Zobrazeno 1 - 10 of 31 pro vyhledávání: '"Toyokazu Hiranuma"'
1
Enzymatic degradation of helodermin and vasoactive intestinal polypeptide
Autor: Tamie Iizuka, Mitsugu Hachisu, Toyokazu Hiranuma, Sumie Tani
Publikováno v: Journal of Pharmacobio-Dynamics. 14:126-131
Helodermin (HDM) belongs to the vasoactive intestinal polypeptide (VIP) family of polypeptides. Degradation of HDM in the tracheal tissue isolated from a guinea-pig and by an isolated enkephalinase was studied and compared with the degradation of VIP
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b5862f687357182add1ee220790404d
https://doi.org/10.1248/bpb1978.14.126
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4
Critical role of the automodification of poly(ADP-ribose) polymerase-1 in nuclear factor-kappaB-dependent gene expression in primary cultured mouse glial cells
Autor: Hiroshi Nagaso, Hidemitsu Nakajima, Shigeru Hoshiko, Midori Ishikawa, Nobukazu Kakui, Toyokazu Hiranuma
Publikováno v: The Journal of biological chemistry. 279(41)
Synthesis of ADP-ribose polymers catalyzed by poly-(ADP-ribose) polymerase-1 (PARP-1) has been implicated in transcriptional regulation. Recent studies with PARP-1 null mice and PARP-1 inhibitors have also demonstrated that PARP-1 has an essential ro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc551d0fa7807a760da7e99f3b8cd368
https://pubmed.ncbi.nlm.nih.gov/15302869
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5
New tetrahydrobenzindoles as potent and selective 5-HT(7) antagonists with increased In vitro metabolic stability
Autor: Toyokazu Hiranuma, Chika Kikuchi, Masao Koyama, Hisashi Suzuki
Publikováno v: Bioorganicmedicinal chemistry letters. 13(1)
Chemical modifications of compound 1 (DR4004), a potent, selective antagonist of the 5-HT 7 receptor, were conducted with the aim of improving its metabolic stability. Halogenation of putative sites of oxidative metabolism afforded compounds 7 – 10
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc113d9debce463b678b3c4c51bac821
https://pubmed.ncbi.nlm.nih.gov/12467617
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6
Tetrahydrothienopyridylbutyl-tetrahydrobenzindoles: new selective ligands of the 5-HT(7) receptor
Autor: Masao Koyama, Chika Kikuchi, Toyokazu Hiranuma
Publikováno v: Bioorganicmedicinal chemistry letters. 12(18)
The synthesis and the affinity for the 5-HT(7) receptor and other receptors of a novel series of fused-ring tetrahydropyridine derivatives are described. Some of the compounds showed high affinity for the 5-HT(7) receptor. Tetrahydrothienopyridylbuty
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5223ec248b035c1ce3437dd54e25fd51
https://pubmed.ncbi.nlm.nih.gov/12182857
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7
Effects of three peptidase inhibitors, amastatin, captopril and phosphoramidon, on the hydrolysis of [Met5]-enkephalin-Arg6-Phe7 and other opioid peptides
Autor: Masayuki Kanai, Takao Taniguchi, Raita Tamaki, Kayoko Iwao, Toyokazu Hiranuma, Tetsuo Oka, Tomomi Kobayashi, Ken Kitamura, Kazuhito Akahori
Publikováno v: Naunyn-Schmiedeberg's archives of pharmacology. 357(3)
The contents of [Met5]-enkephalin-Arg6-Phe7 (met-enk-RF) and its six hydrolysis products: Y, YG, YGG, YGGF, YGGFM, and YGGFMR were estimated after incubating met-enk-RF with either a guinea-pig ileal or striatal membrane fraction for various times at
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be3ea0ecc28bd3bcc3bda593cd53cca3
https://pubmed.ncbi.nlm.nih.gov/9550299
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