Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Toyotaka Yada"'
Autor:
Renan Sukmawan, Toyotaka Yada, Eiji Toyota, Yoji Neishi, Teruyoshi Kume, Yoshiro Shinozaki, Hidezo Mori, Yasuo Ogasawara, Fumihiko Kajiya, Kiyoshi Yoshida
Publikováno v:
Journal of Pharmacological Sciences, Vol 104, Iss 4, Pp 341-348 (2007)
We examined whether edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a free radical scavenger, exerts its protective effect on coronary microvessels after ischemia/reperfusion (I/R) in vivo. Ninety-minute coronary occlusion followed by reperfusion wa
Externí odkaz:
https://doaj.org/article/85d101eb51e84dce977b4a776895af35
Publikováno v:
Microcirculation (New York, N.Y. : 1994). 25(5)
OBJECTIVES It has been previously demonstrated that endothelial caveolin-1 plays crucial roles to produce an endothelium-derived hyperpolarizing factor in mouse mesenteric arteries. We examined whether this mechanism is involved in the endothelium-de
Autor:
Toyotaka Yada
Publikováno v:
Folia Pharmacologica Japonica. 143:222-225
Autor:
Keith M. Channon, Minoru Satoh, Naoki Kashihara, Kengo Kidokoro, Tamaki Sasaki, Toyotaka Yada
Publikováno v:
Europe PubMed Central
In diabetes, endothelial nitric oxide synthase (eNOS) produces superoxide anion rather than nitric oxide, referred to as "eNOS uncoupling," which may contribute to endothelial dysfunction, albuminuria, and diabetic nephropathy. Reduced levels of endo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913a05b4ebeea5c03b1a8a9dbb5e7949
https://doi.org/10.1681/asn.2012080783
https://doi.org/10.1681/asn.2012080783
Autor:
Toyotaka Yada, Hiroto Yamagishi, Keiko Morikawa, Nobuyuki Yanagihara, Aya Takaki, Junko Ohashi, Hiroaki Shimokawa, Masato Tsutsui, Yoshinori Murayama, Ender Tekes
Publikováno v:
The Journal of Experimental Medicine
The endothelium plays an important role in maintaining vascular homeostasis by synthesizing and releasing several relaxing factors, such as prostacyclin, nitric oxide (NO), and endothelium-derived hyperpolarizing factor (EDHF). We have previously dem
Autor:
Yasuo Ogasawara, Osamu Hiramatsu, Toyotaka Yada, Masahito Kajiya, Fumihiko Kajiya, Yousuke Inai
Publikováno v:
Medical & Biological Engineering & Computing. 46:411-419
The phase opposition of velocity waveforms between coronary arteries (predominantly diastolic) and veins (systolic) is the most prominent characteristic of coronary hemodynamics. This unique arterial and venous flow patterns indicate the importance o
Publikováno v:
Journal of Andrology. 29:153-163
Experimental cryptorchidism has been shown to induce germ cell apoptosis. Nitric oxide (NO), a ubiquitous free radical produced by NO synthases (NOSs), has been associated with apoptosis in a number of cell types. However, the regulation of NOSs in e
Autor:
Masami Goto, Toshio Hayashi, Masakazu Shinohara, Seinosuke Kawashima, Nobutaka Inoue, Naoto Sasaki, Toyotaka Yada, Keith M. Channon, Nicholas J. Alp, Tomofumi Takaya, Mitsuhiro Yokoyama, Ken-ichi Hirata, Akiko Fukatsu, Tomoya Yamashita
Publikováno v:
Europe PubMed Central
Objective— When the availability of tetrahydrobiopterin (BH4) is deficient, endothelial nitric oxide synthase (eNOS) produces superoxide rather than NO (uncoupled eNOS). We have shown that the atherosclerotic lesion size was augmented in apolipopro
Autor:
Kousuke Endo, Keiji Naruse, Tatsuo Iwasaki, Satoshi Mohri, Masanori Hirota, Toyotaka Yada, Juichiro Shimizu, Taro Morimoto, Yousuke Inai, Fumihiko Kajiya, Yasuo Ogasawara, Masahito Kajiya, Takahiko Kiyooka, Tohru Ohe
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 292:H2737-H2744
Pulmonary hypertension (PH) causes right ventricular (RV) hypertrophy and, according to the extent of pressure overload, eventual heart failure. We tested the hypothesis that the mechanical stress in PH-RV impairs the vasoreactivity of the RV coronar
Autor:
Hidezo Mori, Yoshitaka Morita, Yasuo Ogasawara, Yoshiro Shinozaki, Hiroaki Shimokawa, Toyotaka Yada, Yoshisuke Haruna, Masami Goto, Naoki Kashihara, Fumihiko Kajiya, Osamu Hiramatsu
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 291:H1138-H1146
We have recently demonstrated that endogenous H2O2 plays an important role in coronary autoregulation in vivo. However, the role of H2O2 during coronary ischemia-reperfusion (I/R) injury remains to be examined. In this study, we examined whether endo