb774138fb
http://europepmc.org/abstract/med/25544807

Neuron-specific chromatin disruption at CpG islands and aging-related regions in Kabuki syndrome mice.

Autor: Boukas L; Department of Pediatrics, Children's National Hospital, Washington, DC 20010, USA.; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA., Luperchio TR; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA., Razi A; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA., Hansen KD; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA; khansen@jhsph.edu hbjorns1@jhmi.edu.; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21218, USA., Bjornsson HT; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA; khansen@jhsph.edu hbjorns1@jhmi.edu.; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.; Faculty of Medicine, University of Iceland, 101 Reykjavík, Iceland.; Landspitali University Hospital, 101 Reykjavík, Iceland.

Publikováno v: Genome research [Genome Res] 2024 Jun 25; Vol. 34 (5), pp. 696-710. Date of Electronic Publication: 2024 Jun 25.

Peripheral blood DNA methylation and neuroanatomical responses to HDACi treatment that rescues neurological deficits in a Kabuki syndrome mouse model.

Autor: Goodman SJ; Genetics and Genome Biology, Hospital for Sick Children, Toronto, Canada., Luperchio TR; McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, USA., Ellegood J; Mouse Imaging Centre (MICe), Hospital for Sick Children, Toronto, Canada., Chater-Diehl E; Genetics and Genome Biology, Hospital for Sick Children, Toronto, Canada., Lerch JP; Mouse Imaging Centre (MICe), Hospital for Sick Children, Toronto, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Canada.; Wellcome Centre for Integrative Neuroimaging, The University of Oxford, Oxford, UK.; Nuffield Department of Clinical Neuroscience, The University of Oxford, Oxford, UK., Bjornsson HT; McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, USA.; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, USA.; Faculty of Medicine, University of Iceland, Reykjavík, Iceland.; Landspitali University Hospital, Reykjavík, Iceland., Weksberg R; Genetics and Genome Biology, Hospital for Sick Children, Toronto, Canada. rweksb@sickkids.ca.; Division of Clinical and Metabolic Genetics, Hospital for Sick Children, Toronto, Canada. rweksb@sickkids.ca.; Department of Molecular Genetics, University of Toronto, Toronto, Canada. rweksb@sickkids.ca.; Institute of Medical Science, University of Toronto, Toronto, Canada. rweksb@sickkids.ca.; Department of Paediatrics, University of Toronto, Toronto, ON, Canada. rweksb@sickkids.ca.

Publikováno v: Clinical epigenetics [Clin Epigenetics] 2023 Oct 27; Vol. 15 (1), pp. 172. Date of Electronic Publication: 2023 Oct 27.

Senescent stroma induces nuclear deformations in cancer cells via the inhibition of RhoA/ROCK/myosin II-based cytoskeletal tension.

Autor: Aifuwa I; Johns Hopkins Physical Sciences - Oncology Center, Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA., Kim BC; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.; Division of Nano-Bioengineering, Incheon National University, Incheon 22012, South Korea., Kamat P; Johns Hopkins Physical Sciences - Oncology Center, Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA., Starich B; Johns Hopkins Physical Sciences - Oncology Center, Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA., Agrawal A; Johns Hopkins Physical Sciences - Oncology Center, Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA., Tanrioven D; Johns Hopkins Physical Sciences - Oncology Center, Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD 21218, USA., Luperchio TR; Department of Biological Chemistry, Johns Hopkins University, Baltimore, MD 21218, USA., Valencia AMJ; Johns Hopkins Physical Sciences - Oncology Center, Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA., Perestrelo T; Johns Hopkins Physical Sciences - Oncology Center, Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA., Reddy K; Department of Biological Chemistry, Johns Hopkins University, Baltimore, MD 21218, USA., Ha T; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.; Howard Hughes Medical Institute, Baltimore, MD 21205, USA., Philip JM; Johns Hopkins Physical Sciences - Oncology Center, Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Oncology, Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

Publikováno v: PNAS nexus [PNAS Nexus] 2022 Dec 06; Vol. 2 (1), pp. pgac270. Date of Electronic Publication: 2022 Dec 06 (Print Publication: 2023).

Author Correction: Deficiency of TET3 leads to a genome-wide DNA hypermethylation episignature in human whole blood.

