Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Toyotaka Nishio"'
Autor:
Toyotaka Nishio, Jin Tokunaga, Keiichi Kawai, Norito Takamura, Tetsuya Ikeda, Kazuhiro Tanda, Kenji Ogata, Tetsuo Yamasaki, Nao Setoguchi
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 41:179-186
Flurbiprofen axetil (FPA) is an injection product and a prodrug of a non-steroidal anti-inflammatory drug (NSAID). After injection, it is rapidly hydrolyzed to the active form, flurbiprofen (FP). Since frequent injections of FPA can lead to abnormal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea5a68d023ca217ccd3c651b47956282
https://doi.org/10.1007/s13318-014-0248-z
https://doi.org/10.1007/s13318-014-0248-z
Autor:
Jin, TOKUNAGA, Yasuko, MATSUO, Norito, TAKAMURA, Ryusei, SUGIMOTO, Ai, OKAZAKI, Kazumasa, NAGAI, Tsutae, AOKI, Kenji, OGATA, Nao, SETOGUCHI, Hiroki, YOSHIDA, Masashi, NAGATA, Shuichi, KISHIMOTO, Shoji, FUKUSHIMA, Osamu, IKEDA, Toyotaka, NISHIO, Keiichi, KAWAI, Kazuhiko, ARIMORI
Publikováno v:
九州保健福祉大学研究紀要 = Journal of Kyushu University of Health and Welfare. 15:91-97
Cisplatin の蛋白結合には共有結合が関与しており、L-cysteine はcisplatin の共有結合を低下させる。そこで、この蛋白結合阻害を利用してcisplatin の肝動注療法の応用性について検討を行った
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::e4e82cf833240f788ae9d8725f6a47e9
http://id.nii.ac.jp/1147/00000933/
http://id.nii.ac.jp/1147/00000933/
Autor:
Ken-ichi Fujita, Norito Takamura, Keiichi Kawai, Toyotaka Nishio, Kazuhiko Arimori, Etsuo Chosa, Jin Tokunaga, Nao Setoguchi, Kenji Ogata, Ryuichi Yamamoto
Publikováno v:
Biopharmaceutics & Drug Disposition. 34:125-136
Diclofenac suppository, a non-steroidal anti-inflammatory drug (NSAID), is used widely in rheumatoid arthritis (RA) patients with severe arthritic pain. As the binding percentage of diclofenac to serum proteins is high, its free (unbound) concentrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7da7b716d0c3eca4357ff0fbab2086c
https://doi.org/10.1002/bdd.1829
https://doi.org/10.1002/bdd.1829
Autor:
Jin, TOKUNAGA, Norito, TAKAMURA, Kenji, OGATA, Hiroki, YOSHIDA, Nao, SETOGUCHI, Teruyoshi, KONDO, Toyotaka, NISHIO, Keiichi, KAWAI
Publikováno v:
九州保健福祉大学研究紀要 = Journal of Kyushu University of Health and Welfare. 11:153-158
非ステロイド性抗炎症薬(NSAID)フルルビプロフェン(FP)の蛋白結合率は約99%であり、組織移行性が低い。6-メトキシ-2-ナフチル酢酸(6MNA)は、NSAIDの1つであるナブメトンの活性代謝産物である
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::f2ba4cb15d2602742a7a91ceabfae03c
http://id.nii.ac.jp/1147/00000745/
http://id.nii.ac.jp/1147/00000745/
Basic examination of the cell membrane permeability of site probe agents using a cell membrane plate
Autor:
Jin, TOKUNAGA, Norito, TAKAMURA, Kenji, OGATA, Hiroki, YOSHIDA, Masashi, NAGATA, Teruyoshi, KONDO, Toyotaka, NISHIO, Keiichi, KAWAI
Publikováno v:
九州保健福祉大学研究紀要 = Journal of Kyushu University of Health and Welfare. 10:193-199
Drug efficacy depends on the amount of a preparation reaching the target tissue (grade of tissue transfer). In this experiment, we established the normal albumin concentration of a healthy adult (600 μ M) or a low-albumin state indicating marked liv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::e69032163e24b7f3bc87445bc9eab58b
http://id.nii.ac.jp/1147/00000907/
http://id.nii.ac.jp/1147/00000907/
Autor:
Norito, TAKAMURA, Jin, TOKUNAGA, Kenji, OGATA, Yumiko, FURUYA, Toshiro, MOTOYA, Toshikazu, MATSUOKA, Masami, HIRAI, Toyotaka, NISHIO, Keiichi, KAWAI, Kazuhiko, ARIMORI
Publikováno v:
九州保健福祉大学研究紀要 = Journal of Kyushu University of Health and Welfare. 7:211-215
The interaction of uremic toxins, indoxyl sulfate (IS), indoleacetic acid (IA) 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), with human serum albumin (HSA) was investigated by ultrafiltration and spectroscopic methods including ultra viol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::a0842d11d6e68a02a93b7978453982e4
http://id.nii.ac.jp/1147/00000645/
http://id.nii.ac.jp/1147/00000645/
Autor:
Hiromitsu Takahashi, Okamoto Kazuo, Naoomi Miyata, Akihiro Ohta, Masayuki Fujitake, Toyotaka Nishio, Takahiro Suzuki, Yutaka Aoyagi, Etsuo Uchino, Suwabe Yasushi, Kenji Yamada, Hiroyuki Hirono
Publikováno v:
Biological and Pharmaceutical Bulletin. 20:1076-1081
This report describes the anti-platelet aggregation activity of 48 pyrazines. Among alkyl- and arylpyrazines tested, 2,3-diphenylpyrazines showed the strongest anti-platelet aggregation activity. Then, various substituents were introduced into the ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d801b946376b7a56b2b940b494ec2ca2
https://doi.org/10.1248/bpb.20.1076
https://doi.org/10.1248/bpb.20.1076
Autor:
Nao, Setoguchi, Norito, Takamura, Ken-ichi, Fujita, Kenji, Ogata, Jin, Tokunaga, Toyotaka, Nishio, Etsuo, Chosa, Kazuhiko, Arimori, Keiichi, Kawai, Ryuichi, Yamamoto
Publikováno v:
Biopharmaceuticsdrug disposition. 34(2)
Diclofenac suppository, a non-steroidal anti-inflammatory drug (NSAID), is used widely in rheumatoid arthritis (RA) patients with severe arthritic pain. As the binding percentage of diclofenac to serum proteins is high, its free (unbound) concentrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0ace2c9337ef6c6c9b86462c41142597
https://pubmed.ncbi.nlm.nih.gov/23225308
https://pubmed.ncbi.nlm.nih.gov/23225308
Autor:
Mitsuyoshi Yoshimoto, Keiichi Kawai, Jin Tokunaga, Toyotaka Nishio, Norito Takamura, Ryuuichi Nishii
Publikováno v:
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 23(7)
Background We have studied the possibility that low-dose treatment utilizing the inhibition that may occur between two drugs at the same site of human serum albumin (HSA) improves the pharmacological effects. The purpose is to elucidate the differenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f85067254e7afa16018d050251fc8979
https://pubmed.ncbi.nlm.nih.gov/18390890
https://pubmed.ncbi.nlm.nih.gov/18390890
Autor:
Toyotaka Nishio, Norito Takamura, Ryuuichi Nishii, Jin Tokunaga, Mitsuyoshi Yoshimoto, Keiichi Kawai
Publikováno v:
Nephrology Dialysis Transplantation; Jul2008, Vol. 23 Issue 7, p2304-2304, 1p