Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Tozer, G.M."'
Autor:
Reynolds, S., Kazan, S.M., Anton, A., Alizadeh, T., Gunn, R.N., Paley, M.N., Tozer, G.M., Cunningham, V.J.
Dissolution dynamic nuclear polarisation (dDNP) of 13C-labelled pyruvate in magnetic resonance spectroscopy/imaging (MRS/MRSI) has the potential for monitoring tumour progression and treatment response. Pyruvate delivery, its metabolism to lactate an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::e65c1e8ca984e9eacea72ef98f50c003
https://eprints.whiterose.ac.uk/181205/1/nbm.4650.pdf
https://eprints.whiterose.ac.uk/181205/1/nbm.4650.pdf
Autor:
Holmes, T., Brown, A.W., Suggitt, M., Shaw, L.A., Simpson, L., Harrity, J.P.A., Tozer, G.M., Kanthou, C.
Combretastatin A-4 phosphate (CA4P) is a microtubule-disrupting tumour-selective vascular disrupting agent (VDA). CA4P activates the actin-regulating RhoA-GTPase/ ROCK pathway, which is required for full vascular disruption. While hypoxia renders tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::db6c4876378487ee1807e0bf488b8e83
https://eprints.whiterose.ac.uk/162676/1/s41598-020-66568-8.pdf
https://eprints.whiterose.ac.uk/162676/1/s41598-020-66568-8.pdf
Subcutaneously implanted experimental tumors in mice are commonly used in\ud cancer research. Despite their superficial location, they remain a challenge to image noninvasively\ud at sufficient spatial resolution for microvascular studies. Here we ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::7edccf0fa89bc320f196108164c628d4
Autor:
English, W.R., Lunt, S.J., Fisher, M., Lefley, D.V., Dhingra, M., Lee, Y-C., Bingham, K., Hurrell, J.E., Lyons, S.K., Kanthou, C., Tozer, G.M.
Elevated plasma concentrations of soluble VEGFA isoforms are associated with poor prognosis in parallel with improved response to treatment with the anti-VEGFA antibody bevacizumab. To uncover the underlying mechanism to these observations, we admini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::ed128186a8c643142049a645d4625217
Autor:
Reynolds, S., Metcalf, S., Cochrane, E.J., Collins, R.C., Jones, S., Paley, M.N.J., Tozer, G.M.
Purpose: A rat model was developed to enable direct administration of hyperpolarized 13C-labeled molecules into a tumorsupplying artery for magnetic resonance spectroscopy (MRS) studies of tumor metabolism. Methods: Rat P22 sarcomas were implanted in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::1d426624d862018b7d3a1c0d6eac6e1c
https://eprints.whiterose.ac.uk/112494/1/Reynolds_et_al-2017-Magnetic_Resonance_in_Medicine.pdf
https://eprints.whiterose.ac.uk/112494/1/Reynolds_et_al-2017-Magnetic_Resonance_in_Medicine.pdf
Autor:
Dall’Ara, E., Boudiffa, M., Taylor, C., Schug, D., Fiegle, E., Kennerley, A.J., Damianou, C., Tozer, G.M., Kiessling, F., Müller, R.
Publikováno v:
Mechanisms of ageing and development 160, 93-116 (2016). doi:10.1016/j.mad.2016.08.001
Mechanisms of Ageing and Development, 160
Mechanisms of Ageing and Development, 160
Several non-invasive imaging techniques are used to investigate the effect of pathologies and treatments over time in mouse models. Each preclinical in vivo technique provides longitudinal and quantitative measurements of changes in tissues and organ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::81b9cdab18a42fc1e83b9567606f74bf
https://eprints.whiterose.ac.uk/133783/1/1_s2.0_S0047637416301324_main.pdf
https://eprints.whiterose.ac.uk/133783/1/1_s2.0_S0047637416301324_main.pdf
The combretastatins are an important class of tubulin-binding agents. Of this family, a number of compounds are potent tumor Vascular Disrupting Agents (VDAs) and have shown promise in the clinic for cancer therapy. We have developed a modular synthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::07fa5e0ff8b71cba2c587bc6f613ba55
The rate of blood flow through a tissue (F) is a critical parameter for assessing the functional efficiency of a blood vessel network following angiogenesis. This chapter aims to provide the principles behind the estimation of F, how F relates to oth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::3b95fcea6f10bbfe73e548f65ccf1e7c
An efficient synthesis of [3-13C]-2,3-dihydroxy-4-methoxybenzaldehyde, an isotopically labelled probe of a common intermediate used in the synthesis of a number of biologically relevant molecules, has been achieved in 9 steps from an acyclic, non-aro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::bbd9bcb754341d926065ad7245f2ef88
Autor:
Bluff, J.E., Reynolds, S., Metcalf, S., Alizadeh, T., Kazan, S.M., Bucur, A., Wholey, E.G., Bibby, B.A.S., Williams, L., Paley, M.N., Tozer, G.M.
Purpose: To estimate the rate constant for pyruvate to lactate conversion in tumours in response to a hypoxic challenge, using hyperpolarised 13C1-pyruvate and magnetic resonance spectroscopy.\ud Methods and materials: Hypoxic inspired gas was used t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::d76653ffdb7de22cbb6148f18803562f