Zobrazeno 1 - 10
of 363
pro vyhledávání: '"Tozo Fujii"'
Publikováno v:
Tetrahedron. 55:4999-5016
A detailed account is given of the chiral synthesis of tri-O-methylimbricatine (3), the tri-O-methyl derivative of the structurally unique benzyltetrahydroisoquinoline alkaloid imbricatine (2) isolated from the starfish Dermasterias imbricata. The ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a00db6eae735dcc05c9b16aa0024436b
https://doi.org/10.1016/s0040-4020(99)00199-4
https://doi.org/10.1016/s0040-4020(99)00199-4
Synthetic studies on the starfish alkaloid imbricatine. Construction of an ent-imbricatine framework
Publikováno v:
Chemical & pharmaceutical bulletin. 47(1):83-89
A chiral synthetic route to the amino esters 5 and 6, which contain the fundamental framework of ent-imbricatine (ent-3), has been developed as a prelude to the total synthesis of the starfish alkaloid imbricatine (3). The route started from the sulf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84ac3ef9d6488c1e571f040e4df418f4
http://hdl.handle.net/2297/7600
http://hdl.handle.net/2297/7600
Autor:
Tozo Fujii, Masashi Ohba
Publikováno v:
Heterocycles. 47(1):525-539
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed6886e77e8e7424746b175cc5744f6
http://hdl.handle.net/2297/3274
http://hdl.handle.net/2297/3274
Publikováno v:
Chemical and Pharmaceutical Bulletin. 45:1582-1588
3-Alkyl-8-hydroxyadenines (5) have been shown to undergo regioselective methylation at the 7- or 9-position depending on the reaction conditions. Thus, treatment of 5a, c with dimetyl sulfate in aqueous NaOH provided 3-alkyl-7-methyl-8-oxoadenines (6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1951a577b513edef9535502064897984
https://doi.org/10.1248/cpb.45.1582
https://doi.org/10.1248/cpb.45.1582
Publikováno v:
Chemical and Pharmaceutical Bulletin. 45:832-841
On treatment with boiling H2O for 5-6h, 1-alkoxy-7-alkyladenines (13) underwent hydrolytic cleavage at the N(1)-C(2) and the N(1)-C(6) bonds to produce the imidazole-5-carboxamidines (14) in 53-60% yields and the imidazole-5-carboxamides (18) in 5-7%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94820c16a439e3aa80cbf6d136583906
https://doi.org/10.1248/cpb.45.832
https://doi.org/10.1248/cpb.45.832
Autor:
Yasutaka Takada, Taisuke Itaya, Tozo Fujii, Shigeji Mori, Toshiko Nishikawa, Yoshitaka Hozumi, Tohru Saito, Tae Kanai, Mayumi Shimada
Publikováno v:
Chemical and Pharmaceutical Bulletin. 45:1601-1607
An alternative synthesis of 3, 9-dimethyl-8-oxoadenine (N6-demethylcaissarone) hydrochloride (5a·HCl) starting from 9-methyl-8-oxoadenine (17) is described. The synthesis proceeded through N(7)-benzylation, N(1)-oxidation, and O-benzylation to affor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2e6ae4eeb931b5bee243adc6827468d
https://doi.org/10.1248/cpb.45.1601
https://doi.org/10.1248/cpb.45.1601
Publikováno v:
Chemical & pharmaceutical bulletin. 44(3):525-529
Synthesis of (±)-(4aα, 6α, 7α, 7aα)-hexahydro-6-hydroxy-7-methylcyclopenta[c]pyran-3(1H)-one [(±)-1] has been achieved through an 8-step route starting from 6, 7-dihydrocyclopenta-1, 3-dioxin-5(4H)-one (4). The identities of synthetic (±)-1 wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47a2813749ebfa833549de981a723768
http://hdl.handle.net/2297/7601
http://hdl.handle.net/2297/7601
Publikováno v:
Journal of the American Chemical Society. 118:8250-8257
A full account is given of the first racemic syntheses of agelasimine-A (1a) and agelasimine-B (2a), adenine-related bicyclic diterpenoids isolated from the marine sponge Agelas mauritiana. Central synthetic features include a highly stereoselective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f40ee2321382c981a6d8934bbf3c840
https://doi.org/10.1021/ja960879b
https://doi.org/10.1021/ja960879b
Autor:
Tozo Fujii
Publikováno v:
YAKUGAKU ZASSHI. 116:335-354
Nineteen benzo[a]quinolizidine alkaloids (1-19) isolated so far from Alangium plants can be classified into four types (I-IV) according to their chemical structures. Studies on racemic and chiral syntheses of these I-IV-type alkaloids are reviewed wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e2425e79c57f14c5d192201b86df0b7
https://doi.org/10.1248/yakushi1947.116.5_335
https://doi.org/10.1248/yakushi1947.116.5_335
Publikováno v:
Chemical and Pharmaceutical Bulletin. 44:594-598
7-Methyladenine (6a) and 7-ethyladenine (6b) afforded the N(1)-oxides 7a, b in 78% yield each on treatment with m-chloroperoxybenzoic acid at room temperature; this is analogous to the previously reported N-oxidation of 7-benzyladenine (6c) to give t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::069f7e43a3d82ffdff5406d8b23c6f86
https://doi.org/10.1248/cpb.44.594
https://doi.org/10.1248/cpb.44.594