Autor: Levy MA; Molecular Genetics Laboratory, Molecular Diagnostics Division, London Health Sciences Centre, London, ON, N6A5W9, Canada., Beck DB; National Human Genome Research Institute, Bethesda, MD, 20892, USA., Metcalfe K; Division of Evolution, Infection and Genomics, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK.; Manchester Centre for Genomic Medicine, St Mary's Hospital, Health Innovation Manchester, Manchester University NHS Foundation Trust, Manchester, M13 9WL, UK., Douzgou S; Division of Evolution, Infection and Genomics, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK.; Manchester Centre for Genomic Medicine, St Mary's Hospital, Health Innovation Manchester, Manchester University NHS Foundation Trust, Manchester, M13 9WL, UK., Sithambaram S; Manchester Centre for Genomic Medicine, St Mary's Hospital, Health Innovation Manchester, Manchester University NHS Foundation Trust, Manchester, M13 9WL, UK., Cottrell T; Manchester Centre for Genomic Medicine, St Mary's Hospital, Health Innovation Manchester, Manchester University NHS Foundation Trust, Manchester, M13 9WL, UK., Ansar M; Department of Biochemistry, Faculty of Biological Sciences, Quaid-I-Azam University, 45320, Islamabad, Pakistan., Kerkhof J; Molecular Genetics Laboratory, Molecular Diagnostics Division, London Health Sciences Centre, London, ON, N6A5W9, Canada., Mignot C; Assistance Publique-Hopitaux de Paris, Sorbonne Université, Departement de Génétique, Groupe Hospitalier Pitie-Salpetriere et Hopital Trousseau, Paris, 75651, France., Nougues MC; Department of Neuropediatrics, Armand Trousseau Hospital, Assistance Publique-Hopitaux de Paris, Paris, 75012, France., Keren B; Laboratoire de génétique, Hôpital Pïtié-Salpêtrière, Assistance Publique-Hopitaux de Paris, Paris, 75013, France., Moore HW; Greenwood Genetic Center, Greenwood, SC, 29646, USA., Oegema R; Department of Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Giltay JC; Department of Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Simon M; Department of Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., van Jaarsveld RH; Department of Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Bos J; Section Clinical Genetics, Department Human Genetics, Amsterdam University Medical Centers, Amsterdam, The Netherlands., van Haelst M; Section Clinical Genetics, Department Human Genetics, Amsterdam University Medical Centers, Amsterdam, The Netherlands., Motazacker MM; Department of Human Genetics, Laboratory of Genome Diagnostics, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, Netherlands., Boon EMJ; Department of Human Genetics, VU University Medical Center Amsterdam, Amsterdam UMC, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands., Santen GWE; Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands., Ruivenkamp CAL; Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands., Alders M; Department of Human Genetics, Amsterdam Reproduction & Development Research Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands., Luperchio TR; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Boukas L; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Biostatistics, Johns Hopkins University, Baltimore, MD, 21205, USA., Ramsey K; Center for Rare Childhood Disorders, Translational Genomics Research Institute, Phoenix, AZ, USA., Narayanan V; Center for Rare Childhood Disorders, Translational Genomics Research Institute, Phoenix, AZ, USA., Schaefer GB; University of Arkansas for Medical Sciences, Springdale, AR, 72762, USA., Bonasio R; Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.; Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA., Doheny KF; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Center for Inherited Disease Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Stevenson RE; Greenwood Genetic Center, Greenwood, SC, 29646, USA., Banka S; Division of Evolution, Infection and Genomics, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK.; Manchester Centre for Genomic Medicine, St Mary's Hospital, Health Innovation Manchester, Manchester University NHS Foundation Trust, Manchester, M13 9WL, UK., Sadikovic B; Molecular Genetics Laboratory, Molecular Diagnostics Division, London Health Sciences Centre, London, ON, N6A5W9, Canada. Bekim.Sadikovic@lhsc.on.ca.; Department of Pathology and Laboratory Medicine, Western University, London, ON, N6A5W9, Canada. Bekim.Sadikovic@lhsc.on.ca., Fahrner JA; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. jfahrne1@jhmi.edu.; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. jfahrne1@jhmi.edu.

Publikováno v: NPJ genomic medicine [NPJ Genom Med] 2021 Nov 24; Vol. 6 (1), pp. 100. Date of Electronic Publication: 2021 Nov 24.